Gyroplane Derivative Identification Using a Matlab Routine. Aero Dept Int. Rep No. 9715

In the following report it is described how a routine implemented in the Matlab software package is used for identifying the stability derivatives of a gyroplane. The software is designed to apply a frequency domain least squares approach in order to estimate the longitudinal and lateral force and moment derivatives of the aircraft. The aircraft system itself is represented as a linear state space model. The time histories of the system states in conjunction with the pilot input are analysed in order to perform the identification. Initially the time series are transformed into the frequency domain. Linear regression is then performed over a suitable frequency range and an estimate of the stability derivatives together with the corresponding standard errors, is produced. The method is applied and tested against real data obtained from research conducted in the past within the department

Gyroplane Derivative Identification Using a Matlab Routine. Aero Dept Int. Rep No. 9715

In the following report it is described how a routine implemented in the Matlab software package is used for identifying the stability derivatives of a gyroplane. The software is designed to apply a frequency domain least squares approach in order to estimate the longitudinal and lateral force and moment derivatives of the aircraft. The aircraft system itself is represented as a linear state space model. The time histories of the system states in conjunction with the pilot input are analysed in order to perform the identification. Initially the time series are transformed into the frequency domain. Linear regression is then performed over a suitable frequency range and an estimate of the stability derivatives together with the corresponding standard errors, is produced. The method is applied and tested against real data obtained from research conducted in the past within the department

The Calibration and Testing of the G-BWTP Montgomerie Gyroplane Instrumentation. Aero Dept Int. Rep No. 9823

In the following report a quantitative description will be given of the calibration and testing for the instrumentation of the G-BWTP Montgomerie gyroplane. This light aircraft together with the instrumentation package has been acquired by the department in order to enhance the research in the field of rotorcraft flight dynamics. The gyroplane is due to be flight tested within the next months providing the opportunity to acquire data unique in the rotorcraft field. The intention of this report is to illustrate the way in which parameters relating to the sensor characteristics, such as the calibration constants, were derived and how the sensors themselves were tested using a well established software package. A presentation will also be given of the design of the full software program to be used for the data acquisition and analysis. The key objective of the report is to provide a reference on the way in which instrumentation is set up for the flight testing of a light gyroplane

The D153del mutation in GNB3 gene causes tissue specific signalling patterns and an abnormal renal morphology in rge chickens

Background The GNB3 gene is expressed in cone but not rod photoreceptors of vertebrates, where it acts as the β transducin subunit in the colour visual transduction process. A naturally occurring mutation ‘D153del’ in the GNB3 gene causes the recessively inherited blinding phenotype retinopathy globe enlarged (rge) disease in chickens. GNB3 is however also expressed in most other vertebrate tissues suggesting that the D153del mutation may exert pathological effects that outlie from eye. Principal Findings Recombinant studies in COS-7 cells that were transfected with normal and mutant recombinant GNB3 constructs and subjected to cycloheximide chase showed that the mutant GNB3d protein had a much shorter half life compared to normal GNB3. GNB3 codes for the Gβ3 protein subunit that, together with different Gγ and Gα subunits, activates and regulates phosphorylation cascades in different tissues. As expected, the relative levels of cGMP and cAMP secondary messengers and their activated kinases such as MAPK, AKT and GRK2 were also found to be altered significantly in a tissue specific manner in rge chickens. Histochemical analysis on kidney tissue sections, from rge homozygous affected chickens, showed the chickens had enlargement of the glomerular capsule, causing glomerulomegaly and tubulointerstitial inflammation whereas other tissues (brain, heart, liver, pancreas) were unaffected. Significance These findings confirm that the D153del mutation in GNB3 gene targets GNB3 protein to early degradation. Lack of GNB3 signalling causes reduced phosphorylation activity of ERK2 and AKT leading to severe pathological phenotypes such as blindness and renal abnormalities in rge chickens

Malignant Peripheral Nerve Sheath Tumors State of the Science: Leveraging Clinical and Biological Insights into Effective Therapies.

Malignant peripheral nerve sheath tumor (MPNST) is the leading cause of mortality in patients with neurofibromatosis type 1. In 2002, an MPNST consensus statement reviewed the current knowledge and provided guidance for the diagnosis and management of MPNST. Although the improvement in clinical outcome has not changed, substantial progress has been made in understanding the natural history and biology of MPNST through imaging and genomic advances since 2002. Genetically engineered mouse models that develop MPNST spontaneously have greatly facilitated preclinical evaluation of novel drugs for translation into clinical trials led by consortia efforts. Continued work in identifying alterations that contribute to the transformation, progression, and metastasis of MPNST coupled with longitudinal follow-up, biobanking, and data sharing is needed to develop prognostic biomarkers and effective prevention and therapeutic strategies for MPNST

Malignant Peripheral Nerve Sheath Tumors State of the Science: Leveraging Clinical and Biological Insights into Effective Therapies.

Malignant peripheral nerve sheath tumor (MPNST) is the leading cause of mortality in patients with neurofibromatosis type 1. In 2002, an MPNST consensus statement reviewed the current knowledge and provided guidance for the diagnosis and management of MPNST. Although the improvement in clinical outcome has not changed, substantial progress has been made in understanding the natural history and biology of MPNST through imaging and genomic advances since 2002. Genetically engineered mouse models that develop MPNST spontaneously have greatly facilitated preclinical evaluation of novel drugs for translation into clinical trials led by consortia efforts. Continued work in identifying alterations that contribute to the transformation, progression, and metastasis of MPNST coupled with longitudinal follow-up, biobanking, and data sharing is needed to develop prognostic biomarkers and effective prevention and therapeutic strategies for MPNST

Quantum Conductance Oscillations in Metal/Molecule/Metal Switches at Room Temperature

Conductance switching has been reported in many molecular junction devices, but in most cases has not been convincingly explained. We investigate conductance switching in Pt/stearic acid monolayer/Ti devices using pressure-modulated conductance microscopy. For devices with conductance G>>G_Q or G<<G_Q, where GQ=2e^2/h is the conductance quantum, pressure-induced conductance peaks <30 nm in diameter are observed, indicating the formation of nanoscale conducting pathways between the electrodes. For devices with G~ 1- 2 G_Q, in addition to conductance peaks we also observed conductance dips and oscillations in response to localized pressure. These results can be modeled by considering interfering electron waves along a quantum conductance channel between two partially transmitting electrode surfaces. Our findings underscore the possible use of these devices as atomic-scale switches

The Ursinus Weekly, October 9, 1950

Thespians pick Angel Street as Fall play • French Club sees slides of France • Alpha Phi Omega frat opens second year of campus activity • UN delegate from India to speak Friday at Philadelphia forum • McConnell to speak at Founders\u27 Day in Bomberger Hall • Sigma Rho formulates plans for 1950-51 terms • Y to conduct weekend retreat; Rally held Wednesday • Relax customs for frosh girls after stunt day • IRC hears speech on Chinese colleges • Four conferences held this Summer on Ursinus campus • Varsity Club to sponsor Old Timers\u27 Day dance • Czech to speak at first Forum on October 17 • Curtain Club adopts use of group system • Pre-legal society head issues call for people to join the group • WAA to sell Christmas supplies in girls\u27 dorms in near future • Editorial: Confusion or coordination?; From proposal to project • Letters to the editor • Doc Philip keeps Ursinus campus musical • Freshman is native of Spain • Stagg\u27s granddaughter enrolls in Junior class • Senior quartet wins appearance on TV; 51\u27ers celebrate triumph by singing • James Herbsleb chosen Pi Gamma Mu advisor • Millers\u27 Summer mixes work and play; Enjoy scenery and local peculiarities • New preceptress • Booters to open with Muhlenberg • Hockey team has seven returnees • Garrison\u27s arm carries Fords to 20-12 triumph • English professors to take to the stage in presentation of a series of readings • McKee plays part of invisible rabbit during Summer with Barnstormershttps://digitalcommons.ursinus.edu/weekly/1547/thumbnail.jp