726 research outputs found
Low-energy electronic properties of clean CaRuO: elusive Landau quasiparticles
We have prepared high-quality epitaxial thin films of CaRuO with residual
resistivity ratios up to 55. Shubnikov-de Haas oscillations in the
magnetoresistance and a temperature dependence in the electrical
resistivity only below 1.5 K, whose coefficient is substantially suppressed in
large magnetic fields, establish CaRuO as a Fermi liquid (FL) with
anomalously low coherence scale. Non-Fermi liquid (NFL) dependence is
found between 2 and 25 K. The high sample quality allows access to the
intrinsic electronic properties via THz spectroscopy. For frequencies below 0.6
THz, the conductivity is Drude-like and can be modeled by FL concepts, while
for higher frequencies non-Drude behavior, inconsistent with FL predictions, is
found. This establishes CaRuO as a prime example of optical NFL behavior in
the THz range.Comment: 12 pages, 21 figures including supplemental materia
Persistent detwinning of iron pnictides by small magnetic fields
Our comprehensive study on EuFeAs reveals a dramatic reduction of
magnetic detwinning fields compared to other AFeAs (A = Ba, Sr, Ca)
iron pnictides by indirect magneto-elastic coupling of the Eu ions. We
find that only 0.1T are sufficient for persistent detwinning below the local
Eu ordering; above = 19K, higher fields are necessary.
Even after the field is switched off, a significant imbalance of twin domains
remains constant up to the structural and electronic phase transition (190K).
This persistent detwinning provides the unique possibility to study the low
temperature electronic in-plane anisotropy of iron pnictides without applying
any symmetrybreaking external force.Comment: accepted by Physical Review Letter
Human Milk Protein Production in Xenografts of Genetically Engineered Bovine Mammary Epithelial Stem Cells
BACKGROUND: In the bovine species milk production is well known to correlate with mammary tissue mass. However, most advances in optimizing milk production relied on improvements of breeding and husbandry practices. A better understanding of the cells that generate bovine mammary tissue could facilitate important advances in milk production and have global economic impact. With this possibility in mind, we show that a mammary stem cell population can be functionally identified and isolated from the bovine mammary gland. We also demonstrate that this stem cell population may be a promising target for manipulating the composition of cow's milk using gene transfer. METHODS AND FINDINGS: We show that the in vitro colony-forming cell assay for detecting normal primitive bipotent and lineage-restricted human mammary clonogenic progenitors are applicable to bovine mammary cells. Similarly, the ability of normal human mammary stem cells to regenerate functional bilayered structures in collagen gels placed under the kidney capsule of immunodeficient mice is shared by a subset of bovine mammary cells that lack aldehyde dehydrogenase activity. We also find that this activity is a distinguishing feature of luminal-restricted bovine progenitors. The regenerated structures recapitulate the organization of bovine mammary tissue, and milk could be readily detected in these structures when they were assessed by immunohistochemical analysis. Transplantation of the bovine cells transduced with a lentivirus encoding human β-CASEIN led to expression of the transgene and secretion of the product by their progeny regenerated in vivo. CONCLUSIONS: These findings point to a common developmental hierarchy shared by human and bovine mammary glands, providing strong evidence of common mechanisms regulating the maintenance and differentiation of mammary stem cells from both species. These results highlight the potential of novel engineering and transplant strategies for a variety of commercial applications including the production of modified milk components for human consumption
Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic Antidepressants
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109971/1/cptclpt20132.pd
Educating the Next Generation of Pharmacogenomics Experts: Global Educational Needs and Concepts
Personalised Therapeutic
Confinement and the analytic structure of the one body propagator in Scalar QED
We investigate the behavior of the one body propagator in SQED. The self
energy is calculated using three different methods: i) the simple bubble
summation, ii) the Dyson-Schwinger equation, and iii) the Feynman-Schwinger
represantation. The Feynman-Schwinger representation allows an {\em exact}
analytical result. It is shown that, while the exact result produces a real
mass pole for all couplings, the bubble sum and the Dyson-Schwinger approach in
rainbow approximation leads to complex mass poles beyond a certain critical
coupling. The model exhibits confinement, yet the exact solution still has one
body propagators with {\it real} mass poles.Comment: 5 pages 2 figures, accepted for publication in Phys. Rev.
Dynamical chiral symmetry breaking and confinement with an infrared-vanishing gluon propagator?
We study a model Dyson-Schwinger equation for the quark propagator closed
using an {\it Ansatz} for the gluon propagator of the form \mbox{} and two {\it Ans\"{a}tze} for the quark-gluon vertex: the
minimal Ball-Chiu and the modified form suggested by Curtis and Pennington.
Using the quark condensate as an order parameter, we find that there is a
critical value of such that the model does not support dynamical chiral
symmetry breaking for . We discuss and apply a confinement test which
suggests that, for all values of , the quark propagator in the model {\bf is
not} confining. Together these results suggest that this Ansatz for the gluon
propagator is inadequate as a model since it does not yield the expected
behaviour of QCD.Comment: 21 Pages including 4 PostScript figures uuencoded at the end of the
file. Replacement: slight changes of wording and emphasis. ADP-93-215/T133,
ANL-PHY-7599-TH-93, FSU-SCRI-93-108, REVTEX 3.
- …