Finding home: Black queer historical scholarship in the United States Part II

This essay surveys the extant historical and historically minded scholarship about the political, social, and cultural life of African American/black LGBT/queer. Characterizing this area of inquiry as “black queer historical studies,” this essay addresses scholars’ diverse approaches to the challenge of archival research, current scholarship about the intersecting histories of blackness and queerness in the United States, and four key topical concerns: black “lesbian” histories, gender transgression, class, and community formation/politics.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149251/1/hic312533.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149251/2/hic312533_am.pd

Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation : Data From ROCKET AF

M. Kaste on työryhmän ROCKET AF Steering Comm jäsen.Background-Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. Methods and Results-In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose-adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all-cause mortality in the 14 171 participants in the intention-to-treat population. The median age was 73 years, and the mean CHADS(2) score was 3.5. Over 1.9 years of median follow-up, 1214 (8.6%) patients died. Kaplan-Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all-cause mortality was observed between the rivaroxaban and warfarin arms (P=0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33-1.70, P= 75 years (hazard ratio 1.69, 95% CI 1.51-1.90, P Conclusions-In a large population of patients anticoagulated for nonvalvular atrial fibrillation, approximate to 7 in 10 deaths were cardiovascular, whereasPeer reviewe

Tin-Free Access to the ABC Core of the Calyciphylline A Alkaloids and Unexpected Formation of a D‑Ring-Contracted Tetracyclic Core

A tin-free strategy for the successful cyclization of a variety of internal alkyne-containing <i>N</i>-chloroamine precursors to the ABC core via cyclization of a neutral aminyl radical is established. Deuterium labeling experiments confirm that the solvent is the primary source of the final H atom in the cyclization cascade. These conditions enabled a streamlined route to a β-ketoester intermediate poised for intramolecular Knoevenagel condensation to construct the seven-membered D-ring of calyciphylline A alkaloids. However, exposure to CsF in <i>t</i>-BuOH at elevated temperatures led to an unexpected decarboxylation to form a D-ring-contracted tetracyclic core