3,591 research outputs found
Prediction of the Spectrum of a Digital Delta–Sigma Modulator Followed by a Polynomial Nonlinearity
This paper presents a mathematical analysis of the power spectral density of the output of a nonlinear block driven by a digital delta-sigma modulator. The nonlinearity is a memoryless third-order polynomial with real coefficients. The analysis yields expressions that predict the noise floor caused by the nonlinearity when the input is constant
An Introduction to G Methods
Robins' generalized methods (g methods) provide consistent estimates of contrasts (e.g. differences, ratios) of potential outcomes under a less restrictive set of identification conditions than do standard regression methods (e.g. linear, logistic, Cox regression). Uptake of g methods by epidemiologists has been hampered by limitations in understanding both conceptual and technical details. We present a simple worked example that illustrates basic concepts, while minimizing technical complications
Circumbinary disk evolution in the presence of an outer companion star
We consider a hierarchical triple system consisting of an inner eccentric
binary with an outer companion. A highly misaligned circumbinary disk around
the inner binary is subject to two competing effects: (i) nodal precession
about the inner binary eccentricity vector that leads to an increase in
misalignment (polar alignment) and (ii) Kozai-Lidov (KL) oscillations of
eccentricity and inclination driven by the outer companion that leads to a
reduction in the misalignment. The outcome depends upon the ratio of the
timescales of these effects. If the inner binary torque dominates, then the
disk aligns to a polar orientation. If the outer companion torque dominates,
then the disk undergoes KL oscillations. In that case, the highly eccentric and
misaligned disk is disrupted and accreted by the inner binary, while some mass
is transferred to the outer companion. However, when the torques are similar,
the outer parts of the circumbinary disk can undergo large eccentricity
oscillations while the inclination remains close to the polar orientation. The
range of initial disk inclinations that evolve to a polar orientation is
smaller in the presence of the outer companion. Disk breaking is also more
likely, at least temporarily, during the polar alignment process. The stellar
orbits in HD 98800 have parameters such that polar alignment of the
circumbinary disk is expected. In the absence of the gas, solid particles are
unstable at much smaller radii than the gas disk inner tidal truncation radius
because KL driven eccentricity leads to close encounters with the binary.Comment: Accepted for publication in ApJ
A New Limit on the Antiproton Lifetime
Measurements of the cosmic ray pbar/p ratio are compared to predictions from
an inhomogeneous disk-diffusion model of pbar production and propagation within
the Galaxy, combined with a calculation of the modulation of the interstellar
cosmic ray spectra as the particles propagate through the heliosphere to the
Earth. The predictions agree with the observed pbar/p spectrum. Adding a finite
pbar lifetime to the model, we obtain the limit tau_pbar > 0.8 Myr (90 % C.L.).Comment: 13 pages, 3 encapsulated Postscript figures, uses AASTeX; accepted by
Astrophysical Journal; minor change
The electrophilic fluorination of enol esters using SelectFluor : a polar two-electron process
The reaction of enol esters with SelectFluor is facile and leads to the corresponding α-fluoroketones under mild conditions and, as a result, this route is commonly employed for the synthesis of medicinally important compounds such as fluorinated steroids. However, despite the use of this methodology in synthesis, the mechanism of this reaction and the influence of structure on reactivity are unclear. We present a rigorous mechanistic study of the fluorination of these substrates, informed primarily by detailed and robust kinetic experiments. The results of this study implicate a polar two-electron process via an oxygen-stabilised carbenium species, rather than a single-electron process involving radical intermediates. The structure/reactivity relationships revealed here will assist synthetic chemists in deploying this type of methodology in the syntheses of α-fluoroketone
Impact of Canadian tobacco packaging policy on quitline reach and reach equity
AbstractObjectiveTo examine the impact of the new Canadian tobacco package warning labels with a quitline toll-free phone number for seven provincial quitlines, focusing on treatment reach and reach equity in selected vulnerable groups.MethodsA quasi-experimental design assessed changes in new incoming caller characteristics, treatment reach for selected vulnerable sub-populations and the extent to which this reach is equitable, before and after the introduction of the labels in June, 2012. Administrative call data on smokers were collected at intake. Pre- and post-label treatment reach and reach equity differences were analysed by comparing the natural logarithms of the reach and reach equity statistics.ResultsDuring the six months following the introduction of the new warning labels, 86.4% of incoming new callers indicated seeing the quitline number on the labels. Treatment reach for the six-month period significantly improved compared to the same six-month period the year before from .042% to .114% (p<.0001) and reach equity significantly improved for young males (p<.0001) and those with high school education or less (p=.004).ConclusionsThe introduction of the new tobacco warning labels with a quitline toll-free number in Canada was associated with an increase in treatment reach. The toll-free number on tobacco warning labels aided in reducing tobacco related inequalities, such as improved reach equity for young males and those with high school or less education
Cardiometabolic Risk Factors in Pregnancy and Implications for Long-Term Health: Identifying the Research Priorities for Low-Resource Settings.
Cardiometabolic disorders (CMDs), including ischemic heart disease, stroke and type 2 diabetes are the leading causes of mortality and morbidity in women worldwide. The burden of CMDs falls disproportionately on low and middle-income countries (LMICs), placing substantial demands on already pressured health systems. Cardiometabolic disorders may present up to a decade earlier in some LMIC settings, and are associated with high-case fatality rates. Early identification and ongoing postpartum follow-up of women with pregnancy complications such as hypertensive disorders of pregnancy (HDPs), and gestational diabetes mellitus (GDM) may offer opportunities for prevention, or help delay onset of CMDs. This mini-review paper presents an overview of the key challenges faced in the early identification, referral and management of pregnant women at increased risk of CMDs, in low-resource settings worldwide. Evidence-based strategies, including novel diagnostics, technology and innovations for early detection, screening and management for pregnant women at high-risk of CMDs are presented. The review highlights the key research priorities for addressing cardiometabolic risk in pregnancy in low-resource settings
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