The Kepler Smear Campaign: Light curves for 102 Very Bright Stars

We present the first data release of the Kepler Smear Campaign, using collateral 'smear' data obtained in the Kepler four-year mission to reconstruct light curves of 102 stars too bright to have been otherwise targeted. We describe the pipeline developed to extract and calibrate these light curves, and show that we attain photometric precision comparable to stars analyzed by the standard pipeline in the nominal Kepler mission. In this paper, aside from publishing the light curves of these stars, we focus on 66 red giants for which we detect solar-like oscillations, characterizing 33 of these in detail with spectroscopic chemical abundances and asteroseismic masses as benchmark stars. We also classify the whole sample, finding nearly all to be variable, with classical pulsations and binary effects. All source code, light curves, TRES spectra, and asteroseismic and stellar parameters are publicly available as a Kepler legacy sample.Comment: 35 pages, accepted ApJ

An asteroseismic age estimate of the open cluster NGC 6866 using Kepler and Gaia

Asteroseismology of solar-like oscillations in giant stars allow the derivation of their masses and radii. For members of open clusters this allows an age estimate of the cluster which should be identical to the age estimate from the colour-magnitude diagram, but independent of the uncertainties that are present for that type of analysis. Thus, a more precise and accurate age estimate can be obtained. We aim to measure asteroseismic properties of oscillating giant members of the open cluster NGC 6866 and utilise these for a cluster age estimate. Model comparisons allow constraints on the stellar physics, and here we investigate the efficiency of convective-core overshoot and effects of rotation during the main-sequence, which has a significant influence on the age for these relatively massive giants. We identify six giant members of NGC 6866 and derive asteroseismic measurements for five of them. This constrains the convective-core overshoot and enables a more precise and accurate age estimate than previously possible. Asteroseismology establishes the helium-core burning evolutionary phase for the giants, which have a mean mass of 2.8 $M_{\odot}$. Their radii are significantly smaller than predicted by current 1D stellar models unless the amount of convective-core overshoot on the main sequence is reduced to $\alpha_{ov} \leq 0.1 H_p$ in the step-overshoot description. Our measurements also suggest that rotation has affected the evolution of the stars in NGC 6866 in a way that is consistent with 3D simulations but not with current 1D stellar models. The cluster age is estimated to be 0.43 $\pm$ 0.05 Gyr, significantly younger and more precise than most previous estimates. We derive a precise cluster age while constraining convective-core overshooting and effects of rotation in the models. We uncover potential biases for automated age estimates of helium-core burning stars.Comment: Accepted on 21/08/2023 for publication in Section 7. Stellar structure and evolution of Astronomy & Astrophysics. 20 Pages, 11 Figures + appendi

Antioxidant treatment attenuates lactate production in diabetic nephropathy

The early progression of diabetic nephropathy is notoriously difficult to detect and quantify before the occurrence of substantial histological damage. Recently, hyperpolarized [1-13C]pyruvate has demonstrated increased lactate production in the kidney early after the onset of diabetes, implying increased lactate dehydrogenase activity as a consequence of increased nicotinamide adenine dinucleotide substrate availability due to upregulation of the polyol pathway, i.e., pseudohypoxia. In this study, we investigated the role of oxidative stress in mediating these metabolic alterations using state-of-the-art hyperpolarized magnetic resonance (MR) imaging. Ten-week-old female Wistar rats were randomly divided into three groups: healthy controls, untreated diabetic (streptozotocin treatment to induce insulinopenic diabetes), and diabetic, receiving chronic antioxidant treatment with TEMPOL (4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl) via the drinking water. Examinations were performed 2, 3, and 4 wk after the induction of diabetes by using a 3T Clinical MR system equipped with a dual tuned 13C/1H-volume rat coil. The rats received intravenous hyperpolarized [1-13C]pyruvate and were imaged using a slice-selective 13C-IDEAL spiral sequence. Untreated diabetic rats showed increased renal lactate production compared with that shown by the controls. However, chronic TEMPOL treatment significantly attenuated diabetes-induced lactate production. No significant effects of diabetes or TEMPOL were observed on [13C]alanine levels, indicating an intact glucose-alanine cycle, or [13C]bicarbonate, indicating normal flux through the Krebs cycle. In conclusion, this study demonstrates that diabetes-induced pseudohypoxia, as indicated by an increased lactate-to-pyruvate ratio, is significantly attenuated by antioxidant treatment. This demonstrates a pivotal role of oxidative stress in renal metabolic alterations occurring in early diabetes. </jats:p