43 research outputs found
Ion acceleration from laser-driven electrostatic shocks
Multi-dimensional particle-in-cell simulations are used to study the
generation of electrostatic shocks in plasma and the reflection of background
ions to produce high-quality and high-energy ion beams. Electrostatic shocks
are driven by the interaction of two plasmas with different density and/or
relative drift velocity. The energy and number of ions reflected by the shock
increase with increasing density ratio and relative drift velocity between the
two interacting plasmas. It is shown that the interaction of intense lasers
with tailored near-critical density plasmas allows for the efficient heating of
the plasma electrons and steepening of the plasma profile at the critical
density interface, leading to the generation of high-velocity shock structures
and high-energy ion beams. Our results indicate that high-quality 200 MeV
shock-accelerated ion beams required for medical applications may be obtained
with current laser systems.Comment: 33 pages, 12 figures, accepted for publication in Physics of Plasma
Laser-driven shock acceleration of monoenergetic ion beams
We show that monoenergetic ion beams can be accelerated by moderate Mach
number collisionless, electrostatic shocks propagating in a long scale-length
exponentially decaying plasma profile. Strong plasma heating and density
steepening produced by an intense laser pulse near the critical density can
launch such shocks that propagate in the extended plasma at high velocities.
The generation of a monoenergetic ion beam is possible due to the small and
constant sheath electric field associated with the slowly decreasing density
profile. The conditions for the acceleration of high-quality, energetic ion
beams are identified through theory and multidimensional particle-in-cell
simulations. The scaling of the ion energy with laser intensity shows that it
is possible to generate MeV proton beams with state-of-the-art 100
TW class laser systems.Comment: 13 pages, 4 figures, accepted for publication in Physical Review
Letter
Induction therapy with ipilimumab and nivolumab followed by consolidative chemoradiation as organ-sparing treatment in urothelial bladder cancer:study protocol of the INDIBLADE trial
Introduction: Studies that assessed the efficacy of pre-operative immune checkpoint blockade (ICB) in locally advanced urothelial cancer of the bladder showed encouraging pathological complete response rates, suggesting that a bladder-sparing approach may be a viable option in a subset of patients. Chemoradiation is an alternative for radical cystectomy with similar oncological outcomes, but is still mainly used in selected patients with organ-confined tumors or patients ineligible to undergo radical cystectomy. We propose to sequentially administer ICB and chemoradiation to patients with (locally advanced) muscle-invasive bladder cancer. Methods: The INDIBLADE trial is an investigator-initiated, single-arm, multicenter phase 2 trial. Fifty patients with cT2-4aN0-2M0 urothelial bladder cancer will be treated with ipilimumab 3 mg/kg on day 1, ipilimumab 3 mg/kg plus nivolumab 1 mg/kg on day 22, and nivolumab 3 mg/kg on day 43 followed by chemoradiation. The primary endpoint is the bladder-intact event-free survival (BI-EFS). Events include: local or distant recurrence, salvage cystectomy, death and switch to platinum-based chemotherapy. We will also evaluate the potential of multiparametric magnetic resonance imaging of the bladder to identify non-responders, and we will assess the clearance of circulating tumor DNA as a biomarker for ICB treatment response. Discussion: This is the first trial in which the efficacy of induction combination ICB followed by chemoradiation is being evaluated to provide bladder-preservation in patients with (locally advanced) urothelial bladder cancer. Clinical Trial Registration: The INDIBLADE trial was registered on clinicaltrials.gov on January 21, 2022 (NCT05200988).</p
Effect of temperature anisotropy on various modes and instabilities for a magnetized non-relativistic bi-Maxwellian plasma
Using kinetic theory for homogeneous collisionless magnetized plasmas, we
present an extended review of the plasma waves and instabilities and discuss
the anisotropic response of generalized relativistic dielectric tensor and
Onsager symmetry properties for arbitrary distribution functions. In general,
we observe that for such plasmas only those electromagnetic modes whose
magnetic field perturbations are perpendicular to the ambient magneticeld,
i.e.,B1 \perp B0, are effected by the anisotropy. However, in oblique
propagation all modes do show such anisotropic effects. Considering the
non-relativistic bi-Maxwellian distribution and studying the relevant
components of the general dielectric tensor under appropriate conditions, we
derive the dispersion relations for various modes and instabilities. We show
that only the electromagnetic R- and L- waves, those derived from them and the
O-mode are affected by thermal anisotropies, since they satisfy the required
condition B1\perpB0. By contrast, the perpendicularly propagating X-mode and
the modes derived from it (the pure transverse X-mode and Bernstein mode) show
no such effect. In general, we note that the thermal anisotropy modifies the
parallel propagating modes via the parallel acoustic effect, while it modifies
the perpendicular propagating modes via the Larmor-radius effect. In oblique
propagation for kinetic Alfven waves, the thermal anisotropy affects the
kinetic regime more than it affects the inertial regime. The generalized fast
mode exhibits two distinct acoustic effects, one in the direction parallel to
the ambient magnetic field and the other in the direction perpendicular to it.
In the fast-mode instability, the magneto-sonic wave causes suppression of the
firehose instability. We discuss all these propagation characteristics and
present graphic illustrations
Ab initio description of coupling phenomena between magnetic and structural degrees of freedom
Theoretical aspects of the Fireball scenario
Collisionless shocks are a key ingredient of the Fireball scenario. Yet, their formation
from the encounter of two collisionless plasma shells is not understood from first
principles. When the shells interpenetrate, the overlapping region turns unstable,
triggering the shock formation. As a first step towards a microscopic understanding of the
process, we analyze here in details the initial instability phase. On the one hand, 2D
relativistic PIC simulations are performed where two symmetric initially cold pair plasmas
collide. On the other hand, the instabilities at work are analyzed, as well as the field
at saturation and the seed field which gets amplified. For mildly relativistic motions and
onward, Weibel modes with ω = 0+iδ govern the linear
phase. We derive an expression for the duration of the linear phase in reasonable
agreement with the simulations