Time-variation of Jupiter's internal magnetic field consistent with zonal wind advection

Determination of the time dependency (secular variation) of a planet’s magnetic field provides a window into understanding the dynamo responsible for generating its field. However, of the six Solar System planets with active dynamos, secular variation has been firmly established only for Earth. Here, we compare magnetic field observations of Jupiter from the Pioneer 10 and 11, Voyager 1 and Ulysses spacecraft (acquired 1973–1992) with a new Juno reference model (JRM09). We find a consistent, systematic change in Jupiter’s field over this 45-year time span, which cannot be explained by changes in the magnetospheric field or by changing the assumed rotation rate of Jupiter. Through a simplified forward model, we find that the inferred change in the field is consistent with advection of the field by Jupiter’s zonal winds, projected down to 93–95% of Jupiter’s radius (where the electrical conductivity of the hydrogen envelope becomes sufficient to advect the field). This result demonstrates that zonal wind interactions with Jupiter’s magnetic field are important and lends independent support to atmospheric and gravitational-field determinations of the profile of Jupiter’s deep winds

Identification of a neurovascular signaling pathway regulating seizures in mice

ObjectiveA growing body of evidence suggests that increased blood–brain barrier (BBB) permeability can contribute to the development of seizures. The protease tissue plasminogen activator (tPA) has been shown to promote BBB permeability and susceptibility to seizures. In this study, we examined the pathway regulated by tPA in seizures.MethodsAn experimental model of kainate‐induced seizures was used in genetically modified mice, including mice deficient in tPA (tPA−/−), its inhibitor neuroserpin (Nsp−/−), or both (Nsp:tPA−/−), and in mice conditionally deficient in the platelet‐derived growth factor receptor alpha (PDGFRα).ResultsCompared to wild‐type (WT) mice, Nsp−/− mice have significantly reduced latency to seizure onset and generalization; whereas tPA−/− mice have the opposite phenotype, as do Nsp:tPA−/− mice. Furthermore, interventions that maintain BBB integrity delay seizure propagation, whereas osmotic disruption of the BBB in seizure‐resistant tPA−/− mice dramatically reduces the time to seizure onset and accelerates seizure progression. The phenotypic differences in seizure progression between WT, tPA−/−, and Nsp−/− mice are also observed in electroencephalogram recordings in vivo, but absent in ex vivo electrophysiological recordings where regulation of the BBB is no longer necessary to maintain the extracellular environment. Finally, we demonstrate that these effects on seizure progression are mediated through signaling by PDGFRα on perivascular astrocytes.InterpretationTogether, these data identify a specific molecular pathway involving tPA‐mediated PDGFRα signaling in perivascular astrocytes that regulates seizure progression through control of the BBB. Inhibition of PDGFRα signaling and maintenance of BBB integrity might therefore offer a novel clinical approach for managing seizures.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/112290/1/acn3209.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/112290/2/acn3209-sup-0001-TableS1.pd

Systematic study of the SO(10) symmetry breaking vacua in the matrix model for type IIB superstrings

We study the properties of the space-time that emerges dynamically from the matrix model for type IIB superstrings in ten dimensions. We calculate the free energy and the extent of space-time using the Gaussian expansion method up to the third order. Unlike previous works, we study the SO(d) symmetric vacua with all possible values of d within the range $2 \le d \le 7$, and observe clear indication of plateaus in the parameter space of the Gaussian action, which is crucial for the results to be reliable. The obtained results indeed exhibit systematic dependence on d, which turns out to be surprisingly similar to what was observed recently in an analogous work on the six-dimensional version of the model. In particular, we find the following properties: i) the extent in the shrunken directions is given by a constant, which does not depend on d; ii) the ten-dimensional volume of the Euclidean space-time is given by a constant, which does not depend on d except for d = 2; iii) The free energy takes the minimum value at d = 3. Intuitive understanding of these results is given by using the low-energy effective theory and some Monte Carlo results.Comment: 33 pages, 10 figures; minor corrections, reference added. arXiv admin note: substantial text overlap with arXiv:1007.088

Time-variation of Jupiter's internal magnetic field consistent with zonal wind advection

Determination of the time dependency (secular variation) of a planet’s magnetic field provides a window into understanding the dynamo responsible for generating its field. However, of the six Solar System planets with active dynamos, secular variation has been firmly established only for Earth. Here, we compare magnetic field observations of Jupiter from the Pioneer 10 and 11, Voyager 1 and Ulysses spacecraft (acquired 1973–1992) with a new Juno reference model (JRM09). We find a consistent, systematic change in Jupiter’s field over this 45-year time span, which cannot be explained by changes in the magnetospheric field or by changing the assumed rotation rate of Jupiter. Through a simplified forward model, we find that the inferred change in the field is consistent with advection of the field by Jupiter’s zonal winds, projected down to 93–95% of Jupiter’s radius (where the electrical conductivity of the hydrogen envelope becomes sufficient to advect the field). This result demonstrates that zonal wind interactions with Jupiter’s magnetic field are important and lends independent support to atmospheric and gravitational-field determinations of the profile of Jupiter’s deep winds

Magazine and reader constructions of 'metrosexuality' and masculinity: a membership categorisation analysis

Since the launch of men's lifestyle magazines in the 1980s, academic literature has predominantly focused on them as a cultural phenomenon arising from entrepreneurial and commercial initiatives and/or as cultural texts that proffer representations of masculinity such as 'new lad' and 'new dad'. This paper steps aside from the focus on culture and, instead, treats magazine content as a discursive space in which gender and sexuality are oriented to, negotiated, and accomplished within and beyond the magazine itself (i.e. through readers' responses). Specifically, membership categorisation analysis is deployed to explore how the relatively new (and perhaps alternative) category for men - 'metrosexual' - is presented and received. Our analysis suggests that masculinity concerns are central in debates about 'metrosexuality', with self-identified 'metrosexuals' invoking heterosexual prowess and self-respect on the one hand, and critics (e.g. selfidentified 'real men') lamenting 'metrosexuality' for its perceived effeminacy and lack of authenticity on the other. Implications for understanding contemporary masculinities are discussed

Contextualised approaches to widening participation: a comparative case study of two UK universities

This article reports on institutional research at two contrasting UK universities, each with different foci in relation to widening participation (WP). The researchers sought to explore senior staff perspectives on the WP agenda at a time of unprecedented uncertainty and turmoil in the UK higher education sector. The research consisted primarily of interview data from university leaders responsible strategically for WP activity. The findings offer a nuanced narrative of the policy and practice of widening participation at two contrasting universities. Researchers found that the WP discourse itself is perceived as confused and discredited. Viewing ‘widening participation students’ as a homogenised group risks both the benefits of differentiated responses through discipline or subject areas and the benefits of more student-centred measures of success

BpaB, a Novel Protein Encoded by the Lyme Disease Spirochete\u27s Cp32 Prophages, Binds to Erp Operator 2 DNA

Borrelia burgdorferi produces Erp outer surface proteins throughout mammalian infection, but represses their synthesis during colonization of vector ticks. A DNA region 5′ of the start of erp transcription, Operator 2, was previously shown to be essential for regulation of expression. We now report identification and characterization of a novel erp Operator 2-binding protein, which we named BpaB. erp operons are located on episomal cp32 prophages, and a single bacterium may contain as many as 10 different cp32s. Each cp32 family member encodes a unique BpaB protein, yet the three tested cp32-encoded BpaB alleles all bound to the same DNA sequence. A 20-bp region of erp Operator 2 was determined to be essential for BpaB binding, and initial protein binding to that site was required for binding of additional BpaB molecules. A 36-residue region near the BpaB carboxy terminus was found to be essential for high-affinity DNA-binding. BpaB competed for binding to erp Operator 2 with a second B. burgdorferi DNA-binding protein, EbfC. Thus, cellular levels of free BpaB and EbfC could potentially control erp transcription levels

Precision calculation of magnetization and specific heat of vortex liquids and solids in type II superconductors

A new systematic calculation of magnetization and specific heat contributions of vortex liquids and solids (not very close to the melting line) is presented. We develop an optimized perturbation theory for the Ginzburg - Landau description of thermal fluctuations effects in the vortex liquids. The expansion is convergent in contrast to the conventional high temperature expansion which is asymptotic. In the solid phase we calculate first two orders which are already quite accurate. The results are in good agreement with existing Monte Carlo simulations and experiments. Limitations of various nonperturbative and phenomenological approaches are noted. In particular we show that there is no exact intersection point of the magnetization curves both in 2D and 3D.Comment: 4 pages, 3 figure