Evolutionary history of four binary blue stragglers from the globular clusters \omega Cen, M55, 47 Tuc and NGC 6752

Context. Origin and evolution of blue stragglers in globular clusters is still a matter of debate. Aims. The aim of the present investigation is to reproduce the evolutionary history of four binary blue stragglers in four different clusters, for which precise values of global parameters are known. Methods. Using the model for cool close binary evolution, developed by one of us (KS), progenitors of all investigated binaries were found and their parameters evolved into the presently observed values. Results. The results show that the progenitors of the binary blue stragglers are cool close binaries with period of a few days, which transform into stragglers by rejuvenation of the initially less massive component by mass transfer from its more massive companion overflowing the inner critical Roche surface. The parameters of V209 from \omega Cen indicate that the binary is substantially enriched in helium. This is an independent and strong evidence for the existence of the helium rich subpopulation in this cluster.Comment: Accepted by Astronomy and Astrophysic

The radio lighthouse CU Virginis: the spindown of a single main sequence star

The fast rotating star CU Virginis is a magnetic chemically peculiar star with an oblique dipolar magnetic field. The continuum radio emission has been interpreted as gyrosyncrotron emission arising from a thin magnetospheric layer. Previous radio observations at 1.4 GHz showed that a 100% circular polarized and highly directive emission component overlaps to the continuum emission two times per rotation, when the magnetic axis lies in the plane of the sky. This sort of radio lighthouse has been proposed to be due to cyclotron maser emission generated above the magnetic pole and propagating perpendicularly to the magnetic axis. Observations carried out with the Australia Telescope Compact Array at 1.4 and 2.5 GHz one year after this discovery show that this radio emission is still present, meaning that the phenomenon responsible for this process is steady on a timescale of years. The emitted radiation spans at least 1 GHz, being observed from 1.4 to 2.5 GHz. On the light of recent results on the physics of the magnetosphere of this star, the possibility of plasma radiation is ruled out. The characteristics of this radio lighthouse provides us a good marker of the rotation period, since the peaks are visible at particular rotational phases. After one year, they show a delay of about 15 minutes. This is interpreted as a new abrupt spinning down of the star. Among several possibilities, a quick emptying of the equatorial magnetic belt after reaching the maximum density can account for the magnitude of the breaking. The study of the coherent emission in stars like CU Vir, as well as in pre main sequence stars, can give important insight into the angular momentum evolution in young stars. This is a promising field of investigation that high sensitivity radio interferometers such as SKA can exploit.Comment: Accepted to MNRAS, 8 pages, 7 figures, updated versio

Localisation of the human hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA

We characterised the human hSuv3p protein belonging to the family of NTPases/helicases. In yeast mitochondria the hSUV3 orthologue is a component of the degradosome complex and participates in mtRNA turnover and processing, while in Caenorhabditis elegans the hSUV3 orthologue is necessary for viability of early embryos. Using immunofluorescence analysis, an in vitro mitochondrial uptake assay and sub‐fractionation of human mitochondria we show hSuv3p to be a soluble protein localised in the mitochondrial matrix. We expressed and purified recombinant hSuv3p protein from a bacterial expression system. The purified enzyme was capable of hydrolysing ATP with a Km of 41.9 µM and the activity was only modestly stimulated by polynucleotides. hSuv3p unwound partly hybridised dsRNA and dsDNA structures with a very strong preference for the latter. The presented analysis of the hSuv3p NTPase/helicase suggests that new functions of the protein have been acquired in the course of evolution

Analysis of instagram® posts referring to cleft lip

Background: Social media has become a source of medical information. Cleft lip and palate is a visible congenital anomaly. The aim of the study was to analyze Instagram® posts on the topic of cleft lip. Methods: Instagram® posts with “#cleftlip” from March 2014–March 2017 were accessed. Separate lists of expressions (hashtags, meaningful words, words with emojis or emojis alone) were prepared for primary posts and for replies. Thirty expressions statistically most frequent in primary versus secondary posts and 30 in secondary versus primary posts were identified (Group 1) as well as 30 English words or hashtags (Group 2), non-English words or hashtags (Group 3) and emojis (Group 4). The frequencies of expressions were compared (Z-test for the difference of two population proportions). Results: There were 34,129 posts, (5427 primary posts and 28,702 replies), containing 62,163 expressions, (35,004 in primary posts). The occurrence of all expressions was 454,162, (225,418 in primary posts and 228,744 in replies). Posts with positive expressions such as “beautiful”, “love”, “cute”, “great”, “awesome” occurred more often than these with negative ones. In replies all emojis were positive. Conclusions: Numerous Instagram® posts referring to cleft lip are published and do provoke discussion. People express their solidarity and sympathize with persons affected by cleft

The Role of Dysregulated miRNAs in the Pathogenesis, Diagnosis and Treatment of Age-Related Macular Degeneration

Age-related macular degeneration (AMD) is an eye disease causing damage to the macular region of the retina where most of the photoreceptors responsible for central visual acuity are located. MicroRNAs (miRNAs) are small single-stranded non-coding RNA molecules that negatively regulate genes by silent post-transcriptional gene expressions. Previous studies have shown that changes in specific miRNAs are involved in the pathogenesis of eye diseases, including AMD. Altered expressions of miRNAs are related to disturbances of regulating oxidative stress, inflammation, angiogenesis, apoptosis and phagocytosis, which are known factors in the pathogenesis of AMD. Moreover, dysregulation of miRNA is involved in drusen formation. Thus, miRNAs may be used as potential molecular biomarkers for the disease and, furthermore, tailoring therapeutics to particular disturbances in miRNAs may, in the future, offer hope to prevent irreversible vision loss. In this review, we clarify the current state of knowledge about the influence of miRNA on the pathogenesis, diagnosis and treatment of AMD. Our study material consisted of publications, which were found in PubMed, Google Scholar and Embase databases using "Age-related macular degeneration", "miRNA", "AMD biomarkers", "miRNA therapeutics" and "AMD pathogenesis" as keywords. Paper search was limited to articles published from 2011 to date. In the section "Retinal, circulating and vitreous body miRNAs found in human studies", we limited the search to studies with patients published in 2016-2021