Supporting research and development in ambulance services: research for better healthcare in prehospital settings

Background This paper discusses recent developments in research support for ambulance trusts in England and Wales and how this could be designed to lead to better implementation, collaboration in and initiation of high-quality research to support a truly evidence-based service. Method The National Ambulance Research Steering Group was set up in 2007 to establish the strategic direction for involvement of regional ambulance services in developing relevant and well-designed research for improving the quality of services to patients. Results Ambulance services have been working together and with academic partners to implement research and to participate, collaborate and lead the design of research that is relevant for patients and ambulance services. Conclusion New structures to support the strategic development of ambulance and prehospital research will help address gaps in the evidence for health interventions and service delivery in prehospital and ambulance care and ensure that ambulance services can increase their capacity and capability for high-quality research

Gas of self-avoiding loops on the brickwork lattice

An exact calculation of the phase diagram for a loop gas model on the brickwork lattice is presented. The model includes a bending energy. In the dense limit, where all the lattice sites are occupied, a phase transition occuring at an asymmetric Lifshitz tricritical point is observed as the temperature associated with the bending energy is varied. Various critical exponents are calculated. At lower densities, two lines of transitions (in the Ising universality class) are observed, terminated by a tricritical point, where there is a change in the modulation of the correlation function. To each tricritical point an associated disorder line is found.Comment: 19 pages, 6 figures. to appear in J. Phys. A : Math. & Ge

A cohort study of duplex Doppler examinations of the carotid artery in primary open angle glaucoma

Objectives To explore the possibility of pathological change in the common carotid artery at the bifurcation and in the internal carotid artery beyond the bifurcation which could contribute to a reduced diastolic pressure as observed in primary open angle glaucoma. Design Duplex ultrasonic examinations of carotid bifurcations were conducted on 80 patients. Carotid artery defects were allocated into three types: no demonstrable flow defects, internal carotid artery abnormalities and disease in the carotid bulb. Setting Bristol Royal Infirmary Vascular Laboratory. Participants Eighty patients (mean age 69.6 years) providing a total of 160 sides to the analysis. Main outcome measures An estimated central retinal artery pressure, intraocular pressure and field loss were recorded for each side measured. Results Doppler investigations revealed significant levels of pathological change in the internal carotid distinct from changes at the carotid bulb. The disease revealed in the internal carotid artery was significantly associated with intraocular pressure (p = 0.032), with an effect small to medium in magnitude. The Q2 measure, derived from mean arterial pressure and intraocular pressure, was also substantively associated with disease in the internal carotid artery. Both intraocular pressure and the Q2 measure effectively discriminated between groups, with field loss providing rather less discriminating capability. There was a strong trend towards a higher intraocular pressures and a greater visual field loss with internal carotid artery disease. Conclusions Pathological changes in the extra cranial carotid artery in primary open angle glaucoma exceed those in the arteries classified as normal. The presence of disease specifically in the internal carotid artery emphasised the need for a mechanism for the evaluation of the internal carotid apart from the carotid bulb. A basis for clarifying the presence of an ischaemic zone is proposed

Holocene-Neogene volcanism in northeastern Australia: chronology and eruption history

Quaternary and late Neogene volcanism is widespread in northeastern Australia, producing at least 397 eruptions covering more than 20,000 km2, including at least 20 flows over 50 km long. Despite this abundance of young volcanism, before this study numerous eruptions had tentative ages or were undated, and the area requires a comprehensive evaluation of eruption patterns through time. To help address these issues we applied multi-collector ARGUS-V 40Ar/39Ar geochronology to determine the age of four of the younger extensive flows: Undara (160 km long, 189 ± 4/4 ka; 2σ, with full analytical/external uncertainties), Murronga (40 km long, 153 ± 5/5 ka), Toomba (120 km long, 21 ± 3/3 ka), and Kinrara (55 km long, 7 ± 2/2 ka). Verbal traditions of the Gugu Badhun Aboriginal people contain features that may potentially describe the eruption of Kinrara. If the traditions do record this eruption, they would have been passed down for 230 ± 70 generations – a period of time exceeding the earliest written historical records. To further examine north Queensland volcanism through time we compiled a database of 337 ages, including 179 previously unpublished K-Ar and radiocarbon results. The compiled ages demonstrate that volcanic activity has occurred without major time breaks since at least 9 Ma. The greatest frequency of eruptions occurred in the last 2 Ma, with an average recurrence interval of <10–22 ka between eruptions. Activity was at times likely more frequent than these calculations indicate, as the geochronologic dataset is incomplete, with undated eruptions, and intraplate volcanism is often episodic. The duration, frequency, and youthfulness of activity indicate that north Queensland volcanism should be considered as potentially still active, and there are now two confirmed areas of Holocene volcanism in eastern Australia – one at each end of the continent. More broadly, our data provides another example of 40Ar/39Ar geochronology applied to Holocene and latest Pleistocene mafic eruptions, further demonstrating that this method has the ability to examine eruptions and hazards at the youngest volcanoes on Earth

Bioeconomy and Circular Economy Approaches Need to Enhance the Focus on Biodiversity to Achieve Sustainability

Bioeconomy and circular economy approaches are being adopted by an increasing number of international organizations, governments and companies to enhance sustainability. Concerns have been raised about the implications for biodiversity. Here, we present a review of current research on the two approaches to determine their relationship to each other and to other economic models, their impact on sustainability and their relationship with biodiversity. Bioeconomy and circular economy are both poorly defined, inconsistently implemented and inadequately measured, and neither provides a clear pathway to sustainability. Many actors promote goals around economic growth above environmental issues. Biodiversity is often addressed indirectly or inadequately. Furthermore, many traditionally disadvantaged groups, including women and indigenous people, may be neglected and rarely engage or benefit. These challenges are compounded by capacity gaps and legal and governance complexities around implementation, influenced by traditional mindsets and approaches. Countries and companies need to plan their sustainability strategies more explicitly around the biodiversity they impact. Opportunities include the relevance and timeliness of sustainable economics for delivering Sustainable Development Goals in a post-COVID world, the existence of work to be built on, and the diversity of stakeholders already engaged. We propose five main steps to ensure the sustainability of economic approaches. Ultimately, we can ensure sustainability only by starting to shift mindsets and establishing a more focused agenda for bioeconomy and circular economy that puts species, ecosystems and the wellbeing of local people at the center