Chiral order and fluctuations in multi-flavour QCD

Multi-flavour (N_f>=3) Chiral Perturbation Theory (ChPT) may exhibit instabilities due to vacuum fluctuations of sea q-bar q pairs. Keeping the fluctuations small would require a very precise fine-tuning of the low-energy constants L_4 and L_6 to L_4[crit](M_rho) = - 0.51 * 10^(-3), and L_6[crit](M_rho) = - 0.26 * 10^(-3). A small deviation from these critical values -- like the one suggested by the phenomenology of OZI-rule violation in the scalar channel -- is amplified by huge numerical factors inducing large effects of vacuum fluctuations. This would lead in particular to a strong N_f-dependence of chiral symmetry breaking and a suppression of multi-flavour chiral order parameters. A simple resummation is shown to cure the instability of N_f>=3 ChPT, but it modifies the standard expressions of some O(p^2) and O(p^4) low-energy parameters in terms of observables. On the other hand, for r=m_s/m > 15, the two-flavour condensate is not suppressed, due to the contribution induced by massive vacuum s-bar s pairs. Thanks to the latter, the standard two-flavour ChPT is protected from multi-flavour instabilities and could provide a well-defined expansion scheme in powers of non-strange quark masses.Comment: Published versio

Analysis and interpretation of new low-energy Pi-Pi scattering data

The recently published E865 data on charged K_e4 decays and Pi-Pi phases are reanalyzed to extract values of the two S-wave scattering lengths, of the subthreshold parameters alpha and beta, of the low-energy constants l3-bar and l4-bar as well as of the main two-flavour order parameters: and F_pi in the limit m_u = m_d = 0 taken at the physical value of the strange quark mass. Our analysis is exclusively based on direct experimental information on Pi-Pi phases below 800 MeV and on the new solutions of the Roy equations by Ananthanarayan et al. The result is compared with the theoretical prediction relating 2 a_0^0 - 5 a_0^2 and the scalar radius of the pion, which was obtained in two-loop Chiral Perturbation Theory. A discrepancy at the 1-sigma level is found and commented upon.Comment: Published version, to appear in Eur. Phys. J.

IR Kuiper Belt Constraints

We compute the temperature and IR signal of particles of radius $a$ and albedo $\alpha$ at heliocentric distance $R$, taking into account the emissivity effect, and give an interpolating formula for the result. We compare with analyses of COBE DIRBE data by others (including recent detection of the cosmic IR background) for various values of heliocentric distance, $R$, particle radius, $a$, and particle albedo, $\alpha$. We then apply these results to a recently-developed picture of the Kuiper belt as a two-sector disk with a nearby, low-density sector (40<R<50-90 AU) and a more distant sector with a higher density. We consider the case in which passage through a molecular cloud essentially cleans the Solar System of dust. We apply a simple model of dust production by comet collisions and removal by the Poynting-Robertson effect to find limits on total and dust masses in the near and far sectors as a function of time since such a passage. Finally we compare Kuiper belt IR spectra for various parameter values.Comment: 34 pages, LaTeX, uses aasms4.sty, 11 PostScript figures not embedded. A number of substantive comments by a particularly thoughtful referee have been addresse

Composite Fermions in Modulated Structures: Transport and Surface Acoustic Waves

Motivated by a recent experiment of Willett et al. [Phys. Rev. Lett. 78, 4478 (1997)], we employ semiclassical composite-fermion theory to study the effect of a periodic density modulation on a quantum Hall system near Landau level filling factor nu=1/2. We show that even a weak density modulation leads to dramatic changes in surface-acoustic-wave (SAW) propagation, and propose an explanation for several key features of the experimental observations. We predict that properly arranged dc transport measurements would show a structure similar to that seen in SAW measurements.Comment: Version published in Phys. Rev. Lett. Figures changed to show SAW velocity shift. LaTeX, 5 pages, two included postscript figure

Cancer therapeutic potential of combinatorial immuno- and vaso-modulatory interventions

Currently, most of the basic mechanisms governing tumor-immune system interactions, in combination with modulations of tumor-associated vasculature, are far from being completely understood. Here, we propose a mathematical model of vascularized tumor growth, where the main novelty is the modeling of the interplay between functional tumor vasculature and effector cell recruitment dynamics. Parameters are calibrated on the basis of different in vivo immunocompromised Rag1-/- and wild-type (WT) BALB/c murine tumor growth experiments. The model analysis supports that tumor vasculature normalization can be a plausible and effective strategy to treat cancer when combined with appropriate immuno-stimulations. We find that improved levels of functional tumor vasculature, potentially mediated by normalization or stress alleviation strategies, can provide beneficial outcomes in terms of tumor burden reduction and growth control. Normalization of tumor blood vessels opens a therapeutic window of opportunity to augment the antitumor immune responses, as well as to reduce the intratumoral immunosuppression and induced-hypoxia due to vascular abnormalities. The potential success of normalizing tumor-associated vasculature closely depends on the effector cell recruitment dynamics and tumor sizes. Furthermore, an arbitrary increase of initial effector cell concentration does not necessarily imply a better tumor control. We evidence the existence of an optimal concentration range of effector cells for tumor shrinkage. Based on these findings, we suggest a theory-driven therapeutic proposal that optimally combines immuno- and vaso-modulatory interventions

A generalized Poisson and Poisson-Boltzmann solver for electrostatic environments

The computational study of chemical reactions in complex, wet environments is critical for applications in many fields. It is often essential to study chemical reactions in the presence of applied electrochemical potentials, taking into account the non-trivial electrostatic screening coming from the solvent and the electrolytes. As a consequence the electrostatic potential has to be found by solving the generalized Poisson and the Poisson-Boltzmann equation for neutral and ionic solutions, respectively. In the present work solvers for both problems have been developed. A preconditioned conjugate gradient method has been implemented to the generalized Poisson equation and the linear regime of the Poisson-Boltzmann, allowing to solve iteratively the minimization problem with some ten iterations of a ordinary Poisson equation solver. In addition, a self-consistent procedure enables us to solve the non-linear Poisson-Boltzmann problem. Both solvers exhibit very high accuracy and parallel efficiency, and allow for the treatment of different boundary conditions, as for example surface systems. The solver has been integrated into the BigDFT and Quantum-ESPRESSO electronic-structure packages and will be released as an independent program, suitable for integration in other codes

Optical Spectroscopic Survey of High-latitude WISE-selected Sources

We report on the results of an optical spectroscopic survey at high Galactic latitude (|b| ≥ 30°) of a sample of WISE-selected targets, grouped by WISE W1 (λ_eff = 3.4 μm) flux, which we use to characterize the sources WISE detected. We observed 762 targets in 10 disjoint fields centered on ultraluminous infrared galaxy candidates using DEIMOS on Keck II. We find 0.30 ± 0.02 galaxies arcmin–2 with a median redshift of z = 0.33 ± 0.01 for the sample with W1 ≥ 120 μJy. The foreground stellar densities in our survey range from 0.23 ± 0.07 arcmin–2 to 1.1 ± 0.1 arcmin–2 for the same sample. We obtained spectra that produced science grade redshifts for ≥90% of our targets for sources with W1 flux ≥120 μJy that also had an i-band flux gsim 18 μJy. We used this for targeting very preliminary data reductions available to the team in 2010 August. Our results therefore present a conservative estimate of what is possible to achieve using WISE's Preliminary Data Release for the study of field galaxies

Composite Fermions with Orbital Magnetization

For quantum Hall systems, in the limit of large magnetic field (or equivalently small electron band mass $m_b$), the static response of electrons to a spatially varying magnetic field is largely determined by kinetic energy considerations. This response is not correctly given in existing approximations based on the Fermion Chern-Simons theory of the partially filled Landau level. We remedy this problem by attaching an orbital magnetization to each fermion to separate the current into magnetization and transport contributions, associated with the cyclotron and guiding center motions respectively. This leads to a Chern-Simons Fermi liquid description of the $\nu=\frac{1}{2m}$ state which correctly predicts the $m_b$ dependence of the static and dynamic response in the limit $m_b \rightarrow 0$.Comment: 4 pages, RevTeX, no figure