348 research outputs found
The development of iHARP: a multiple instruction issue processor chip
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Myelination of parvalbumin interneurons: a parsimonious locus of pathophysiological convergence in schizophrenia
Schizophrenia is a debilitating psychiatric disorder characterized by positive, negative and cognitive symptoms. Despite more than a century of research, the neurobiological mechanism underlying schizophrenia remains elusive. White matter abnormalities and interneuron dysfunction are the most widely replicated cellular neuropathological alterations in patients with schizophrenia. However, a unifying model incorporating these findings has not yet been established. Here, we propose that myelination of fast-spiking parvalbumin (PV) interneurons could be an important locus of pathophysiological convergence in schizophrenia. Myelination of interneurons has been demonstrated across a wide diversity of brain regions and appears highly specific for the PV interneuron subclass. Given the critical influence of fast-spiking PV interneurons for mediating oscillations in the gamma frequency range (~30–120 Hz), PV myelination is well positioned to optimize action potential fidelity and metabolic homeostasis. We discuss this hypothesis with consideration of data from human postmortem studies, in vivo brain imaging and electrophysiology, and molecular genetics, as well as fundamental and translational studies in rodent models. Together, the parvalbumin interneuron myelination hypothesis provides a falsifiable model for guiding future studies of schizophrenia pathophysiology.Molecular Psychiatry advance online publication, 20 September 2016; doi:10.1038/mp.2016.147
Laser collimation of an atomic gallium beam
The linear-perpendicular-linear polarization gradient technique was used for investigating laser collimation of a gallium atomic beam in one dimension. The full angular divergence of the atomic beam was reduced to 0.3 mrad by operating on a particular electron transition at 294.45 nm. The transverse velocity of the atoms was reduced to 11 cm/s, which was about half of the Doppler cooling limit. The one-dimensional kinetic energy of atoms was reduced to 6 neV. The transition state exhibited optical pumping of the atoms by the cooling laser
Measurement of the hyperfine structure of the 4d2D 3/2,5/2 levels and isotope shifts of the 4p2p 3/2 ? 4d2D3/2 and 4p2p 3/2 ? 4d2D5/2 transitions in gallium 69 and 71
The hyperfine structure of the 4d2D3/2,5/2 levels of 69,71Ga is determined. The 4p2P3/2 ? 4d2D3/2 (294.50-nm) and 4p2P3/2 ? 4d2D5/2 (294.45-nm) transitions are studied by laser-induced fluorescence in an atomic Ga beam. The hyperfine A constant measured for the 4d2D5/2 level is 77.3 ± 0.9 MHz for 69Ga and 97.9 ± 0.7 MHz for 71Ga (3s errors). The A constant measured for the 4d2D3/2 level is -36.3 ± 2.2 MHz for 69Ga and -46.2 ± 3.8 MHz for 71Ga. These measurements correct sign errors in the previous determination of these constants. For 69Ga the hyperfine B constants measured for the 4d2D5/2 and the 4d2D 3/2 levels are 5.3 ± 4.1 MHz and 4.6 ± 4.2 MHz, respectively. The isotope shift is determined to be 114 ± 8 MHz for the 4p2P3/2 ? 4d2D3/2 transition and 115 ± 7 MHz for the 4p2P3/2 ± 4d 2D5/2 transition. The lines of 71Ga are shifted to the blue. This is in agreement with previous measurement
Nanolithography with metastable neon atoms: Enhanced rate of contamination resist formation for nanostructure fabrication
We report a sevenfold improvement in the rate of contamination resist formation over previous experiments by using metastable neon atoms for nanolithography. Chemically assisted ion beam etching was used to transfer the resist pattern into the substrate. We demonstrate the fabrication of 50-nm-wide features in GaAs with well-defined edges and an aspect ratio \u3e2:1. These are the best resolution and highest aspect ratio features that have been achieved with metastable atom lithography. The resist formation rate by the metastable neon atoms and the etch selectivity of the contamination resist with GaAs were measured
Noncommutativity from the string perspective: modification of gravity at a mm without mm sized extra dimensions
We explore how the IR pathologies of noncommutative field theory are resolved
when the theory is realized as open strings in background B-fields:
essentially, since the IR singularities are induced by UV/IR mixing, string
theory brings them under control in much the same way as it does the UV
singularities. We show that at intermediate scales (where the Seiberg-Witten
limit is a good approximation) the theory reproduces the noncommutative field
theory with all the (un)usual features such as UV/IR mixing, but that outside
this regime, in the deep infra-red, the theory flows continuously to the
commutative theory and normal Wilsonian behaviour is restored. The resulting
low energy physics resembles normal commutative physics, but with additional
suppressed Lorentz violating operators. We also show that the phenomenon of
UV/IR mixing occurs for the graviton as well, with the result that, in
configurations where Planck's constant receives a significant one-loop
correction (for example brane-induced gravity), the distance scale below which
gravity becomes non-Newtonian can be much greater than any compact dimensions.Comment: 30 pages. Slight revision: clarified some points and added a
referenc
Quasi-1D dynamics and nematic phases in the 2D Emery model
We consider the Emery model of a
Cu-O plane of the high temperature superconductors. We show that in a
strong-coupling limit, with strong Coulomb repulsions between electrons on
nearest-neighbor O sites, the electron-dynamics is strictly one dimensional,
and consequently a number of asymptotically exact results can be obtained
concerning the electronic structure. In particular, we show that a nematic
phase, which spontaneously breaks the point- group symmetry of the square
lattice, is stable at low enough temperatures and strong enough coupling.Comment: 8 pages, 5 eps figures; revised manuscript with more detailed
discussions; two new figures and three edited figuresedited figures; 14
references; new appendix with a detailed proof of the one-dimensional
dynamics of the system in the strong coupling limi
Power as an enabling force:An integrative review
The power literature’s focus on criticizing power relations comes at the cost of deliberate attempts to improve organizational practices. How can critical performativity and other scholars address power as an enabling force, thereby also allowing for more engagement with practitioners? We integrate the literature on power in and around organizations with studies of organizational change and behavior. By focusing on enabling instead of restrictive power, we draw attention to the potentially pivotal role of key actors—managers, other practitioners, and scholars—in fostering empowerment and emancipation within organizations. Our review points at four social mechanisms that drive enabling power: formal authority, language-shaping-action, community formation, and the dynamics of safety and trust. Furthermore, we identify various types of actions that can trigger these mechanisms that, in turn, may give rise to outcomes such as empowerment and emancipation. The main contribution of this article involves an integrated framework of power as an enabling force. By synthesizing various separate discourses, this framework extends prior reviews focusing on power-over, resulting in a systemic understanding of enabling power and thereby creating novel avenues for research on power. The integrative framework also provides a foundation for an intervention-oriented body of knowledge on enabling power.</p
Intersecting Brane Worlds at One Loop
We develop techniques for one-loop diagrams on intersecting branes. The
one-loop propagator of chiral intersection states on D6 branes is calculated
exactly and its finiteness is shown to be guaranteed by RR tadpole
cancellation. The result is used to demonstrate the expected softening of power
law running of Yukawa couplings at the string scale. We also develop methods to
calculate arbitrary N-point functions at one-loop, including those without
gauge bosons in the loop. These techniques are also applicable to heterotic
orbifold models.Comment: 35 pages, 3 figures; added reference, corrected typos, JHEP styl
The three-nucleon bound state using realistic potential models
The bound states of H and He have been calculated using the Argonne
plus the Urbana three-nucleon potential. The isospin state
have been included in the calculations as well as the - mass difference.
The H-He mass difference has been evaluated through the charge
dependent terms explicitly included in the two-body potential. The calculations
have been performed using two different methods: the solution of the Faddeev
equations in momentum space and the expansion on the correlated hyperspherical
harmonic basis. The results are in agreement within 0.1% and can be used as
benchmark tests. Results for the CD-Bonn interaction are also presented. It is
shown that the H and He binding energy difference can be predicted
model independently.Comment: 5 pages REVTeX 4, 1 figures, 6 table
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