Coxsackievirus B3 Inhibits Antigen Presentation In Vivo, Exerting a Profound and Selective Effect on the MHC Class I Pathway

Many viruses encode proteins whose major function is to evade or disable the host T cell response. Nevertheless, most viruses are readily detected by host T cells, and induce relatively strong T cell responses. Herein, we employ transgenic CD4+ and CD8+ T cells as sensors to evaluate in vitro and in vivo antigen presentation by coxsackievirus B3 (CVB3), and we show that this virus almost completely inhibits antigen presentation via the MHC class I pathway, thereby evading CD8+ T cell immunity. In contrast, the presentation of CVB3-encoded MHC class II epitopes is relatively unencumbered, and CVB3 induces in vivo CD4+ T cell responses that are, by several criteria, phenotypically normal. The cells display an effector phenotype and mature into multi-functional CVB3-specific memory CD4+ T cells that expand dramatically following challenge infection and rapidly differentiate into secondary effector cells capable of secreting multiple cytokines. Our findings have implications for the efficiency of antigen cross-presentation during coxsackievirus infection

The Grizzly, August 30, 2001

Construction on Campus: Residents Return to Numerous Campus Improvement Projects • What is a Watson? • Lending a Helping Hand: Class of 2005 Volunteers at Philadelphia\u27s Cobb Creek Park • UC Students Complete Summer Research • Class of 2005 Receives Dell Laptops • Tumultuous Tuition? • Opinions: Potty Improvement?; Pet for a New Age; Mind the Dust: A Student Perspective of Construction on Campus • More Bang for Your Buck: A Comparative Report on the Prices of Condoms in Collegeville • What is There to do in Collegeville? • Francoise Gilot Exhibit in Berman Museum of Art • Art Fair Coming to Berman Museum of Art • Looking Back: The Life of an Ursinus Student in 1870 • What\u27s in a Name? • Drug-Testing for College Athletes • New Fitness Area Not Quite Ready for Students • Ursinus College Football Head Coach Peter Gallagher • Dog Days of Summer May Lead to Heat-Related Illnesseshttps://digitalcommons.ursinus.edu/grizzlynews/1491/thumbnail.jp

Restoring identity: The use of religion as a mechanism to transition between an identity of sexual offending to a non-offending identity

This study examines the unique experience of participants who during their reintegration back into the community, following a conviction for sexual offending, re-engaged with religious and spiritual communities. To explore meaning Interpretative Phenomenological Analysis (IPA) was adopted. Four in-depth interviews of men convicted for sexual crimes were undertaken and analysed. Findings indicate that through religious affiliation participants were: exposed to new prosocial networks; provided opportunities to seek forgiveness; felt a sense of belonging and affiliation; and were psychologically comforted. However, the study also found that the process of identity transition from ‘offender’ to ‘non-offender’ was not seamless or straightforward for those with an innate sexual deviancy towards children, caution is therefore advised

An analysis of patterns of distribution of buprenorphine in the United States using ARCOS, Medicaid, and Medicare databases

Opioid overdose remains a problem in the United States despite pharmacotherapies, such as buprenorphine, in the treatment of opioid use disorder. This study characterized changes in buprenorphine use. Using the Drug Enforcement Administration\u27s ARCOS, Medicaid, and Medicare claims databases, patterns in buprenorphine usage in the United States from 2018 to 2020 were analyzed by examining percentage changes in total grams distributed and changes in grams per 100 K people in year-to-year usage based on ZIP code and state levels. For ARCOS from 2018 to 2019 and 2019 to 2020, total buprenorphine distribution in grams increased by 16.2% and 12.6%, respectively. South Dakota showed the largest statewide percentage increase in both 2018–2019 (66.1%) and 2019–2020 (36.7%). From 2018 to 2019, the ZIP codes ND-577 (156.4%) and VA-222 (−82.1%) had the largest and smallest percentage changes, respectively. From 2019 to 2020, CA-932 (250.2%) and IL-603 (−36.8%) were the largest and smallest, respectively. In both 2018–2019 and 2019–2020, PA-191 had the second highest increase in grams per 100K while OH-452 was the only ZIP code to remain in the top three largest decreases in grams per 100K in both periods. Among Medicaid patients in 2018, there was a nearly 2000-fold difference in prescriptions per 100k Medicaid enrollees between Kentucky (12 075) and Nebraska (6). Among Medicare enrollees in 2018, family medicine physicians and other primary care providers were the top buprenorphine prescribers. This study not only identified overall increases in buprenorphine availability but also pronounced state-level differences. Such geographic analysis can be used to discern which public policies and regional factors impact buprenorphine access

The Grizzly, September 13, 2001

Eating in Wismer: The Crunch at Lunch • America. No Longer the Beautiful • Collegeville Police Crack Down on Ursinus Students • A New Look and New Menu at Wismer • Service Woes for Select Residents • Opinions: Wismer Bussing: A Major Problem; New Social Host Policy a Wet Blanket • International Film Festival Brings Foreign Flair to Ursinus College Campus • Review of the Restaurant La Fontana • Unconventional Fringe Fest Takes Over Philly • Like Old Movies? Then the Colonial Theater is the Place to Be • Pizza: Where\u27s the Best Buy for Your Money? • Ursinus Webpage is Getting a Makeover • Colonization of Sigma Sigma Sigma • Duncan Breaks Record as Ursinus Downs Waynesburg • Cross Country Breezes Through LBV Invitational • Two Tough Teams Equal First Two Losses for Men\u27s Soccer • UC Women\u27s Volleyball Defeats Wilkes for Third Win • Bears Fall to Montclair; Tie with Widener • UC Field Hockey Takes Slap Shot • Soccer Teams Without a Home Fieldhttps://digitalcommons.ursinus.edu/grizzlynews/1493/thumbnail.jp

The Grizzly, May 3, 2001

Xenadrine Evidence Points Towards Addictive Nature • Class of 2004 Offers Words of Wisdom to Class of 2005 • Public Radio Personality Ira Glass Hosts Lecture at Ursinus • Fountain Expected to be Completed Soon • Saying Goodbye: Grizzly Editor Signoffs • Opinions: National Missile Defense Still a Bad Idea; Greek Week Unites Local Organizations; Awards Ceremony an Enriching Experience • Stalin\u27s Daughter Steals the Stage • Annual Student Art Show Arrives at Berman • Women\u27s Lacrosse Wins CC Title; Looks Ahead to NCAA\u27s • Girls Rugby Finishes Spring Season • Tennis Teams Lose in First Round at CCC • A Weekend of CCC Playoffs and Tournaments Sees Success for Few • Final Exams Schedulehttps://digitalcommons.ursinus.edu/grizzlynews/1490/thumbnail.jp

The Grizzly, October 4, 2001

Campus-Wide Coin Drive Raises over $1,500 for Red Cross Fund • Tri Sigma Colony Established on the Ursinus Campus • Sisters of Omega Chi Organize Campus Blood Drive • Banned Book Week at UC • American Studies Major Offers Students Interdisciplinary Study • Ursinus Students Excited about Grand Opening of Local Kohls Department Store • Opinions: Exploring the Difference in Communication Between Men and Women; Student Response to Facilities in New Fitness Center; CAB Talks Back: Use it; Don\u27t Reduce it; Feeling Awkward in New Gym; Crossing and Construction Complaints on Main Street • Ghouls, Ghosts, Thrills and Chills: Area Amusement Parks Celebrate Halloween in Spooky Style • Author Lorene Cary Launches the Pew Fellow Lecture Series • Poem-palooza set to Arrive at Ursinus • Oktoberfest and Then Some • Polignano puts a new Spin on Fitness • Club Drugs: What you may not Know • Comparing Prices on Film Development • The Roaring Twenties? Perhaps not at Ursinus • Women\u27s Soccer Annihilates Washington, Shutout by Hopkins • UC Cross Country at Dickinson Invitational: Did They Just run out of Juice? • West Chester Wins Snell Cup Against UC Field Hockey, 4-1 • Volleyball Defeats Washington, but Falls to Haverford and Gettysburg • Men\u27s Soccer Takes out Washington • UC Women\u27s Rugby Kicks off Fall Seasonhttps://digitalcommons.ursinus.edu/grizzlynews/1496/thumbnail.jp

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead