Ethics and international business research:Considerations and best practices

Research integrity matters. It enables researchers to trust each other and their findings, and provides a basis for society’s trust in our research. We explore research integrity using the lens of international business (IB) research, focusing on IB research methods. We narrow the topic further by focusing on ethical issues associated with a single project by a single author. We examine the methodological challenges involved in conducting research in the complex IB environment and propose best practices for both quantitative and qualitative IB research methods. In some ways, this is a “back to basics” message; in other ways, we draw attention to the heightened complexity of the IB environment and the need to invest in rigorous methods and ethical practices in our unending pursuit of truth

AS-506 ''G'' Manned Lunar Landing Mission post-launch operational trajectory for 16 July 1969

Apollo 11 post-launch trajectory dat

Real-time simulation and control systems design by the Response Surface Methodology and designed experiments

This paper examines two cases where the fitting of a model to experimental data makes possible the solution of extremely difficult design and simulation problems. In the first (aerospace) case, designed experiments were conducted on a permanent magnet AC motor which provided the motive power for a flight surface actuator in a more electric aircraft application. The Response Surface Methodology is applied to the measured data to achieve inclusion of the component in a real-time distributed aircraft simulation. In the second (automotive) case, oscillatory acceleration responses are controlled via an electronically actuated (drive by wire) throttle. Designed experiments were conducted on the test vehicle to achieve a systematic excitation of the vehicle driveline. An approximation to the measured data is achieved by the Response Surface Methodology allowing a controller to be designed extremely rapidly

Prediction of bioconcentration factors in fish and invertebrates using machine learning

The application of machine learning has recently gained interest from ecotoxicological fields for its ability to model and predict chemical and/or biological processes, such as the prediction of bioconcentration. However, comparison of different models and the prediction of bioconcentration in invertebrates has not been previously evaluated. A comparison of 24 linear and machine learning models is presented herein for the prediction of bioconcentration in fish and important factors that influenced accumulation identified. R2 and root mean square error (RMSE) for the test data (n = 110 cases) ranged from 0.23–0.73 and 0.34–1.20, respectively. Model performance was critically assessed with neural networks and tree-based learners showing the best performance. An optimised 4-layer multi-layer perceptron (14 descriptors) was selected for further testing. The model was applied for cross-species prediction of bioconcentration in a freshwater invertebrate, Gammarus pulex. The model for G. pulex showed good performance with R2 of 0.99 and 0.93 for the verification and test data, respectively. Important molecular descriptors determined to influence bioconcentration were molecular mass (MW), octanol-water distribution coefficient (logD), topological polar surface area (TPSA) and number of nitrogen atoms (nN) among others. Modelling of hazard criteria such as PBT, showed potential to replace the need for animal testing. However, the use of machine learning models in the regulatory context has been minimal to date and is critically discussed herein. The movement away from experimental estimations of accumulation to in silico modelling would enable rapid prioritisation of contaminants that may pose a risk to environmental health and the food chain.</p

Assessing the reliability of uptake and elimination kinetics modelling approaches for estimating bioconcentration factors in the freshwater invertebrate, Gammarus pulex

This study considers whether the current standard toxicokinetic methods are an accurate and applicable assessment of xenobiotic exposure in an aquatic freshwater invertebrate. An in vivo exposure examined the uptake and elimination kinetics for eight pharmaceutical compounds in the amphipod crustacean, Gammarus pulex by measuring their concentrations in both biological material and in the exposure medium over a 96 h period. Selected pharmaceuticals included two anti-inflammatories (diclofenac and ibuprofen), two beta-blockers (propranolol and metoprolol), an anti-depressant (imipramine), an anti-histamine (ranitidine) and two beta-agonists (formoterol and terbutaline). Kinetic bioconcentration factors (BCFs) for the selected pharmaceuticals were derived from a first-order one-compartment model using either the simultaneous or sequential modelling methods. Using the simultaneous method for parameter estimation, BCF values ranged from 12 to 212. In contrast, the sequential method for parameter estimation resulted in bioconcentration factors ranging from 19 to 4533. Observed toxicokinetic plots showed statistically significant lack-of-fits and further interrogation of the models revealed a decreasing trend in the uptake rate constant over time for rantidine, diclofenac, imipramine, metoprolol, formoterol and terbutaline. Previous published toxicokinetic data for 14 organic micro-pollutants were also assessed and similar trends were identified to those observed in this study. The decreasing trend of the uptake rate constant over time highlights the need to interpret modelled data more comprehensively to ensure uncertainties associated with uptake and elimination parameters for determining bioconcentration factors are minimised

On Further Generalization of the Rigidity Theorem for Spacetimes with a Stationary Event Horizon or a Compact Cauchy Horizon

A rigidity theorem that applies to smooth electrovac spacetimes which represent either (A) an asymptotically flat stationary black hole or (B) a cosmological spacetime with a compact Cauchy horizon ruled by closed null geodesics was given in a recent work \cite{frw}. Here we enlarge the framework of the corresponding investigations by allowing the presence of other type of matter fields. In the first part the matter fields are involved merely implicitly via the assumption that the dominant energy condition is satisfied. In the second part Einstein-Klein-Gordon (EKG), Einstein-[non-Abelian] Higgs (E[nA]H), Einstein-[Maxwell]-Yang-Mills-dilaton (E[M]YMd) and Einstein-Yang-Mills-Higgs (EYMH) systems are studied. The black hole event horizon or, respectively, the compact Cauchy horizon of the considered spacetimes is assumed to be a smooth non-degenerate null hypersurface. It is proven that there exists a Killing vector field in a one-sided neighborhood of the horizon in EKG, E[nA]H, E[M]YMd and EYMH spacetimes. This Killing vector field is normal to the horizon, moreover, the associated matter fields are also shown to be invariant with respect to it. The presented results provide generalizations of the rigidity theorems of Hawking (for case A) and of Moncrief and Isenberg (for case B) and, in turn, they strengthen the validity of both the black hole rigidity scenario and the strong cosmic censor conjecture of classical general relativity.Comment: 25 pages, LaTex, a shortened version, including a new proof for lemma 5.1, the additional case of Einstein-Yang-Mills-Higgs systems is also covered, to appear in Class. Quant. Gra

Home safe home: Evaluation of a childhood home safety program

BACKGROUND: The London Health Sciences Centre Home Safety Program (HSP) provides safety devices, education, a safety video, and home safety checklist to all first-time parents for the reduction of childhood home injuries. The objective of this study was to evaluate the HSP for the prevention of home injuries in children up to 2 years of age. METHODS: A program evaluation was performed with follow-up survey, along with an interrupted time series analysis of emergency department (ED) visits for home injuries 5 years before (2007–2013) and 2 years after (2013–2015) implementation. Spatial analysis of ED visits was undertaken to assess differences in home injury rates by dissemination areas controlling differences in socioeconomic status (i.e., income, education, and lone-parent status) at the neighborhood level. RESULTS: A total of 3,458 first-time parents participated in the HSP (a 74% compliance rate). Of these, 20% (n = 696) of parents responded to our questionnaire, with 94% reporting the program to be useful (median, 6; interquartile range,2 on a 7-point Likert scale) and 81% learning new strategies for preventing home injuries. The median age of the respondent\u27s babies were 12 months (interquartile range, 1). The home safety check list was used by 87% of respondents to identify hazards in their home, with 95% taking action to minimize the risk. The time series analysis demonstrated a significant decline in ED visits for home injuries in toddlers younger than2 years of age after HSP implementation. The declines in ED visits for home injuries remained significant over and above each socioeconomic status covariate. CONCLUSION: Removing hazards, supervision, and installing safety devices are key facilitators in the reduction of home injuries. Parents found the HSP useful to identify hazards, learn new strategies, build confidence, and provide safety products. Initial finding suggests that the program is effective in reducing home injuries in children up to 2 years of ag

Information technology in support of research, scholarship, and creative activities: A strategic plan for Research Technologies – a division of UITS and a PTI Service and Cyberinfrastructure Center

Stewart, C.A., M.R. Link, E. Wernert, W.K. Barnett, T.M. Miller. 2012. Information technology in support of research, scholarship, and creative activities: A strategic plan for Research Technologies – a division of UITS and a PTI Service and Cyberinfrastructure Center. Indiana University, Bloomington, IN. PTI Technical Report PTI-TR12-007.IU is currently executing its second information technology strategic plan – Empowering People: Indiana University's Strategic Plan for Information Technology 2009 (hereafter referred to as Empowering People). In this document, we set out long-term goals for the Research Technologies (RT) division of UITS, reaffirm specific goals set for RT for 2019, describe Actions within Empowering People for which RT is responsible, and describe the new internal structure of Research Technologies. The mission of the Research Technologies division of UITS is to develop, deliver, and support advanced technology solutions that improve productivity of and enable new possibilities in research, scholarly endeavors, and creative activity at Indiana University and beyond; and to complement this with education and technology translation activities to improve the quality of life of people in Indiana, the nation, and the world