Copper-Catalyzed Aliphatic C–H Amination with an Amidine Moiety

Abstract

A method for amination of aliphatic C–H bonds of <i>N</i>-alkylamidines is described that utilizes Cu(OAc)₂ as the catalyst in the presence of PhI(OAc)₂ and K₃PO₄. The resulting products, dihydroimidazoles and tetrahydropyrimidines, could be converted into the corresponding diamines by hydride reduction