Copper-Catalyzed Aminooxygenation of <i>N</i>‑Allylamidines with PhI(OAc)₂

A Cu-catalyzed aminoacetoxylation of <i>N</i>-alkenylamidines has been achieved using PhI(OAc)₂ as an oxygen source for synthesis of 4-acetoxymethyl-4,5-dihydroimidazoles, which could be further converted into 2,3-diaminopropanol derivatives using AlH₃ as a reductant

Copper-Catalyzed Aliphatic C–H Amination with an Amidine Moiety

A method for amination of aliphatic C–H bonds of <i>N</i>-alkylamidines is described that utilizes Cu(OAc)₂ as the catalyst in the presence of PhI(OAc)₂ and K₃PO₄. The resulting products, dihydroimidazoles and tetrahydropyrimidines, could be converted into the corresponding diamines by hydride reduction

Copper-Catalyzed Aerobic Intramolecular Carbo- and Amino-Oxygenation of Alkynes for Synthesis of Azaheterocycles

A synthetic method of highly substituted quinolines has been developed from <i>N</i>-(2-alkynylaryl)enamine carboxylates under Cu-catalyzed aerobic conditions via intramolecular carbo-oxygenation of alkynes. This strategy was further applied for <i>N</i>-alkynylamidines for amino-oxygenation of alkynes, leading to imidazole and quinazoline derivatives

Copper-Catalyzed Aerobic Intramolecular Carbo- and Amino-Oxygenation of Alkynes for Synthesis of Azaheterocycles

A synthetic method of highly substituted quinolines has been developed from <i>N</i>-(2-alkynylaryl)enamine carboxylates under Cu-catalyzed aerobic conditions via intramolecular carbo-oxygenation of alkynes. This strategy was further applied for <i>N</i>-alkynylamidines for amino-oxygenation of alkynes, leading to imidazole and quinazoline derivatives