Rapid adaptation of a polygenic trait after a sudden environmental shift

Although a number of studies have shown that natural and laboratory populations initially well-adapted to their environment can evolve rapidly when conditions suddenly change, the dynamics of rapid adaptation are not well understood. Here a population genetic model of polygenic selection is analyzed to describe the short-term response of a quantitative trait after a sudden shift of the phenotypic optimum. We provide explicit analytical expressions for the time scales over which the trait mean approaches the new optimum. We find that when the effect sizes are small relative to a scaled mutation rate, the genomic signatures of polygenic selection are small to moderate allele frequency changes that occur in the short-term phase in a synergistic fashion. In contrast, selective sweeps, i.e., dramatic changes in the allele frequency may occur provided the size of the effect is sufficiently large. Applications of our theoretical results to the relationship between QTL and selective sweep mapping and to tests of fast polygenic adaptation are discussed

Two-loop corrections to the ρ\rho parameter in Two-Higgs-Doublet Models

Models with two scalar doublets are among the simplest extensions of the Standard Model which fulfill the relation $\rho = 1$ at lowest order for the $\rho$ parameter as favored by experimental data for electroweak observables allowing only small deviations from unity. Such small deviations $\Delta\rho$ originate exclusively from quantum effects with special sensitivity to mass splittings between different isospin components of fermions and scalars. In this paper the dominant two-loop electroweak corrections to $\Delta\rho$ are calculated in the $CP$-conserving THDM, resulting from the top-Yukawa coupling and the self-couplings of the Higgs bosons in the gauge-less limit. The on-shell renormalization scheme is applied. With the assumption that one of the $CP$-even neutral scalars represents the scalar boson observed by the LHC experiments, with standard properties, the two-loop non-standard contributions in $\Delta\rho$ can be separated from the standard ones. These contributions are of particular interest since they increase with mass splittings between non-standard Higgs bosons and can be additionally enhanced by $\tan\beta$ and $\lambda_5$, an additional free coefficient of the Higgs potential, and can thus modify the one-loop result substantially. Numerical results are given for the dependence on the various non-standard parameters, and the influence on the calculation of electroweak precision observables is discussed.Comment: 23 pages, 17 figures, extended results section, version accepted for publication in EPJ-

Response of polygenic traits under stabilising selection and mutation when loci have unequal effects

We consider an infinitely large population under stabilising selection and mutation in which the allelic effects determining a polygenic trait vary between loci. We obtain analytical expressions for the stationary genetic variance as a function of the distribution of effects, mutation rate and selection coefficient. We also study the dynamics of the allele frequencies, focussing on short-term evolution of the phenotypic mean as it approaches the optimum after an environmental change. We find that when most effects are small, the genetic variance does not change appreciably during adaptation, and the time until the phenotypic mean reaches the optimum is short if the number of loci is large. However, when most effects are large, the change of the variance during the adaptive process cannot be neglected. In this case, the short-term dynamics may be described by that of a single locus of large effect. Our results may be used to understand polygenic selection driving rapid adaptation

Kolmogorov complexity and the Recursion Theorem

Several classes of DNR functions are characterized in terms of Kolmogorov complexity. In particular, a set of natural numbers A can wtt-compute a DNR function iff there is a nontrivial recursive lower bound on the Kolmogorov complexity of the initial segments of A. Furthermore, A can Turing compute a DNR function iff there is a nontrivial A-recursive lower bound on the Kolmogorov complexity of the initial segements of A. A is PA-complete, that is, A can compute a {0,1}-valued DNR function, iff A can compute a function F such that F(n) is a string of length n and maximal C-complexity among the strings of length n. A solves the halting problem iff A can compute a function F such that F(n) is a string of length n and maximal H-complexity among the strings of length n. Further characterizations for these classes are given. The existence of a DNR function in a Turing degree is equivalent to the failure of the Recursion Theorem for this degree; thus the provided results characterize those Turing degrees in terms of Kolmogorov complexity which do no longer permit the usage of the Recursion Theorem.Comment: Full version of paper presented at STACS 2006, Lecture Notes in Computer Science 3884 (2006), 149--16

Bayesian Networks and Sex-related Homicides

We present a statistical investigation on the domain of sex-related homicides. As general sociological and psychological theory on this specific type of crime is incomplete or even lacking, a data-driven approach is implemented. In detail, graphical modelling is applied to learn the dependency structure and several structure learning algorithms are combined to yield a skeleton corresponding to distinct Bayesian Networks. This graph is subsequently analysed and presents a distinction between an offender and a situation driven crime.Bayesian Networks, structure learning, offender profiling

Helium in Double-Detonation Models of Type Ia Supernovae

The double-detonation explosion model has been considered a candidate for explaining astrophysical transients with a wide range of luminosities. In this model, a carbon-oxygen white dwarf star explodes following detonation of a surface layer of helium. One potential signature of this explosion mechanism is the presence of unburned helium in the outer ejecta, left over from the surface helium layer. In this paper we present simple approximations to estimate the optical depths of important He I lines in the ejecta of double-detonation models. We use these approximations to compute synthetic spectra, including the He I lines, for double-detonation models obtained from hydrodynamical explosion simulations. Specifically, we focus on photospheric-phase predictions for the near-infrared 10830 \AA~and 2 $\mu$m lines of He I. We first consider a double detonation model with a luminosity corresponding roughly to normal SNe Ia. This model has a post-explosion unburned He mass of 0.03 $M_{\odot}$ and our calculations suggest that the 2 $\mu$m feature is expected to be very weak but that the 10830 \AA~feature may have modest opacity in the outer ejecta. Consequently, we suggest that a moderate-to-weak He I 10830 \AA~feature may be expected to form in double-detonation explosions at epochs around maximum light. However, the high velocities of unburned helium predicted by the model ($\sim 19,000$~km~s$^{-1}$) mean that the He I 10830 \AA~feature may be confused or blended with the C I 10690~\AA~line forming at lower velocities. We also present calculations for the He I 10830 \AA~and 2 $\mu$m lines for a lower mass (low luminosity) double detonation model, which has a post-explosion He mass of 0.077 $M_{\odot}$. In this case, both the He I features we consider are strong and can provide a clear observational signature of the double-detonation mechanism.Comment: 12 pages, 11 figures, accepted by A&

The interface of gravity and quantum mechanics illuminated by Wigner phase space

We provide an introduction into the formulation of non-relativistic quantum mechanics using the Wigner phase-space distribution function and apply this concept to two physical situations at the interface of quantum theory and general relativity: (i) the motion of an ensemble of cold atoms relevant to tests of the weak equivalence principle, and (ii) the Kasevich-Chu interferometer. In order to lay the foundations for this analysis we first present a representation-free description of the Kasevich-Chu interferometer based on unitary operators.Comment: 69 pages, 6 figures, minor changes to match the published version. The original publication is available at http://en.sif.it/books/series/proceedings_fermi or http://ebooks.iospress.nl/volumearticle/3809