1,962 research outputs found

    Current Understanding of the Impact of Childhood Obesity on the Foot and Lower Limb

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    Childhood obesity has emerged in recent years as a major public health problem. As this continues to concern across local, national and international populations, and as our understanding of obesity advances, access to multi-disciplinary care and understanding of the complications is warranted. Recent findings have suggested that the musculoskeletal system is one of the multiple body systems compromised by obesity and that aberrant biomechanical function may be a precursor to the onset of musculoskeletal symptoms. This review will consider childhood obesity and its impact on the paediatric foot and lower limb through examination of literature on foot structure and biomechanics of gait. An overview of evidence-based management is out with the context of this review, however some recommendations for clinical practice will be proposed

    Talking SMAAC: A New Tool to Measure Soil Respiration and Microbial Activity

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    Soil respiration measurements are widely used to quantify carbon fluxes and ascertain soil biological properties related to soil microbial ecology and soil health, yet current methods to measure soil respiration either require expensive equipment or use discrete spot measurements that may have limited accuracy, and neglect underlying response dynamics. To overcome these drawbacks, we developed an inexpensive setup for measuring CO2 called the soil microbial activity assessment contraption (SMAAC). We then compared the SMAAC with a commercial infrared gas analyzer (IRGA) unit by analyzing a soil that had been subjected to two different management practices: grass buffer vs. row crop cultivation with tillage. These comparisons were done using three configurations that detected (1) in situ soil respiration, (2) CO2 burst tests, and (3) substrate induced respiration (SIR), a measure of active microbial biomass. The SMAAC provided consistent readings with the commercial IRGA unit for all three configurations tested, showing that the SMAAC can perform well as an inexpensive yet accurate tool for measuring soil respiration and microbial activity

    MicroRNA Biomarkers for Infectious Diseases: From Basic Research to Biosensing

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    In the pursuit of improved diagnostic tests for infectious diseases, several classes of molecules have been scrutinized as prospective biomarkers. Small (18–22 nucleotide), non-coding RNA transcripts called microRNAs (miRNAs) have emerged as promising candidates with extensive diagnostic potential, due to their role in numerous diseases, previously established methods for quantitation and their stability within biofluids. Despite efforts to identify, characterize and apply miRNA signatures as diagnostic markers in a range of non-infectious diseases, their application in infectious disease has advanced relatively slowly. Here, we outline the benefits that miRNA biomarkers offer to the diagnosis, management, and treatment of infectious diseases. Investigation of these novel biomarkers could advance the use of personalized medicine in infectious disease treatment, which raises important considerations for validating their use as diagnostic or prognostic markers. Finally, we discuss new and emerging miRNA detection platforms, with a focus on rapid, point-of-care testing, to evaluate the benefits and obstacles of miRNA biomarkers for infectious disease

    Distribution of Metals in the Termite Tumulitermes tumuli (Froggatt): Two Types of Malpighian Tubule Concretion Host Zn and Ca Mutually Exclusively

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    The aim of this study was to determine specific distribution of metals in the termite Tumulitermes tumuli (Froggatt) and identify specific organs within the termite that host elevated metals and therefore play an important role in the regulation and transfer of these back into the environment. Like other insects, termites bio-accumulate essential metals to reinforce cuticular structures and utilize storage detoxification for other metals including Ca, P, Mg and K. Previously, Mn and Zn have been found concentrated in mandible tips and are associated with increased hardness whereas Ca, P, Mg and K are accumulated in Malpighian tubules. Using high resolution Particle Induced X-Ray Emission (PIXE) mapping of whole termites and Scanning Electron Microscope (SEM) Energy Dispersive X-ray (EDX) spot analysis, localised accumulations of metals in the termite T. tumuli were identified. Tumulitermes tumuli was found to have proportionally high Mn concentrations in mandible tips. Malpighian tubules had significant enrichment of Zn (1.6%), Mg (4.9%), P (6.8%), Ca (2.7%) and K (2.4%). Synchrotron scanning X-ray Fluorescence Microprobe (XFM) mapping demonstrated two different concretion types defined by the mutually exclusive presence of Ca and Zn. In-situ SEM EDX realisation of these concretions is problematic due to the excitation volume caused by operating conditions required to detect minor amounts of Zn in the presence of significant amounts of Na. For this reason, previous researchers have not demonstrated this surprising finding

    Mapping spacetimes with LISA: inspiral of a test-body in a `quasi-Kerr' field

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    The future LISA detector will constitute the prime instrument for high-precision gravitational wave observations.LISA is expected to provide information for the properties of spacetime in the vicinity of massive black holes which reside in galactic nuclei.Such black holes can capture stellar-mass compact objects, which afterwards slowly inspiral,radiating gravitational waves.The body's orbital motion and the associated waveform carry information about the spacetime metric of the massive black hole,and it is possible to extract this information and experimentally identify (or not!) a Kerr black hole.In this paper we lay the foundations for a practical `spacetime-mapping' framework. Our work is based on the assumption that the massive body is not necessarily a Kerr black hole, and that the vacuum exterior spacetime is stationary axisymmetric,described by a metric which deviates slightly from the Kerr metric. We first provide a simple recipe for building such a `quasi-Kerr' metric by adding to the Kerr metric the deviation in the value of the quadrupole moment. We then study geodesic motion in this metric,focusing on equatorial orbits. We proceed by computing `kludge' waveforms which we compare with their Kerr counterparts. We find that a modest deviation from the Kerr metric is sufficient for producing a significant mismatch between the waveforms, provided we fix the orbital parameters. This result suggests that an attempt to use Kerr waveform templates for studying EMRIs around a non-Kerr object might result in serious loss of signal-to-noise ratio and total number of detected events. The waveform comparisons also unveil a `confusion' problem, that is the possibility of matching a true non-Kerr waveform with a Kerr template of different orbital parameters.Comment: 19 pages, 6 figure

    Design and Implementation of a Studio-Based General Chemistry Course

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    Most students taking general chemistry courses do not intend to pursue careers in chemistry; in fact, they are more likely to end up in positions where they fund, write, or vote for chemical research and policies. Our profession continues to ask how we can teach students scientific reasoning skills and chemical understanding in general chemistry that they are able to take beyond the classroom into their everyday lives. The emerging answer at this university is the studio teaching method, which incorporates the “best teaching and learning practices†recommended by chemical education research within an integrated lecture–lab technology-intensive environment. The design, implementation, and pedagogical rationale of studio general chemistry are described
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