Food additives and children's behaviour: evidence based policy at the margins of certainty

The possible effects of food additives (specifically artificial colours) have been debated for over 30 years. The evidence accumulated suggests that for some children with attention deficit hyperactivity disorder (ADHD) food colours exacerbate their condition. Two studies undertaken by a research group at the University of Southampton have extended these findings to the effects on hyperactivity in children from the general population who do not show ADHD. This article reviews the response from policy-makers to these findings and concludes that the failure to impose a mandatory ban on the six food colours in the Southampton study is inadequate and that such a ban would be an appropriate application of the precautionary principle when the evidence is considered to be at the margins of certaint

Living by the sword: the archaeology of Brisley Farm, Ashford, Kent

The discovery of two warrior burials, during excavations at Brisley Farm in 2001, heralded the start of a decade of research on these exceptional finds. The burials were interred about a generation apart, at c AD 10 and c AD 50 and are the latest known warrior burials from Britain, with clear national and international significance. However, these finds are just the centrepiece of investigations that have revealed widespread evidence of the development of the ancient landscape spanning some three millennia. At its height, in the Late Iron Age, Brisley Farm was the focus for an exceptional settlement that combined interrelated ritual and domestic elements and has revealed evidence of everyday life, and death, on the eve of the Roman Conquest. This volume presents the findings of ten archaeological sites investigated at Brisley Farm, Chilmington Green, Ashford, between 1998 and 2009, and at a nearby site, Christchurch CE High School, Ashford, excavated in 2003. Evidence for activity ranges from the Mesolithic through to the early post-medieval, with a focus on the development from a Bronze Age through to medieval landscape

Dietary influences on cognitive development and behaviour in children

There are a number of ways in which food can influence behaviour, including malnutrition, types of diet, eating habits, pharmacological effects, food allergy, fatty acid deficiency and possibly food additives. The range of behaviour affected is also wide, and includes attention, conduct disorder and mood. A particular focus of interest has been the effects of food on hyperactivity in children. There is some initial evidence that fatty acids may influence hyperactivity in children with specific learning disabilities. The findings also suggest that some food additives (colourings, flavourings and preservatives) may increase hyperactivity in children with behaviour problems. For children showing behaviour problems such as hyperactivity the use of dietary manipulation tends to be a more acceptable approach to treatment than the use of drugs. However, there needs to be awareness of the dangers of the use of unsupervised restriction diets with children, and the use of dietary treatments alone is not likely to be sufficient treatment for many children with attention-deficit hyperactivity disorder. A study is currently underway to investigate the possible effects of additives on behaviour in the general population of childre

Discrepancies between registration and publication of randomised controlled trials: an observational study

Abstract OBJECTIVES: To determine the consistency between information contained in the registration and publication of randomised controlled trials (RCTs). DESIGN: An observational study of RCTs published between May 2011 and May 2012 in the British Medical Journal (BMJ) and the Journal of the American Medical Association (JAMA) comparing registry data with publication data. PARTICIPANTS AND SETTINGS: Data extracted from published RCTs in BMJ and JAMA. MAIN OUTCOME MEASURES: Timing of trial registration in relation to completion of trial data collection and publication. Registered versus published primary and secondary outcomes, sample size. RESULTS: We identified 40 RCTs in BMJ and 36 in JAMA. All 36 JAMA trials and 39 (98%) BMJ trials were registered. All registered trials were registered prior to publication. Thirty-two (82%) BMJ trials recorded the date of data completion; of these, in two trials the date of trial registration postdated the registered date of data completion. There were discrepancies between primary outcomes declared in the trial registry information and in the published paper in 18 (47%) BMJ papers and seven (19%) JAMA papers. The original sample size stated in the trial registration was achieved in 24 (60%) BMJ papers and 21 (58%) JAMA papers. CONCLUSIONS: Compulsory registration of RCTs is meaningless if the content of registry information is not complete or if discrepancies between registration and publication are not reported. This study demonstrates that discrepancies in primary and secondary outcomes and sample size between trial registration and publication remain commonplace, giving further strength to the World Health Organisation's argument for mandatory completion of a minimum number of compulsory fields

Genotype moderates the impact of food additives on hyperactive behavior in children

Introduction: The claim of a relationship between artificial food color and additive (AFCs) intake and behavior is highly contentious. We have shown in a previous population-based trial with 3yo children adverse effects of food additives on parentally-rated hyperactive behaviour (Bateman et al, 2004). The possible role of genetic polymorphisms in moderating this adverse effect has not been previously examined. Methods A randomised, double blind, placebo-controlled, within subject crossover food challenge was used for 144, 8 to 9 year old children and 153, 3 year old children. Following baseline assessment children were placed on a diet eliminating food additives and a benzoate preservative for 6 weeks during which time they were challenged for weekly periods with either a placebo mix or a drink containing sodium benzoate (45mg daily) and one of two mixes of AFCs.: Results: The T939C and Thr105Ile polymorphisms of the histamine N-methyltransferase gene (HNMT) moderated the adverse effect s of AFCs but the polymorphisms in catecholamine genes COMT Val108Met and ADRA2A C1291G did not. These findings point to a possible role for histamine in mediating the effects of food additives and help to explain why there has been inconsistency between previous studies. Conclusions: Genes influencing a range of neurotransmitter systems and their interplay with environmental factors, such as diet, need to be examined to understand genetic influences on hyperactivity.<br/

Formation of the first three gravitational-wave observations through isolated binary evolution

During its first 4 months of taking data, Advanced LIGO has detected gravitational waves from two binary black hole mergers, GW150914 and GW151226, along with the statistically less significant binary black hole merger candidate LVT151012. We use our rapid binary population synthesis code COMPAS to show that all three events can be explained by a single evolutionary channel -- classical isolated binary evolution via mass transfer including a common envelope phase. We show all three events could have formed in low-metallicity environments (Z = 0.001) from progenitor binaries with typical total masses $\gtrsim 160 M_\odot$, $\gtrsim 60 M_\odot$ and $\gtrsim 90 M_\odot$, for GW150914, GW151226, and LVT151012, respectively.Comment: Published in Nature Communication