A reactive assimilation model for regional-scale cordierite-bearing granitoids: geochemical evidence from the Late Variscan granites of the Central Iberian Zone, Spain

Regional scale biotite and cordierite-bearing granites (s.l.) in the Variscan of the Central Iberian Zone (CIZ) are spatially closely associated with cordierite-rich nebulites and cordierite-bearing two-mica granites, and with cordierite-rich high grade hornfelses and cordieritites (>60% cordierite) that are relatively common in the aureoles of these granites. Building on published field evidence, petrological data are presented which, combined with new chemical and isotopic (Sr-Nd) modelling, indicate that the cordierite-bearing granites cannot be derived by simple anatexis of regional sedimenatry protoliths; but the data are consistent with a process of reactive assimilation that involves the interaction of biotite granite magma with high-grade host rocks ranging from cordierite nebulites to andalusite-bearing cordieritites. The contribution of the postulated cordierite-rich contaminants to the diversity of cordierite granite compositions is modelled using the compositions of regional Lower Cambrian-Upper Neoproterozoic metasedimentary rocks that are generally chemically mature (CaO very rarely exceeds 1.4%). These rocks include specific horizons in which extreme chemical alteration is attributable to sediment reworking during eustatic falls in sea level. Such compositions may account for the presence of the high concentrations in Al that later produced cordieritites. Fractional crystallisation is also important, particularly in generating the more evolved cordierite granite and cordierite biotite muscovite granite compositions. Although assimilation in situ is normally regarded as a minor contributor volumetrically to evolving plutons, in this instance the emplacement of large volumes of granite magma into a high-T-low-P environment significantly increased the potential for reactive assimilation

Mobile phone applications use while driving in Ukraine: Self-reported frequencies and psychosocial factors underpinning this risky behaviour

© 2021 Hill et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Despite the fact that mobile phones have been transformed over the last decade into information and communication hubs that are fundamental to modern life, there is little information on how this has impacted on mobile phone use while driving. The present study was conducted in Ukraine, where this risky behaviour remains a common driving practice, despite legislative bans. A total of 220 (male = 82%; mean age = 35.53; SD = 10.54) drivers completed an online survey assessing frequency of engaging in a range of mobile phone applications while driving. Four variables of the theory of planned behaviour (general attitude and intention towards phone use while driving, social norms towards mobile phone use, perceived behavioural control, the specific beliefs about being able to engage in distracting activities and drive safely), and type A behaviour pattern were also collected. The results showed that, during the last year, 65% of drivers had read a text message and 49% had written a text using mobile phone applications. Likewise, a substantial proportion of the sample reported using social media while driving, by checking (34%), sending or typing a post (25%) on social network applications. Hierarchical stepwise regressions showed that a positive attitude towards mobile phone use while driving and beliefs about being able to drive safely and write or read a text message were significantly associated with the mobile phone applications use while driving. No associations were found between the type A behaviour pattern and mobile phone applications use.Peer reviewe

Selective Expression of Immune-Associated Surface Antigens by Keratinocytes in Irritant Contact Dermatitis

The expression of three immunoregulatory surface antigens by epidermal keratinocytes was studied in irritant contact dermatitis (lCD), in order to assess whether keratinocytes have a modulatory role in the pathogenesis of this disorder. Biopsies were taken from 48-h patch test reactions to six structurally unrelated irritants, and frozen sections immunolabeled with monoclonal antibodies to the major histocompatibility complex class II antigen, HLA-DR, intercellular adhesion molecule-i (ICAM-1), and the 88-Kd glycoprotein CD36 (OKM5), as well as to the CD3 (T cells) and CD11a (lymphocyte function associated antigen-1, LFA-1) antigens. We found that there was very limited expression of HLA- DR by keratinocytes, with no correlation between the extent of HLA-DR positivity and the degree of T cell infiltration into the epidermis and dermis, suggesting that interferon gamma may not be a significant mediator of lCD at 48h. In contrast, keratinocytes showed extensive upregulation of ICAM-1, with an excellent spatial association between ICAM-1 expression and LFA-1 positive leucocytes in the epidermis. This indicates that keratinocyte JCAM-1 induction is not restricted to diseases in which antigen presentation is pivotal, but that it has a generalized role in cutaneous inflammatory reactions, promoting the infiltration of leucocytes into the epidermis. Immunolabeling with OKM5 revealed that CD36 is present to a variable degree on keratinocytes in normal skin. Differential changes in the pattern of keratinocyte expression occurred between irritants, in a manner that suggested that the CD36 antigen does not act as an adhesion molecule in lCD, but rather that its expression is related to the proliferative state of the epidermis. The results of this study demonstrate that immune-associated antigens are selectively expressed on the surface of keratinocytes in 48-h ICD biopsies, implying that these cells play an important regulatory role in the development of the inflammatory response to irritant chemicals

Is There Really a de Sitter/CFT Duality

In this paper a de Sitter Space version of Black Hole Complementarity is formulated which states that an observer in de Sitter Space describes the surrounding space as a sealed finite temperature cavity bounded by a horizon which allows no loss of information. We then discuss the implications of this for the existence of boundary correlators in the hypothesized dS/cft correspondence. We find that dS complementarity precludes the existence of the appropriate limits. We find that the limits exist only in approximations in which the entropy of the de Sitter Space is infinite. The reason that the correlators exist in quantum field theory in the de Sitter Space background is traced to the fact that horizon entropy is infinite in QFT.Comment: 12 Figures, STIAS Workshop on Quantum Gravit

A vortex description of the first-order phase transition in type-I superconductors

Using both analytical arguments and detailed numerical evidence we show that the first order transition in the type-I 2D Abelian Higgs model can be understood in terms of the statistical mechanics of vortices, which behave in this regime as an ensemble of attractive particles. The well-known instabilities of such ensembles are shown to be connected to the process of phase nucleation. By characterizing the equation of state for the vortex ensemble we show that the temperature for the onset of a clustering instability is in qualitative agreement with the critical temperature. Below this point the vortex ensemble collapses to a single cluster, which is a non-extensive phase, and disappears in the absence of net topological charge. The vortex description provides a detailed mechanism for the first order transition, which applies at arbitrarily weak type-I and is gauge invariant unlike the usual field-theoretic considerations, which rely on asymptotically large gauge coupling.Comment: 4 pages, 6 figures, uses RevTex. Additional references added, some small corrections to the tex

The composition of the zebrafish intestinal microbial community varies across development

The assembly of resident microbial communities is an important event in animal development; however, the extent to which this process mirrors the developmental programs of host tissues is unknown. Here we surveyed the intestinal bacteria at key developmental time points in a sibling group of 135 individuals of a model vertebrate, the zebrafish (Danio rerio). Our survey revealed stage-specific signatures in the intestinal microbiota and extensive interindividual variation, even within the same developmental stage. Microbial community shifts were apparent during periods of constant diet and environmental conditions, as well as in concert with dietary and environmental change. Interindividual variation in the intestinal microbiota increased with age, as did the difference between the intestinal microbiota and microbes in the surrounding environment. Our results indicate that zebrafish intestinal microbiota assemble into distinct communities throughout development, and that these communities are increasingly different from the surrounding environment and from one another

Contribution of neutral processes to the assembly of gut microbial communities in the zebrafish over host development

Despite their importance to host health and development, the communities of microorganisms associated with humans and other animals are characterized by a large degree of unexplained variation across individual hosts. The processes that drive such inter-individual variation are not well understood. To address this, we surveyed the microbial communities associated with the intestine of the zebrafish, Danio rerio, over developmental time. We compared our observations of community composition and distribution across hosts with that predicted by a neutral assembly model, which assumes that community assembly is driven solely by chance and dispersal. We found that as hosts develop from larvae to adults, the fit of the model to observed microbial distributions decreases, suggesting that the relative importance of non-neutral processes, such as microbe-microbe interactions, active dispersal, or selection by the host, increases as hosts mature. We also observed that taxa which depart in their distributions from the neutral prediction form ecologically distinct sub-groups, which are phylogenetically clustered with respect to the full metacommunity. These results demonstrate that neutral processes are sufficient to generate substantial variation in microbiota composition across individual hosts, and suggest that potentially unique or important taxa may be identified by their divergence from neutral distributions

De Sitter Holography with a Finite Number of States

We investigate the possibility that, in a combined theory of quantum mechanics and gravity, de Sitter space is described by finitely many states. The notion of observer complementarity, which states that each observer has complete but complementary information, implies that, for a single observer, the complete Hilbert space describes one side of the horizon. Observer complementarity is implemented by identifying antipodal states with outgoing states. The de Sitter group acts on S-matrix elements. Despite the fact that the de Sitter group has no nontrivial finite-dimensional unitary representations, we show that it is possible to construct an S-matrix that is finite-dimensional, unitary, and de Sitter-invariant. We present a class of examples that realize this idea holographically in terms of spinor fields on the boundary sphere. The finite dimensionality is due to Fermi statistics and an `exclusion principle' that truncates the orthonormal basis in which the spinor fields can be expanded.Comment: 23 pages, 1 eps figure, LaTe

Pan-European early switch/early discharge opportunities exist for hospitalised patients with methicillin-resistant <em>Staphylococcus</em> <em>aureus</em> complicated skin and soft-tissue infections

AbstractThe objective of this study was to document pan-European real-world treatment patterns and healthcare resource use and estimate opportunities for early switch (ES) from intravenous (IV) to oral antibiotics and early discharge (ED) in hospitalized patients with methicillin-resistant Staphylococcus aureus (MRSA) complicated skin and soft tissue infections (cSSTIs). This retrospective observational medical chart review study enrolled 342 physicians across 12 European countries who collected data from 1542 patients with documented MRSA cSSTI who were hospitalized (July 2010 to June 2011) and discharged alive (by July 2011). Data included clinical characteristics and outcomes, hospital length of stay (LOS), MRSA-targeted IV and oral antibiotic use, and ES and ED eligibility according to literature-based and expert-validated criteria. The most frequent initial MRSA-active antibiotics were vancomycin (50.2%), linezolid (15.1%), clindamycin (10.8%), and teicoplanin (10.4%). Patients discharged with MRSA-active antibiotics (n = 480) were most frequently prescribed linezolid (42.1%) and clindamycin (19.8%). IV treatment duration (9.3 ± 6.5 vs. 14.6 ± 9.9 days; p <0.001) and hospital LOS (19.1 ± 12.9 vs. 21.0 ± 18.2 days; p 0.162) tended to be shorter for patients switched from IV to oral treatment than for patients who received IV treatment only. Of the patients, 33.6% met ES criteria and could have discontinued IV treatment 6.0 ± 5.5 days earlier, and 37.9% met ED criteria and could have been discharged 6.2 ± 8.2 days earlier. More than one-third of European patients hospitalized for MRSA cSSTI could be eligible for ES and ED, resulting in substantial reductions in IV days and bed-days, with potential savings of €2000 per ED-eligible patient