'Just about coping': precarity and resilience among applied theatre and community arts workers in Northern Ireland

In March 2015, the Arts Council of Northern Ireland (ACNI) cut grant funding to some arts organisations by 40-100%, in order to manage an 11% reduction from the Northern Ireland Executive (NIE) in its 2015/16 Budget (ACNI, 2015). This was despite a high-profile ‘13p for the arts’ ACNI campaign, which had lobbied the NIE to preserve existing levels of arts funding (estimated at 13p per capita per week), already significantly lower than in other parts of the UK (‘far less than the 32 pence per week spent in Wales’, Litvack, 2014, online). Alongside cuts to spending on Social Development, Health and Education, and a reduction in European Union Peace funding, these have reduced the financial support available to applied theatre and community arts practitioners in Northern Ireland, despite such initiatives as the 2013 UK City of Culture programme. In these increasingly precarious conditions, how can community-based artists survive

An Evaluation of the Early Pharmacodynamic Response After Simultaneous Initiation of Warfarin and Amiodarone

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97172/1/0091270009351885.pd

Cell Model System for Glucocorticoid-Induced Osteoporosis

Dexamethasone, a corticosteroid that inhibits inflammation, is commonly used for the treatment of arthritis. However, glucocorticoid-induced osteoporosis is a side effect that commonly occurs after dexamethasone treatment. One of the mechanisms by which glucocorticoids are thought to suppress bone formation is through their effect on the wnt/ ß-catenin signaling pathway. The wnt/ ß-catenin pathway is essential in the formation of new osteoblasts and the prevention of osteoblast apoptosis. However, treatment with dexamethasone is thought to destabilize and inhibit nuclear translocation of ß-catenin, decreasing the survival of osteoblasts. By using precursor mouse osteoblast MC3T3 cells, we will analyze antisense morpholino oligonucleotide targeted to Col11a1 as a potential treatment to reverse or block the detrimental effects of dexamethasone on the wnt signaling pathway. MC3T3 cells will be exposed to different treatments in vitro, then aspects of the cell cycle will be analyzed by markers of apoptosis, specific signaling pathways, and cell proliferation rates. While the data obtained in this experiment is relevant to human cell functioning, future research with human cells will strengthen this line of investigation further and establish greater relevance to human health

Implicit and Explicit Attitudes Towards Mental Health Treatment

The present study assessed implicit and explicit attitudes toward mental health treatment, and whether the different attitude assessments were related to treatment-seeking. Undergraduate students (N=192) completed three Implicit Association Tests (IAT), which were computer-based reaction time tasks where participants responded to terms for mental health and medical treatments that were paired with the attributes good versus bad, effective versus ineffective, and honoring versus humiliating. Survey items assessed explicit ratings of mental health treatment and medical treatment on these attributes, as well as more general attitudes toward mental health treatment. The IAT results revealed a significant negative implicit bias toward mental health treatment as being less effective, good, and honoring than medical treatment. Explicit survey measures also showed more negative responses toward mental health treatment. Some correspondence was also obtained between the implicit biases reflected by the IAT and the explicit biases shown on the self-report survey. Finally, students who had sought mental health treatment had more positive explicit attitudes toward mental health treatment than those who had not sought treatment, but no differences were obtained on the implicit attitude measures. The current study helps to progress research working to reduce stigma towards mental health treatment and increase treatment-seeking behaviors

Intellectual Disability Related to De Novo Germline Loss of the Distal End of the P-Arm of Chromosome 17: A Case Report

Hypothesis/Purpose: In this report we present a case of a 20-year-old female with congenital intellectual disability, stunted growth, and hypothyroidism. Competitive genetic hybridization (CHG) revealed a loss of 17p13.3, and the deletion was not present in either parent. This deletion has not previously been characterized, but mutations on the p-arm of chromosome 17 are responsible for Miller-Dieker Syndrome and Isolated Lissencephaly Sequence, both of which share symptoms in common with the patient. Methods: Peripheral mononuclear cells (PBMCs) were used for karyotyping and competitive genetic hybridization (CHG). Bioinformatic analysis was carried out using the Genome Data Viewer (ncbi.nlm.nih.gov/genome/gdv). Results: Karyotype was found to be normal, but CGH revealed a deletion of the tail end of the p-arm of chromosome 17, 17p13.3. At least 134 genes are present in this genomic location, and 35 of them are uncharacterized. Both Miller-Dieker Syndrome (MDS) and Isolated Lissencephaly Sequence (ILS) are characterized by a smooth cerebral cortex and intellectual disability, but the patient’s symptoms more closely mirror MDS because muscle tone was normal. The patient was significantly shorter than peers, but growth hormone therapy over the course of several years allowed the patient to reach a normal height, albeit shorter than her siblings and parents. The list of genes deleted will be investigated to determine if a single gene is likely responsible for the phenotype. Conclusions: Here we present a patient with intellectual disability and a previously uncharacterized deletion on chromosome 17. Similar, though not identical conditions have been previously reported, but not well characterized indicating that the present patient could possibly have one of these conditions. Further directions include investigation of the deleted genes to determine a probable cause for the symptoms exhibited

The Grizzly, October 29, 1997

Pennsylvania German Art Featured at Berman Art Museum • Pfahler Workers Dismissed • New Chaplain Introduced to Community • Commonwealth Brawl Raises Student Concern • Opinion: Award Winning My Ass; A Sweet Suite; Kudos to the College; Hail to the Queen; Leaving Home for Homecoming • Ghost Stories • Bears to Clash with Muhlenberg Mules • Men\u27s B-ball Gearing Up • Player Profiles: Lieberman, Steigerwalt Lead by Example; Mahoney a Constant Force for Young Women\u27s Teamhttps://digitalcommons.ursinus.edu/grizzlynews/1408/thumbnail.jp

Exploring Glucose Dysregulation in Migraine: Insights from Continuous Glucose Monitoring

Despite being associated with hypoglycemia for nearly a century, a definitive relationship between migraines and glucose dysregulation remains elusive. Accumulating evidence suggests that migraines are in part due to a metabolic mismatch between cerebral demand and available energy. Research analyzing plasma glucose levels and migraine activity may further elucidate this interface between metabolic dysregulation and migraine pathophysiology and may potentially open avenues for therapeutic interventions targeting holistic metabolism for migraine management

The Lantern Vol. 55, No. 2, Spring 1989

• Sitting On a Summer Bench • A Perfect Daughter I Could Never Be • Roots And Wings • Sensai • The Last Three Weeks of August • Grown Up • What Size? • Hidden Colors • Victims • I Listen for Your Voice • Thoughts • In Remembrance of Grandpa • Jesus Christ, Terry • Penance • The Guys Are Driving High • You and Me and Big Ginko • The Good Ole Days of Seventh Grade • Cycles • Leather Upholstery • Chicago Kris in Cairo • Lemonade and Medicine • My Last 7:15 Communionhttps://digitalcommons.ursinus.edu/lantern/1134/thumbnail.jp