Laboratory simulations of astrophysical jets and solar coronal loops: new results

An experimental program underway at Caltech has produced plasmas where the shape is neither fixed by the vacuum chamber nor fixed by an external coil set, but instead is determined by self-organization. The plasma dynamics is highly reproducible and so can be studied in considerable detail even though the morphology of the plasma is both complex and time-dependent. A surprising result has been the observation that self-collimating MHD-driven plasma jets are ubiquitous and play a fundamental role in the self-organization. The jets can be considered lab-scale simulations of astrophysical jets and in addition are intimately related to solar coronal loops. The jets are driven by the combination of the axial component of the J×B force and the axial pressure gradient resulting from the non-uniform pinch force associated with the flared axial current density. Behavior is consistent with a model showing that collimation results from axial non-uniformity of the jet velocity. In particular, flow stagnation in the jet frame compresses frozen-in azimuthal magnetic flux, squeezes together toroidal magnetic field lines, thereby amplifying the embedded toroidal magnetic field, enhancing the pinch force, and hence causing collimation of the jet

Seasonal variability of the warm Atlantic Water layer in the vicinity of the Greenland shelf break

The warmest water reaching the east and west coast of Greenland is found between 200?m and 600?m. Whilst important for melting Greenland's outlet glaciers, limited winter observations of this layer prohibit determination of its seasonality. To address this, temperature data from Argo profiling floats, a range of sources within the World Ocean Database and unprecedented coverage from marine-mammal borne sensors have been analysed for the period 2002-2011. A significant seasonal range in temperature (~1-2?°C) is found in the warm layer, in contrast to most of the surrounding ocean. The phase of the seasonal cycle exhibits considerable spatial variability, with the warmest water found near the eastern and southwestern shelf-break towards the end of the calendar year. High-resolution ocean model trajectory analysis suggest the timing of the arrival of the year's warmest water is a function of advection time from the subduction site in the Irminger Basin

Magnetically Driven Flows in Arched Plasma Structures

Laboratory experiments demonstrate high-speed plasma flows from both footpoints of arched magnetic flux tubes, resulting in bulk plasma transport into the flux tube and persistent axial collimation even as the flux tube lengthens and kinks. The measured flows are in agreement with the predictions of hoop force and collimation models involving fundamental MHD forces. These forces are expected to drive plasma acceleration in other open flux configurations with arched geometries, such as those found on the solar surface

Post-Foucauldian governmentality: what does it offer critical social policy analysis?

This article considers the theoretical perspective of post-Foucauldian governmentality, especially the insights and challenges it poses for applied researchers within the critical social policy tradition. The article firstly examines the analytical strengths of this approach to understanding power and rule in contemporary society, before moving on to consider its limitations for social policy. It concludes by arguing that these insights can be retained, and some of the weaknesses overcome, by adopting a ‘realist governmentality’ approach (Stenson 2005, 2008). This advocates combining traditional discursive analysis with more ethnographic methods in order to render visible the concrete activity of governing, and unravel the messiness, complexity and unintended consequences involved in the struggles around subjectivity

The Pediatric Sepsis Biomarker Risk Model (PERSEVERE) Biomarkers Predict Clinical Deterioration and Mortality in Immunocompromised Children Evaluated for Infection

Pediatric sepsis and bacterial infection cause significant morbidity and mortality worldwide, with immunocompromised patients being at particularly high risk of rapid deterioration and death. This study evaluated if PERSEVERE, PERSEVERE-II, or the PERSEVERE biomarkers, can reliably estimate the risk of clinical deterioration and 28-day mortality among immunocompromised pediatric patients. This is a single-center prospective cohort study conducted from July 2016 through September 2017 incorporating 400 episodes of suspected bacterial infection from the inpatient units at Cincinnati Children's Hospital Medical Center, a large, tertiary care children's hospital. The primary analysis assessed clinical deterioration within 72 hours of evaluation for infection. Secondarily, we assessed 28-day mortality. Clinical deterioration was seen in 15% of subjects. Twenty-eight day mortality was 5%, but significantly higher among critically ill patients. Neither PERSEVERE nor PERSEVERE-II performed well to predict clinical deterioration or 28-day mortality, thus we derived new stratification models using the PERSEVERE biomarkers with both high sensitivity and negative predictive value. In conclusion, we evaluated previously validated biomarker risk models in a novel population of largely non-critically ill immunocompromised pediatric patients, and attempted to stratify patients based on a new outcome metric, clinical deterioration. The new highly predictive models indicate common physiologic pathways to clinical deterioration or death from bacterial infection

The Scalar Meson f0(980) in Heavy-Meson Decays

A phenomenological analysis of the scalar meson f0(980) is performed that relies on the quasi-two body decays D and Ds -> f0(980)P, with P=pi, K. The two-body branching ratios are deduced from experimental data on D or Ds -> pi pi pi, K Kbar pi and from the f0(980) -> pi+ pi- and f0(980) -> K+ K- branching fractions. Within a covariant quark model, the scalar form factors F0(q2) for the transitions D and Ds -> f0(980) are computed. The weak D decay amplitudes, in which these form factors enter, are obtained in the naive factorization approach assuming a quark-antiquark state for the scalar and pseudoscalar mesons. They allow to extract information on the f0(980) wave function in terms of u-ubar, d-dbar and s-sbar pairs as well as on the mixing angle between the strange and non-strange components. The weak transition form factors are modeled by the one-loop triangular diagram using two different relativistic approaches: covariant light-front dynamics and dispersion relations. We use the information found on the f0(980) structure to evaluate the scalar and vector form factors in the transitions D and Ds -> f0(980), as well as to make predictions for B and Bs -> f0(980), for the entire kinematically allowed momentum range of q2.Comment: 45 pages, 9 figures and 9 tables. The use of dispersion relations to calculate the weak transition form factors is better justified. A more extensive discussion on the strange and non-strange flavor content mixing is introduced. Results unchanged. Version to appear in Phys. Rev.

Persistence of the immune response induced by BCG vaccination.

BACKGROUND: Although BCG vaccination is recommended in most countries of the world, little is known of the persistence of BCG-induced immune responses. As novel TB vaccines may be given to boost the immunity induced by neonatal BCG vaccination, evidence concerning the persistence of the BCG vaccine-induced response would help inform decisions about when such boosting would be most effective. METHODS: A randomised control study of UK adolescents was carried out to investigate persistence of BCG immune responses. Adolescents were tested for interferon-gamma (IFN-gamma) response to Mycobacterium tuberculosis purified protein derivative (M.tb PPD) in a whole blood assay before, 3 months, 12 months (n = 148) and 3 years (n = 19) after receiving teenage BCG vaccination or 14 years after receiving infant BCG vaccination (n = 16). RESULTS: A gradual reduction in magnitude of response was evident from 3 months to 1 year and from 1 year to 3 years following teenage vaccination, but responses 3 years after vaccination were still on average 6 times higher than before vaccination among vaccinees. Some individuals (11/86; 13%) failed to make a detectable antigen-specific response three months after vaccination, or lost the response after 1 (11/86; 13%) or 3 (3/19; 16%) years. IFN-gamma response to Ag85 was measured in a subgroup of adolescents and appeared to be better maintained with no decline from 3 to 12 months. A smaller group of adolescents were tested 14 years after receiving infant BCG vaccination and 13/16 (81%) made a detectable IFN-gamma response to M.tb PPD 14 years after infant vaccination as compared to 6/16 (38%) matched unvaccinated controls (p = 0.012); teenagers vaccinated in infancy were 19 times more likely to make an IFN-gamma response of > 500 pg/ml than unvaccinated teenagers. CONCLUSION: BCG vaccination in infancy and adolescence induces immunological memory to mycobacterial antigens that is still present and measurable for at least 14 years in the majority of vaccinees, although the magnitude of the peripheral blood response wanes from 3 months to 12 months and from 12 months to 3 years post vaccination. The data presented here suggest that because of such waning in the response there may be scope for boosting anti-tuberculous immunity in BCG vaccinated children anytime from 3 months post-vaccination. This supports the prime boost strategies being employed for some new TB vaccines currently under development

Still policing the crisis?

Writing this has been a troubling experience. Returning to a text 30 years on in this way combines intellectual, political and personal reflections in an unsettling way. These range from a powerful attachment to processes of collective or collaborative intellectual work that Policing the Crisis (PTC; Hall et al., 1978) embodied and enhanced to a rather depressed sense of how many things the book got right about the trajectory of the British social formation in the mid 1970s (other futures might have been preferable). And above all, there is a sense of what the book stands for in the emergence of cultural studies as an institutionalized academic field. As a way of trying to digest these different responses, I have tried to address three sorts of questions: why PTC mattered, where it belongs and why it continues to have echoes in the present