Risk of cancer following primary total hip replacement or primary resurfacing arthroplasty of the hip : A retrospective cohort study in Scotland

Acknowledgements: We are grateful to Lee Barnsdale, Doug Clark, and Richard Dobbie for advice and assistance with data preparation before analysis, and to the three anonymous referees for their helpful comments and suggestions.Peer reviewedPublisher PD

Is the Scottish population living dangerously? Prevalence of multiple risk factors: the Scottish Health Survey 2003

<b>Background:</b> Risk factors are often considered individually, we aimed to investigate the prevalence of combinations of multiple behavioural risk factors and their association with socioeconomic determinants.<p></p> <b>Methods:</b> Multinomial logistic regression was used to model the associations between socioeconomic factors and multiple risk factors from data in the Scottish Health Survey 2003. Prevalence of five main behavioural risk factors - smoking alcohol, diet, overweight/obesity, and physical inactivity, and the odds in relation to demographic, individual and area socioeconomic factors.<p></p> <b>Results:</b> Full data were available on 6,574 subjects (80.7% of the survey sample). Nearly the whole adult population (97.5%) reported to have at least one behavioural risk factor; while 55% have three or more risk factors; and nearly 20% have four or all five risk factors. The most important determinants for having four or five multiple risk factors were low educational attainment which conferred around a 3-fold increased odds compared to high education; and residence in the most deprived communities (relative to least deprived) which had greater than 3-fold increased odds.<p></p> <b>Conclusions:</b> The prevalence of multiple behavioural risk factors was high and the prevalence of absence of all risk factors very low. These behavioural patterns were socioeconomically determined. Policy to address factors needs to be joined up and better consider underlying socioeconomic circumstances.<p></p&gt

Perceived, anticipated and experienced stigma: exploring manifestations and implications for young people's sexual and reproductive health and access to care in North-Western Tanzania

This work was conducted under the HPP, a five-year cooperative agreement supported by United States Agency for International Development [grant number AID-OAA-A-10-00067]

A Kiloparsec-Scale Binary Active Galactic Nucleus Confirmed by the Expanded Very Large Array

We report the confirmation of a kpc-scale binary active galactic nucleus (AGN) with high-resolution radio images from the Expanded Very Large Array (EVLA). SDSS J150243.1+111557 is a double-peaked [O III] AGN at z = 0.39 selected from the Sloan Digital Sky Survey. Our previous near-infrared adaptive optics imaging reveals two nuclei separated by 1.4" (7.4 kpc), and our optical integral-field spectroscopy suggests that they are a type-1--type-2 AGN pair. However, these data alone cannot rule out the single AGN scenario where the narrow emission-line region associated with the secondary is photoionized by the broad-line AGN in the primary. Our new EVLA images at 1.4, 5.0, and 8.5 GHz show two steep-spectrum compact radio sources spatially coincident with the optical nuclei. The radio power of the type-2 AGN is an order-of-magnitude in excess of star-forming galaxies with similar extinction-corrected [O II] 3727 luminosities, indicating that the radio emission is powered by accretion. Therefore, SDSS J150243.1+111557 is one of the few confirmed kpc-scale binary AGN systems. Spectral-energy-distribution modeling shows that SDSS J150243.1+111557 is a merger of two ~10^{11} M_sun galaxies. With both black hole masses around 10^8 Msun, the AGNs are accreting at ~10 times below the Eddington limit.Comment: ApJL accepted. 6 pages, 3 figures, 1 tabl

Tensor polarizability and dispersive quantum measurement of multilevel atoms

Optimally extracting information from measurements performed on a physical system requires an accurate model of the measurement interaction. Continuously probing the collective spin of an Alkali atom cloud via its interaction with an off-resonant optical probe is an important example of such a measurement where realistic modeling at the quantum level is possible using standard techniques from atomic physics. Typically, however, tutorial descriptions of this technique have neglected the multilevel structure of realistic atoms for the sake of simplification. In this paper we account for the full multilevel structure of Alkali atoms and derive the irreducible form of the polarizability Hamiltonian describing a typical dispersive quantum measurement. For a specific set of parameters, we then show that semiclassical predictions of the theory are consistent with our experimental observations of polarization scattering by a polarized cloud of laser-cooled Cesium atoms. We also derive the signal-to-noise ratio under a single measurement trial and use this to predict the rate of spin-squeezing with multilevel Alkali atoms for arbitrary detuning of the probe beam.Comment: Significant corrections to theory and data. Full quality figures and other information available from http://minty.caltech.edu/papers.ph

States for phase estimation in quantum interferometry

Ramsey interferometry allows the estimation of the phase $\phi$ of rotation of the pseudospin vector of an ensemble of two-state quantum systems. For $\phi$ small, the noise-to-signal ratio scales as the spin-squeezing parameter $\xi$, with $\xi<1$ possible for an entangled ensemble. However states with minimum $\xi$ are not optimal for single-shot measurements of an arbitrary phase. We define a phase-squeezing parameter, $\zeta$, which is an appropriate figure-of-merit for this case. We show that (unlike the states that minimize $\xi$), the states that minimize $\zeta$ can be created by evolving an unentangled state (coherent spin state) by the well-known 2-axis counter-twisting Hamiltonian. We analyse these and other states (for example the maximally entangled state, analogous to the optical "NOON" state $|\psi> = (|N,0>+|0,N>)/\sqrt{2}$) using several different properties, including $\xi$, $\zeta$, the coefficients in the pseudo angular momentum basis (in the three primary directions) and the angular Wigner function $W(\theta,\phi)$. Finally we discuss the experimental options for creating phase squeezed states and doing single-shot phase estimation.Comment: 8 pages and 5 figure

Near Infrared Adaptive Optics Imaging of QSO Host Galaxies

We report near-infrared (primarily H-band) adaptive optics (AO) imaging with the Gemini-N and Subaru Telescopes, of a representative sample of 32 nearby (z<0.3) QSOs selected from the Palomar-Green (PG) Bright Quasar Survey (BQS), in order to investigate the properties of the host galaxies. 2D modeling and visual inspection of the images shows that ~36% of the hosts are ellipticals, \~39% contain a prominent disk component, and ~25% are of undetermined type. 30% show obvious signs of disturbance. The mean M_H(host) = -24.82 (2.1L_H*), with a range -23.5 to -26.5 (~0.63 to 10 L_H*). At <L_H*, all hosts have a dominant disk component, while at >2 L_H* most are ellipticals. "Disturbed" hosts are found at all M_H(host), while "strongly disturbed" hosts appear to favor the more luminous hosts. Hosts with prominent disks have less luminous QSOs, while the most luminous QSOs are almost exclusively in ellipticals or in mergers (which presumably shortly will be ellipticals). At z<0.13, where our sample is complete at B-band, we find no clear correlation between M_B(QSO) and M_H(host). However, at z>0.15, the more luminous QSOs (M_B<-24.7), and 4/5 of the radio-loud QSOs, have the most luminous H-band hosts (>7L_H*), most of which are ellipticals. Finally, we find a strong correlation between the "infrared-excess", L_IR/L_BB, of QSOs with host type and degree of disturbance. Disturbed and strongly disturbed hosts and hosts with dominant disks have L_IR/L_BB twice that of non-disturbed and elliptical hosts, respectively. QSOs with "disturbed" and "strongly-disturbed" hosts are also found to have morphologies and mid/far-infrared colors that are similar to what is found for "warm" ultraluminous infrared galaxies, providing further evidence for a possible evolutionary connection between both classes of objects.Comment: 80 pages, accepted for publication in ApJ Supp

The efficacy and safety of adrenergic blockade post burn injury: a systematic review and meta-analysis

BACKGROUND The hypermetabolic state after severe burns is a major problem that can lead to several pathophysiologic changes and produce multiple sequelae. Adrenergic blockade has been widely used to reverse these changes and improve outcomes in burned patients but has not been rigorously evaluated. The aim of this systematic review was to investigate the efficacy and safety of the use of adrenergic blockade after burn injury

Improving Access to Psychological Therapies (IAPT) in the United Kingdom: A systematic review and meta‐analysis of 10‐years of practice‐based evidence

Objectives: Improving Access to Psychological Therapies (IAPT) is a national‐level dissemination programme for provision of evidence‐based psychological treatments for anxiety and depression in the United Kingdom. This paper sought to review and meta‐analyse practice‐based evidence arising from the programme. Design: A pre‐registered (CRD42018114796) systematic review and meta‐analysis. Methods: A random effects meta‐analysis was performed only on the practice‐based IAPT studies (i.e. excluding the clinical trials). Subgroup analyses examined the potential influence of particular methodologies, treatments, populations, and target conditions. Sensitivity analyses investigated potential sources of heterogeneity and bias. Results: The systematic review identified N = 60 studies, with N = 47 studies suitable for meta‐analysis. The primary meta‐analysis showed large pre‐post treatment effect sizes for depression (d = 0.87, 95% CI [0.78–0.96], p < .0001) and anxiety (d = 0.88, 95% CI [0.79–0.97], p < .0001), and a moderate effect on functional impairment (d = 0.55, 95% CI [0.48–0.61], p < .0001). The methodological features of studies influenced ESs (e.g., such as whether intention‐to‐treat or completer analyses were employed). Conclusions: Current evidence suggests that IAPT enables access to broadly effective evidence‐based psychological therapies for large numbers of patients. The limitations of the review and the clinical and methodological implications are discussed. Practitioner points: IAPT interventions are associated with large pre‐post treatment effect sizes in depression and anxiety measures. IAPT interventions are associated with moderate treatment effect sizes with regards to work and social adjustment. A reduction in dropout and also the prevention of post‐treatment relapse via the offer of follow‐up support are important areas for future development