Heat Capacity Measurements in Pulsed Magnetic Fields

The new NHMFL 60T quasi-continuous magnet produces a flat-top field for a period of 100 ms at 60 Tesla, and for longer time at lower fields, e.g. 0.5 sec at 35 Tesla. We have developed for the first time the capability to measure heat capacity at very high magnetic fields in the NHMFL 60 T quasi-continuous magnet at LANL, using a probe built out of various plastic materials. The field plateau allows us to utilize a heat-pulse method to obtain heat capacity data. Proof-of-principle heat capacity experiments were performed on a variety of correlated electron systems. Both magnet performance characteristics and physical properties of various materials studied hold out a promise of wide application of this new tool.Comment: 6 pages, 3 figures, World Scientific Pub. Co., to be publishe

JNCC Offshore Natura Survey : Anton Dohrn Seamount and East Rockall Bank areas of search : 2009/03-JNCC Cruise Report

This cruise report summarises operations and initial observations onboard the M/V Franklin during cruise 2009/03-JNCC on behalf of the Joint Nature Conservation Committee (JNCC). The cruise took place between the 1st and 29th of July 2009 and surveyed two Areas of Search (AoS) for offshore Special Areas of Conservation (SACs): Anton Dohrn Seamount located 155km west of the St Kilda archipelago, and East Rockall Bank located 260km west of the St Kilda archipelago (Figure 1). The main aims of the survey were to acquire acoustic and photographic “ground-truthing” data to enable geological, geomorphological and biological characterisation of the Anton Dohrn Seamount and East Rockall Bank AoS. Specifically, the data acquired will lead to the production of broadscale habitat maps, the identification and description of Annex I reef habitats with particular attention to the occurrence of bedrock, stony and biogenic reef, to identify and record any anthropogenic impacts in the areas of search and finally to evaluate data acquisition methods, techniques and equipment. The work programme was highly successful with 215 line kilometres of multibeam echosounder and 10 photographic “ground-truthing” sites acquired in the Anton Dohrn Seamount AoS, and 692 line kilometres of multibeam echosounder and 168 line kilometres of sidescan sonar data and 17 photographic “ground-truthing” sites acquired in the East Rockall Bank AoS. No physical sea-bed samples were acquired during this cruise. The data revealed the flanks and area immediately adjacent to Anton Dohrn Seamount to comprise predominantly gravel-rich sediment with bedrock outcropping on the steeper sections of the Seamount flanks. East Rockall Bank comprised predominantly gravelly muddy sand on the eastern flank of the Bank with gravel- and sand-rich sediments dominating the crest of the Bank. Interestingly, the parasitic cones surveyed within the Anton Dohrn area of search comprised predominantly corals, including large gorgonian species, small bamboo coral, the soft coral Anthomastus sp. and the antipatharian Leiopathes sp. Significant bedrock reef was encountered during the course of this cruise along an escarpment located on the eastern flank of Rockall Bank roughly coincident with the 500m bathymetric contour. This laterally extensive feature primarily comprises volcanic bedrock with possible sedimentary bedrock cropping out at sea bed colonised by large stylsaterid hydrocorals and sponges. Preliminary observations and interpretation of the data acquired during the course of this cruise suggest that several sites may fit the definition of Annex I reef under the EC Habitats Directive. If they fulfil the criteria for Annex I reef, they will be assessed against site selection criteria as possible areas for consideration as SACs

Calculation of the substitutional fraction of ion-implanted He in an Fe target

Ion-implantation is a useful technique to study irradiation damage in nuclear materials. To study He effects in nuclear fusion conditions, He is co-implanted with damage ions to reproduce the correct He/dpa ratios in the desired or available depth range. However, the short-term fate of these He ions, i.e over the time scales of their own collisional phase, has not been yet unequivocally established. Here we present an atomistic study of the short-term evolution of He implantation in an Fe substrate to approximate the conditions encountered in dual ion-implantation studies in ferritic materials. Specifically, we calculate the fraction of He atoms that end up in substitutional sites shortly after implantation, i.e. before they contribute to long-term miscrostructural evolution. We find that fractions of at most 3% should be expected for most implantation studies. In addition, we carry out an exhaustive calculation of interstitial He migration energy barriers in the vicinity of matrix vacancies and find that they vary from approximately 20 to 60 meV depending on the separation and orientation of the He-vacancy pair.Comment: 7 pages, 6 figures, 2 table

Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer.

Renal cell carcinoma (RCC) is increasing in incidence, and a complete cure remains elusive. While immune-checkpoint antibodies are promising, interferon-based immunotherapy has been disappointing. Tryptophan metabolism, which produces immunosuppressive metabolites, is enhanced in RCC. Here we show indolamine-2,3-dioxygenase-1 (IDO1) expression, a kynurenine pathway enzyme, is increased not only in tumor cells but also in the microenvironment of human RCC compared to normal kidney tissues. Neither kynurenine metabolites nor IDO inhibitors affected the survival or proliferation of human RCC or murine renal cell adenocarcinoma (RENCA) cells in vitro. However, interferon-gamma (IFNγ) induced high levels of IDO1 in both RCC and RENCA cells, concomitant with enhanced kynurenine levels in conditioned media. Induction of IDO1 by IFNα was weaker than by IFNγ. Neither the IDO1 inhibitor methyl-thiohydantoin-DL-tryptophan (MTH-trp) nor IFNα alone inhibited RENCA tumor growth, however the combination of MTH-trp and IFNα reduced tumor growth compared to IFNα. Thus, the failure of IFNα therapy for human RCC is likely due to its inability to overcome the immunosuppressive environment created by increased IDO1. Based on our data, and given that IDO inhibitors are already in clinical trials for other malignancies, IFNα therapy with an IDO inhibitor should be revisited for RCC

Benthic assemblages of the Anton Dohrn seamount (NE Atlantic): defining deep-sea biotopes to support habitat mapping and management efforts with a focus on vulnerable marine ecosystems

In 2009 the NW and SE flanks of Anton Dohrn Seamount were surveyed using multibeam echosounder and video ground-truthing to characterise megabenthic biological assemblages (biotopes) and assess those which clearly adhere to the definition of Vulnerable Marine Ecosystems, for use in habitat mapping. A combination of multivariate analysis of still imagery and video ground-truthing defined 13 comprehensive descriptions of biotopes that function as mapping units in an applied context. The data reveals that the NW and SE sides of Anton Dohrn Seamount (ADS) are topographically complex and harbour diverse biological assemblages, some of which agree with current definitions of ‘listed’ habitats of conservation concern. Ten of these biotopes could easily be considered Vulnerable Marine Ecosystems; three coral gardens, four cold-water coral reefs, two xenophyophore communities and one sponge dominated community, with remaining biotopes requiring more detailed assessment. Coral gardens were only found on positive geomorphic features, namely parasitic cones and radial ridges, found both sides of the seamount over a depth of 1311–1740 m. Two cold-water coral reefs (equivalent to summit reef) were mapped on the NW side of the seamount; Lophelia pertusa reef associated with the cliff top mounds at a depth of 747–791 m and Solenosmilia variabilis reef on a radial ridge at a depth of 1318-1351 m. Xenophyophore communities were mapped from both sides of the seamount at a depth of 1099–1770 m and were either associated with geomorphic features or were in close proximity (< 100 m) to them. The sponge dominated community was found on the steep escarpment either side of the seamount over at a depth of 854-1345 m. Multivariate diversity revealed the xenophyophore biotopes to be the least diverse, and a hard substratum biotope characterised by serpulids and the sessile holothurian, Psolus squamatus, as the most diverse

Solution pans and linear sand bedforms on the bare-rock limestone shelf of the Campeche Bank, Yucatán Peninsula, Mexico

A high-resolution, near-surface geophysical survey was conducted in 2013 on the Campeche Bank, a carbonate platform offshore of Yucatán, Mexico, to provide a hazard assessment for future scientific drilling into the Chicxulub impact crater. It also provided an opportunity to obtain detailed information on the seafloor morphology and shallow stratigraphy of this understudied region. The seafloor exhibited two morphologies: (1) small-scale (<2 m) bare-rock karstic features, and (2) thin (<1 m) linear sand accumulations overlying the bedrock. Solution pans, circular to oblong depressions featured flat bottoms and steep sides, were the dominant karstic features; they are known to form subaerially by the pooling of rainwater and dissolution of carbonate. Observed pans were 10–50 cm deep and generally 1–8 m wide, but occasionally reach 15 m, significantly larger than any solution pan observed on land (maximum 6 m). These features likely grew over the course of many 10's of thousands of years in an arid environment while subaerially exposed during lowered sea levels. Surface sands are organized into linear bedforms oriented NE-SW, 10's to 100's meters wide, and kilometers long. These features are identified as sand ribbons (longitudinal bedforms), and contained asymmetric secondary transverse bedforms that indicate NE-directed flow. This orientation is incompatible with the prevalent westward current direction; we hypothesize that these features are storm-generated