383 research outputs found
Broadband near-infrared astronomical spectrometer calibration and on-sky validation with an electro-optic laser frequency comb
The quest for extrasolar planets and their characterisation as well as
studies of fundamental physics on cosmological scales rely on capabilities of
high-resolution astronomical spectroscopy. A central requirement is a precise
wavelength calibration of astronomical spectrographs allowing for extraction of
subtle wavelength shifts from the spectra of stars and quasars. Here, we
present an all-fibre, 400 nm wide near-infrared frequency comb based on
electro-optic modulation with 14.5 GHz comb line spacing. Tests on the
high-resolution, near-infrared spectrometer GIANO-B show a photon-noise limited
calibration precision of <10 cm/s as required for Earth-like planet detection.
Moreover, the presented comb provides detailed insight into particularities of
the spectrograph such as detector inhomogeneities and differential spectrograph
drifts. The system is validated in on-sky observations of a radial velocity
standard star (HD221354) and telluric atmospheric absorption features. The
advantages of the system include simplicity, robustness and turn-key operation,
features that are valuable at the observation sites
Frequency comb up- and down-conversion in a synchronously-driven optical microresonator
Optical frequency combs are key to optical precision measurements. While most
frequency combs operate in the near-infrared regime, many applications require
combs at mid-infrared, visible or even ultra-violet wavelengths. Frequency
combs can be transferred to other wavelengths via nonlinear optical processes,
however, this becomes exceedingly challenging for high-repetition rate
frequency combs. Here, it is demonstrated that a synchronously driven high-Q
microresonator with a second-order optical nonlinearity can efficiently convert
high-repetition rate near-infrared frequency combs to visible, ultra-violet and
mid-infrared wavelengths providing new opportunities for microresonator and
electro-optic combs in applications including molecular sensing, astronomy, and
quantum optics
PPERFORMANCE EVALUATION OF TWO MIPS FOR THE SPE-LC-UV DETERMINATION OF p-[18F]MPPF IN PLASMA
FP6 STRP 516984 MI-lab-on-chi
DEVELOPMENT AND VALIDATION OF A METHOD FOR THE LC DETERMINATION p-[18F]MPPF IN PLASMA USING A MISPE
Peer reviewe
Ordered and deterministic cancer genome evolution after p53 loss
Although p53 inactivation promotes genomic instability1 and presents a route to malignancy for more than half of all human cancers2,3, the patterns through which heterogenous TP53 (encoding human p53) mutant genomes emerge and influence tumorigenesis remain poorly understood. Here, in a mouse model of pancreatic ductal adenocarcinoma that reports sporadic p53 loss of heterozygosity before cancer onset, we find that malignant properties enabled by p53 inactivation are acquired through a predictable pattern of genome evolution. Single-cell sequencing and in situ genotyping of cells from the point of p53 inactivation through progression to frank cancer reveal that this deterministic behaviour involves four sequential phases-Trp53 (encoding mouse p53) loss of heterozygosity, accumulation of deletions, genome doubling, and the emergence of gains and amplifications-each associated with specific histological stages across the premalignant and malignant spectrum. Despite rampant heterogeneity, the deletion events that follow p53 inactivation target functionally relevant pathways that can shape genomic evolution and remain fixed as homogenous events in diverse malignant populations. Thus, loss of p53-the 'guardian of the genome'-is not merely a gateway to genetic chaos but, rather, can enable deterministic patterns of genome evolution that may point to new strategies for the treatment of TP53-mutant tumours
Energy Resolution Performance of the CMS Electromagnetic Calorimeter
The energy resolution performance of the CMS lead tungstate crystal electromagnetic calorimeter is presented. Measurements were made with an electron beam using a fully equipped supermodule of the calorimeter barrel. Results are given both for electrons incident on the centre of crystals and for electrons distributed uniformly over the calorimeter surface. The electron energy is reconstructed in matrices of 3 times 3 or 5 times 5 crystals centred on the crystal containing the maximum energy. Corrections for variations in the shower containment are applied in the case of uniform incidence. The resolution measured is consistent with the design goals
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