Health and sustainable development

If sustainable development is to mean anything, people must be healthy enough to benefit from it and not have their lives cut off prematurely. Development without health is meaningless. But the processes which are likely to occur in a world undergoing globalisation, climate change, urbanisation, population increase and many other changes, will impact upon human health in complex ways. Some of them will benefit us, others will create new or augmented threats to survival and health, while many others will have a complex mixture of effects

DESIGN OF A PARALLEL EDUCATIONAL SATELLITE GROUND STATION

The Mobile CubeSat Command and Control (MC3) ground station network provides communications infrastructure for small satellites developed by U.S. government organizations, contractors, and educational institutions. As the network has matured, so too have the cybersecurity requirements that govern its operations. By implementing tight configuration constraints on software, hardware, and networking, ground stations are unable to utilize the equipment outside standard operations. This poses a particular problem for educational institutions that routinely involve such equipment in their curricula for hands-on instruction and research. This research effort focuses on design, implementation, and testing of a parallel ground station to MC3 that allows educational institutions the freedom to innovate and perform research. The parallel station will share the MC3 antenna, the most valuable component of the ground station, but provide a separate rack of equipment that functions as a separate ground station. This research applies directly to those institutions that are currently members of the MC3 system. Currently, the Naval Postgraduate School, the United States Coast Guard Academy, and the United States Naval Academy have expressed interest in a parallel ground station. The resulting approach benefits these educational institutions by removing barriers of development and increasing instructional impact in the ever-competitive worldwide aerospace industry.Ensign, United States NavyApproved for public release. Distribution is unlimited

Letters between Walter H. Bradley and William Kerr\u27s secretary

Letters concerning a position in the modern languages department at Utah Agricultural College

Distribution and Redistribution in Post-Industrial Democracies

This paper analyzes the processes of distribution and redistribution in post-industrial democracies. We combine a pooled time series data base on welfare state effort and its determinants assembled by Huber, Ragin, and Stephens (1997) with data on income distribution assembled in the Luxembourg Income Survey (LIS) archive. In the case of the LIS data, we re-calculate the micro-data in order to remove the distorting influence of pensioners on pre-tax, pre transfer income distribution. We examine the determinants of three dependent variables: pre-tax, pre-transfer income inequality, post- tax, post transfer income inequality and the proportional reduction in inequality from pre to post tax and transfer inequality. We hypothesized that pre-tax, pre-transfer income inequality would be determined by labor market institutions (union density, bargaining centralization), labor market conditions (unemployment), and economic structures (post-industrialism, third world imports). We hypothesized that the reduction in inequality would be determined by political configurations: directly by left government and indirectly via their effect on welfare state generosity by left government and Christian democratic government. Post tax and transfer income inequality was hypothesized to be a product of the combination of labor market variables and political variables. The results broadly confirms our hypotheses and the overall fit is very good

The Welfare State and Gender Equality

This paper examines the determinants of several indicators of economic well being of women. The feminist literature has suggested that women's well being is best measured through both the economic status of women and power relations vis-à-vis men. Barbara Hobson has proposed that the percentage of single mothers in poverty and married women's income as a proportion of both spouses' income effectively measure economic status and power relations. The dependent variables are calculated from micro data available in the Luxembourg Income Survey (LIS) archive, which now contains enough countries and time points to allow multivariate statistical analysis with a sufficiently large number of independent variables to test a broad range of hypotheses on the determinants of gender egalitarian outcomes while controlling for other possible determinants. In the case of poverty among single mothers, the LIS data also allow us to go beyond Hobson's single indicator to investigate the extent to which government action is responsible for poverty reduction. Hence, we analyze 4 dependent variables: 1) pre tax and transfer poverty rates among single mothers, 2) reductions in single mothers' poverty due to taxes and transfers, 3) post tax and transfer poverty rates among single mothers, and 4) women's wages relative to spouses' wages. In these analyses, we test feminist theories along with theories of economic structure, labor market institutions, state structure and political power

The State and Poverty Alleviation in Advanced Capitalist Democracies

We analyze the impact of the state on the incidence of poverty in the working-age population of 14 advanced capitalist democracies between 1970 and 1997 using an unbalanced panel design. We utilize poverty measures based on micro-level data from the Luxembourg Income Study in conjunction with pooled time series data from the Huber, Ragin and Stephens (1997) database. We argue that economic factors including de-industrialization and unemployment largely explain pre-tax, pre-transfer poverty rates of the working age population in advanced capitalist states. These rates, however, are theoretical as advanced democracies redistribute resources through taxes and transfers. We show that the extent of redistribution (measured as poverty reduction via taxes and transfers) is explained directly by welfare state generosity as well as constitutional structure (number of veto points) and the strength of the left, both in unions and in government

Impact of obesity on IL-12 family gene expression in insulin responsive tissues

Mounting evidence has established a role for chronic inflammation in the development of obesity-induced insulin resistance, as genetic ablation of pro-inflammatory cytokines and chemokines elevated in obesity improves insulin signaling in vitro and in vivo. Recent evidence further highlights interleukin (IL)-12 family cytokines as prospective inflammatory mediators linking obesity to insulin resistance. In this study, we present empirical evidence demonstrating that IL-12 family related genes are expressed and regulated in insulin-responsive tissues under conditions of obesity. First, we report that respective mRNAs for each of the known members of this cytokine family are expressed within detectable ranges in WAT, skeletal muscle, liver and heart. Second, we show that these cytokines and their cognate receptors are divergently regulated with genetic obesity in a tissue-specific manner. Third, we demonstrate that select IL-12 family cytokines are regulated in WAT in a manner that is dependent on the developmental stage of obesity as well as the inflammatory progression associated with obesity. Fourth, we report that respective mRNAs for IL-12 cytokines and receptors are also expressed and divergently regulated in cultured adipocytes under conditions of inflammatory stress. To our knowledge, this report is the first study to systemically evaluated mRNA expression of all IL-12 family cytokines and receptors in any tissue under conditions of obesity highlighting select family members as potential mediators linking excess nutrient intake to metabolic diseases such as insulin resistance, diabetes and heart disease. © 2012 Elsevier B.V

Mitogen-Dependent Regulation of DUSP1 Governs ERK and p38 Signaling During Early 3T3-L1 Adipocyte Differentiation

© 2015 Wiley Periodicals, Inc. Knowledge concerning mechanisms that control proliferation and differentiation of preadipocytes is essential to our understanding of adipocyte hyperplasia and the development of obesity. Evidence has shown that temporal regulation of mitogen-activated protein kinase (MAPK) phosphorylation and dephosphorylation is critical for coupling extracellular stimuli to cellular growth and differentiation. Using differentiating 3T3-L1 preadipocytes as a model of adipocyte hyperplasia, we examined a role for dual-specificity phosphatase 1 (DUSP1) on the timely modulation of MAPK signaling during states of growth arrest, proliferation, and differentiation. Using real-time reverse transcription PCR (qRT-PCR), we report that DUSP1 is induced during early preadipocyte proliferation concomitant with ERK and p38 dephosphorylation. As deactivation of ERK and p38 is essential for the progression of adipocyte differentiation, we further showed that de novo mRNA synthesis was required for ERK and p38 dephosphorylation, suggesting a role for inducible phosphatases in regulating MAPK signaling. Pharmacological and genetic inhibition of DUSP1 markedly increased ERK and p38 phosphorylation during early adipocyte differentiation. Based on these findings, we postulated that loss of DUSP1 would block adipocyte hyperplasia. However, genetic loss of DUSP1 was not sufficient to prevent preadipocyte proliferation or differentiation, suggesting a role for other phosphatases in the regulation of adipogenesis. In support of this, qRT-PCR identified several MAPK-specific DUSPs induced during early (DUSP2, -4, -5, & -6), mid (DUSP4 & -16) and late (DUSP9) stages of adipocyte differentiation. Collectively, these data suggest an important role for DUSPs in regulating MAPK dephosphorylation, with an emphasis on DUSP1, during early adipogenesis