Heel de mens met licht

Rede, in verkorte vorm uitgesproken ter gelegenheid van het aanvaarden van het ambt van bijzonder hoogleraar met als leeropdracht Fotodynamische Therapie aan het Erasmus MC, faculteit van de Erasmus Universiteit Rotterdam op 28 mei 200

Can Cassini Magnetic Field Measurements Be Used To Find The Rotation Period of Saturn’s Interior?

We investigate the determination of the rotation period of Saturn's interior using magnetic field measurements from Cassini. First, we vary the rotation period and search for the period that yields the smallest rms misfit of a magnetic field model to the data. Second, we search for the period that yields the most power in the non-axisymmetric components of a magnetic field model. Neither method enables us to determine the rotation period. However, we are able to place a bound on the magnitude of the non-axisymmetric component of Saturn's magnetic field finding it to be no greater than 4–5% of the axisymmetric component.Earth and Planetary Science

Experimental benchmark and numerical validation of a free heaving airfoil

In order to validate fluid-structure interaction solvers, a one degree of freedom (1 DOF) aeroelastic experiment is performed. A rigid wing with an harmonically actuated flap, is suspended by springs to allow a free heaving motion. Displacements and time dependent aerodynamic forces are measured for reduced flap frequencies ranging from k = 0.1 to k = 0.3. Simulations with three codes of different complexity level are performed for validation purposes: theodorsens model, a 2D panel code and 2D URANS, all coupled to a 1 DOF structural model. Results presented by bode diagrams, show differences in both the displacement and the lift between numerical work and experiment. Although there is an offset, consistency is found between displacements, forces and phase angles in the system for all simulations and the experiment

Broadband hyperspectral imaging for breast tumor detection using spectral and spatial information

Complete tumor removal during breast-conserving surgery remains challenging due to the lack of optimal intraoperative margin assessment techniques. Here, we use hyperspectral imaging for tumor detection in fresh breast tissue. We evaluated different wavelength ranges and two classification algorithms; a pixel-wise classification algorithm and a convolutional neural network that combines spectral and spatial information. The highest classification performance was obtained using the full wavelength range (450-1650nm). Adding spatial information mainly improved the differentiation of tissue classes within the malignant and healthy classes. High sensitivity and specificity were accomplished, which offers potential for hyperspectral imaging as a margin assessment technique to improve surgical outcome. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreemen

Method for coregistration of optical measurements of breast tissue with histopathology : the importance of accounting for tissue deformations

For the validation of optical diagnostic technologies, experimental results need to be benchmarked against the gold standard. Currently, the gold standard for tissue characterization is assessment of hematoxylin and eosin (H&E)-stained sections by a pathologist. When processing tissue into H&E sections, the shape of the tissue deforms with respect to the initial shape when it was optically measured. We demonstrate the importance of accounting for these tissue deformations when correlating optical measurement with routinely acquired histopathology. We propose a method to register the tissue in the H&E sections to the optical measurements, which corrects for these tissue deformations. We compare the registered H&E sections to H&E sections that were registered with an algorithm that does not account for tissue deformations by evaluating both the shape and the composition of the tissue and using microcomputer tomography data as an independent measure. The proposed method, which did account for tissue deformations, was more accurate than the method that did not account for tissue deformations. These results emphasize the need for a registration method that accounts for tissue deformations, such as the method presented in this study, which can aid in validating optical techniques for clinical use. (C) The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License

Diffuse reflection spectroscopy at the fingertip:design and performance of a compact side-firing probe for tissue discrimination during colorectal cancer surgery

Optical technologies are widely used for tissue sensing purposes. However, maneuvering conventional probe designs with flat-tipped fibers in narrow spaces can be challenging, for instance during pelvic colorectal cancer surgery. In this study, a compact side-firing fiber probe was developed for tissue discrimination during colorectal cancer surgery using diffuse reflectance spectroscopy. The optical behavior was compared to flat-tipped fibers using both Monte Carlo simulations and experimental phantom measurements. The tissue classification performance was examined using freshly excised colorectal cancer specimens. Using the developed probe and classification algorithm, an accuracy of 0.92 was achieved for discriminating tumor tissue from healthy tissue