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Standardization, calibration and innovation: a special issue on lithic microwear method
YesThis paper introduces a special issue of the Journal of Archaeological Science that considers the current state and future directions in lithic microwear analysis. There is considerable potential for lithic microwear analysis to reconstruct past human behaviour as it can provide direct insight into past activities. Consequently, it is a technique worthy of significant additional investment and continued development. To further the cause of methodological maturation within microwear analysis and to promote standardization, calibration, and innovation, the following collection of papers present various approaches and perspectives on how greater methodological refinement and increased reliability of results can and should be achieved. Many of these papers were part of a session held at the 2011 Society for American Archaeology Meeting (SAA) in Sacramento, California, while others were selected from the 2012 International Conference on Use-Wear Analysis in Faro, Portugal. The purpose of the SAA session and this special themed issue is essentially two-fold. The first is to promote awareness of the need for methodological standardization, calibration, and continuing innovation. The second is to open a serious dialogue about how these aims could be pursued and achieved.AAE was supported by the AHRC (AH/J007935/1). HJL was supported by L’Équipe Archéometrie at the Laboratoires d’ Archéologie, a part of the Centre Interuniversitaire d’Études sur les Lettres, les Arts et les Traditions (CELAT) at Université Laval. DAM was supported by Fondation Fyssen and the University of Toronto. WJS was supported by Faculty Development Grant from Keene State College
A highly virulent variant of HIV-1 circulating in the Netherlands.
We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log <sub>10</sub> increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences-is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence