Ambiguity and ambivalence: organizational change in government departments

The way in which workers and managers interpret change at work has been an important focus of interest for researchers. This interpretation may find them assimilating change as they listen to accounts from other workers experienced in the outcomes of such events. On the other hand, there may be a divergence among workers concerning the value and meaning to be ascribed to the change events. If this is the case, a culture of ambiguity may be said to exist, where the nature, degree and value of the cultural change are highly contested and remarkably unclear (McLoughlin et al;., 2005). Following Piderit (2000), this paper suggests this may explain the disparity between an individual’s expectancy of change and their response to it, and also that, individuals’ ambivalence may influence whether they accept change, adapt to it, or reject it out-of-hand, . We show how different dimensions of ambivalence in different individuals can lead not only to different responses to imposed change at work, but can also account for individuals coming to terms with the demands of change

Antibiotic Sensitivity of Staph. aureus

Undergraduate Experimental Basi

New monetarist economics: methods

This essay articulates the principles and practices of New Monetarism, the authors' label for a recent body of work on money, banking, payments, and asset markets. They first discuss methodological issues distinguishing their approach from others: New Monetarism has something in common with Old Monetarism, but there are also important differences; it has little in common with Keynesianism. They describe the principles of these schools and contrast them with their approach. To show how it works in practice, they build a benchmark New Monetarist model and use it to study several issues, including the cost of inflation, liquidity, and asset trading. They also develop a new model of banking.Monetary policy

Paramyxovirus V proteins interact with the RNA helicase LGP2 to inhibit RIG-I-dependent interferon induction

This work was supported by the Wellcome Trust (grant AL087751/B)RIG-I and mda-5 are activated by viral RNA and stimulate type I interferon production. Laboratory of genetics and physiology 2 (LGP2) shares homology with RIG-I and mda-5 but lacks the CARD domains required for signaling. The V proteins of paramyxoviruses limit interferon induction by binding mda-5 and preventing its activation; however, they do not bind RIG-I and have not been considered inhibitors of RIG-I signaling. Here we uncover a novel mechanism of RIG-I inhibition in which the V protein of parainfluenzavirus type 5 (PIV5; formerly known as simian virus type 5 [SV5]) interacts with LGP2 and cooperatively inhibits induction by RIG-I ligands. A complex between RIG-I and LGP2 is observed in the presence of PIV5-V, and we propose that this complex is refractory to activation by RIG-I ligands. The V proteins from other paramyxoviruses also bind LGP2 and demonstrate LGP2-dependent inhibition of RIG-I signaling. This is significant, because it demonstrates a general mechanism for the targeting of the RIG-I pathway by paramyxoviruses.Publisher PDFPeer reviewe

New Monetarist Economics: models

The purpose of this paper is to discuss some of the models used in New Monetarist Economics, which is our label for a body of recent work on money, banking, payments systems, asset markets, and related topics. A key principle in New Monetarism is that solid microfoundations are critical for understanding monetary issues. We survey recent papers on monetary theory, showing how they build on common foundations. We then lay out a tractable benchmark version of the model that allows us to address a variety of issues. We use it to analyze some classic economic topics, like the welfare effects of inflation, the relationship between money and capital accumulation, and the Phillips curve. We also extend the benchmark model in new ways, and show how it can be used to generate new insights in the study of payments, banking, and asset markets.Money ; Monetary policy

Circular 101

This study was made possible by the financial support of the Alaska Science and Technology Foundation

The release of a captive-raised female African Elephant <em>(Loxodonta africana</em>) in the Okavango Delta, Botswana

Wild female elephants live in close-knit matrilineal groups and housing captive elephants in artificial social groupings can cause significant welfare issues for individuals not accepted by other group members. We document the release of a captive-raised female elephant used in the safari industry because of welfare and management problems. She was fitted with a satellite collar, and spatial and behavioural data were collected over a 17-month period to quantify her interactions with the wild population. She was then monitored infrequently for a further five-and-a-half years. We observed few signs of aggression towards her from the wild elephants with which she socialized. She used an area of comparable size to wild female elephants, and this continued to increase as she explored new areas. Although she did not fully integrate into a wild herd, she had three calves of her own, and formed a social unit with another female and her calf that were later released from the same captive herd. We recommend that release to the wild be considered as a management option for other captive female elephants

Journey in Confusion

How dark this place is... But I know my way. Yes, I see, that light ahead Is where I want to go. Yes, I am sure... Yet the light fades..