The Interwoven Evolution of the Early Keyboard and Baroque Culture

The purpose of this paper is to analyze the impact that Baroque society had in the development of the early keyboard. While the main timeframe is Baroque, a few references are made to the late Medieval Period in determining the reason for the keyboard to more prominently emerge in the musical scene. As Baroque society develops and new genres are formed, different keyboard instruments serve vital roles unique to their construction. These new roles also affect the way music was written for the keyboard as well. Advantages and disadvantages of each instrument are discussed, providing an analysis of what would have been either accepted or rejected by Baroque culture. While music is the main focus, other fine arts are mentioned, including architecture, poetry, politics, and others. My research includes primary and secondary resources retrieved from databases provided by Cedarville University. By demonstrating the relationship between Baroque society and early keyboard development, roles and music, this will be a helpful source in furthering the pianist\u27s understanding of the instrument he or she plays. It also serves pedagogical purposes in its analysis of context in helping a student interpret a piece written during this time period with these early keyboard instruments

Semi-direct Galois covers of the affine line

Let $k$ be an algebraically closed field of characteristic $p>0$. Let $G$ be $Z/\ell Z$ semi-direct product $Z/pZ$ where $\ell$ is a prime distinct from $p$. In this paper, we study Galois covers $\psi:Z \to P^1_k$ ramified only over $\infty$ with Galois group $G$. We find the minimal genus of a curve $Z$ that admits such a cover and show that it depends only on $\ell$, $p$, and the order $a$ of $\ell$ modulo $p$. We also prove that the number of curves $Z$ of this minimal genus which admit such a cover is at most $(p-1)/a$.Comment: minor changes in the contex

Probabilistic weighting of perspectives in dyadic communication

In successful communication, speakers tailor their language tothe context and listeners make inferences about the speaker’sknowledge. Several current accounts propose that both speak-ers and listeners accomplish this by rational analysis of thestatistics in the environment, including their partner. Here weexamine perspective-taking behaviour in a dyadic conversationtask, where the same individuals act in the role of both speakerand listener. We model perspective-taking in both productionand comprehension, taking into account the dyadic situation.Our findings suggest that conversational partners weight theirown perspective more than the partner’s when speaking, andthe partner’s perspective more than their own when listening.We also find that in both production and comprehension, con-versational partners change the weighting of perspectives overtime, moving towards relying more on the partner’s perspec-tive at the expense of their own perspective. Surprisingly, wefind little evidence that listeners or speakers adapt to the id-iosyncratic statistics of their partner’s linguistic behaviour

Acute and chronic effects of multivitamin/mineral supplementation on objective and subjective energy measures

Background: Vitamins and minerals play an essential role within many cellular processes including energy production and metabolism. Previously, supplementation with a multivitamin/mineral (MVM) for ≥28 days resulted in improvements to cognition and subjective state. We have also demonstrated shifts in metabolism during cognitively demanding tasks following MVM in females, both acutely and following 8-week supplementation. The current study aimed to assess these effects further in males and females using metabolically challenging exercise and cognitive tasks. Methods: The current randomised, placebo-controlled, parallel groups study investigated the effects of a MVM complex in 82 healthy young (18-35y) exercisers. Subjective ratings and substrate metabolism were assessed during 30 min each of increasingly effortful incremental exercise and demanding cognitive tasks. Assessments took place on acute study days following a single dose (Day 1) of MVM, containing 3 times recommended daily allowance of water-soluble vitamins plus CoQ10, and following 4-week supplementation (Day 28). Results: Energy expenditure (EE) was increased during cognitive tasks following MVM across Day 1 and Day 28, with greater effects in males. In males, MVM also increased carbohydrate oxidation and energy expenditure during exercise across Day 1 and Day 28. In females, mental tiredness was lower during exercise; increases in physical tiredness following 30 min of exercise were attenuated; and stress ratings following cognitive tasks were reduced following MVM. In males, MVM only lowered mental tiredness following 10 min of exercise. These effects were apparent irrespective of day, but effects on mental tiredness were greater on Day 28. Ferritin levels were also higher on Day 28 in those receiving MVM. Conclusion: These findings extend on existing knowledge, demonstrating increased carbohydrate oxidation and increased energy expenditure in males following MVM supplementation for the first time. Importantly, they show modulation of energy expenditure and subjective tiredness following a single dose, providing further evidence for acute effects of MVM. Differential effects in men and women suggest that sex may play an important role in the effects of MVM on energy metabolism and should be considered in future research. Trial registration: ClinicalTrials.gov, NCT03003442. Registered 22nd November 2016 – retrospectively registere

Male-Male Clasping May Be Part of an Alternative Reproductive Tactic in Xenopus laevis

Male Xenopus laevis frogs have been observed to clasp other males in a sustained, amplectant position, the purpose of which is unknown. We examined three possible hypotheses for this counter-intuitive behavior: 1) clasping males fail to discriminate the sex of the frogs they clasp; 2) male-male clasping is an aggressive or dominant behavior; or 3) that males clasp other males to gain proximity to breeding events and possibly engage in sperm competition. Our data, gathered through a series of behavioral experiments in the laboratory, refute the first two hypotheses. We found that males did not clasp indiscriminately, but showed a sex preference, with most males preferentially clasping a female, but a proportion preferentially clasping another male. Males that clasped another male when there was no female present were less likely to "win" reproductive access in a male-male-female triad, indicating that they did not establish dominance through clasping. However, those males did gain proximity to oviposition by continued male-male clasping in the presence of the female. Thus, our findings are consistent with, but cannot confirm, the third hypothesis of male-male clasping as an alternative reproductive tactic

KSHV-TK is a tyrosine kinase that disrupts focal adhesions and induces Rho-mediated cell contraction.

This is the accepted manuscript. The final version is available from Wiley at http://onlinelibrary.wiley.com/doi/10.15252/embj.201490358/abstract.Paradoxically, the thymidine kinase (TK) encoded by Kaposi sarcoma-associated herpesvirus (KSHV) is an extremely inefficient nucleoside kinase, when compared to TKs from related herpesviruses. We now show that KSHV-TK, in contrast to HSV1-TK, associates with the actin cytoskeleton and induces extensive cell contraction followed by membrane blebbing. These dramatic changes in cell morphology depend on the auto-phosphorylation of tyrosines 65, 85 and 120 in the N-terminus of KSHV-TK. Phosphorylation of tyrosines 65/85 and 120 results in an interaction with Crk family proteins and the p85 regulatory subunit of PI3-Kinase, respectively. The interaction of Crk with KSHV-TK leads to tyrosine phoshorylation of this cellular adaptor. Auto-phosphorylation of KSHV-TK also induces a loss of FAK and paxillin from focal adhesions, resulting in activation of RhoA-ROCK signalling to myosin II and cell contraction. In the absence of FAK or paxillin, KSHV-TK has no effect on focal adhesion integrity or cell morphology. Our observations demonstrate that by acting as a tyrosine kinase, KSHV-TK modulates signalling and cell morphology.This work was supported by Medical Research Council grant G0701185 to PGS and MBG. M.W is supported by Cancer Research UK