Protein synthesis at synaptic sites on dendrites

Studies over the past 20 years have revealed that gene expression in neurons is carried out by a distributed network of translational machinery. One component of this network is localized in dendrites, where polyribosomes and associated membranous elements are positioned beneath synapses and translate a particular population of dendritic mRNAs. The localization of translation machinery and mRNAs at synapses endows individual synapses with the capability to independently control synaptic strength through the local synthesis of proteins. The present review discusses recent studies linking synaptic plasticity to dendritic protein synthesis and mRNA trafficking and considers how these processes are regulated. We summarize recent information about how synaptic signaling is coupled to local translation and to the delivery of newly transcribed mRNAs to activated synaptic sites and how local translation may play a role in activity-dependent synaptic modification

An Evaluation of Soil Extracellular Enzyme Activity in Response to Burning as a Forest Restoration Technique

Burning is a method of forest restoration with the goal of returning natural tree species to ecosystems. Burning has a wide range of effects on an ecosystem, including the alteration of important soil processes and characteristics. One of the key components of soil is the activity of extracellular enzymes, which can be used to provide insight into the nutritional requirements of soil microbes as well as nutrient availability and cycling. Because enzymes are important in the overall functioning of soil and can be used to assess soil health, there is great need to examine the effects of burning on soil enzyme activity. The aim of this study was to assess differences in the activity of five enzymes (phosphatase, β-glucosidase, NAGase, phenol oxidase, and peroxidase) in response to historical burning, as compared to an unburned plot. Soil samples were collected from three sites (unburned, prescribed burn, and wildfire) in an upland forest of north Mississippi and assayed for enzyme activity. NAGase and phenol oxidase activity was higher in the burned plot, while phosphatase and β-glucosidase activity was lower, and peroxidase was generally unaffected. While enzyme activity is subject to change following burning, how certain enzymes respond is yet to be determined. However, the enzymes assayed in this study proved to be sensitive to fire, suggesting that soil enzyme activity can be used as a measure of soil quality or health during the restoration process

On the locus formed by the maximum heights of projectile motion with air resistance

We present an analysis on the geometrical place formed by the set of maxima of the trajectories of a projectile launched in a media with linear drag. Such a place, the locus of apexes, is written in term of the Lambert $W$ function in polar coordinates, confirming the special role played by this function in the problem. In order to characterize the locus, a study of its curvature is presented in two parameterizations, in terms of the launch angle and in the polar one. The angles of maximum curvature are compared with other important angles in the projectile problem. As an addendum, we find that the synchronous curve in this problem is a circle as in the drag-free case.Comment: 7 pages, 6 color eps figures. Synchronous curve added. Typos and style corrected

Queering Music Therapy: Literature Review of Queer Music Therapy and Music Therapy Education

This capstone thesis presents current research on the queer (LGBTQ+) community and music therapy. Research on the education of music therapists in working with queer identified clients and patients as well as the current theories and recommendations when providing affirming music therapy for queer clients and patients is discussed. Queer theory is defined and its relationship to psychotherapy, expressive arts therapies, and music therapy is explored. This research shows that even though there is a current push for music therapists to create an affirming and therapeutic environment with queer clients and patients, there is a lack of research, education, and appropriate clinical recommendations for music therapists to adequately complete this task. Recommendations are made for further research on how music therapy is currently is utilized with queer individuals and how music therapists can be better educated on working with queer individuals. This paper suggests that growth in the body of knowledge on both areas, will advance the field of music therapy to become more diverse

Medical-Legal Partnerships to Support Continuity of Care for Immigrants Impacted by HIV: Lessons Learned from California.

The United States (US) has experienced a surge of anti-immigrant policies and rhetoric, raising concerns about the influence on health outcomes for immigrants living in the US. We conducted qualitative interviews (n = 20) with health care and social service providers, attorneys, and legal/policy experts in California to understand how agencies were maintaining access to HIV care and prevention for immigrant clients. We conducted a thematic analysis to describe the role of medical-legal partnerships (MLPs) and document best practices. Informants reported high demand for legal services. Referrals were facilitated by case managers, medical providers, and pre-existing relationships between clinics and legal agencies. Informants identified a need for additional funding and further guidance on screening for and supporting patients with legal needs. MLPs have the capacity to create sustainable, efficient, comprehensive structural changes that minimize barriers to HIV prevention and treatment and improve health outcomes among immigrant populations

Coordination Implications of Software Coupling in Open Source Projects

The effect of software coupling on the quality of software has been studied quite widely since the seminal paper on software modularity by Parnas [1]. However, the effect of the increase in software coupling on the coordination of the developers has not been researched as much. In commercial software development environments there normally are coordination mechanisms in place to manage the coordination requirements due to software dependencies. But, in the case of Open Source software such coordination mechanisms are harder to implement, as the developers tend to rely solely on electronic means of communication. Hence, an understanding of the changing coordination requirements is essential to the management of an Open Source project. In this paper we study the effect of changes in software coupling on the coordination requirements in a case study of a popular Open Source project called JBoss

The Pros and Cons of Prophylactic Central Compartment Lymph Node Dissection for Papillary Thyroid Carcinoma

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78140/1/thy.2009.1578.pd