19 research outputs found
How to measure work functions from aqueous solutions
The recent application of concepts from condensed-matter physics to
photoelectron spectroscopy (PES) of volatile, liquid-phase systems has enabled
the measurement of electronic energetics of liquids on an absolute scale.
Particularly, vertical ionization energies, VIEs, of liquid water and aqueous
solutions, both in the bulk and at associated interfaces, can now be routinely
determined. These IEs are referenced to the local vacuum level, which is the
appropriate quantity for condensed matter with associated surfaces, including
liquids. Here, we connect this newly accessible energy level to another
important surface property, namely, the solution work function, e.
We lay out the prerequisites for and unique challenges of determining e
of aqueous solutions and liquids in general. We demonstrate - for a model
aqueous solution with a tetra-n-butylammonium iodide (TBAI) surfactant solute -
that concentration-dependent work functions, associated with the surface
dipoles generated by the segregated interfacial layer of TBA and Iions,
can be accurately measured under controlled conditions. We detail the nature of
surface potentials, uniquely tied to the nature of the flowing-liquid sample,
which must be eliminated or quantified to enable such measurements. This allows
us to refer measured spectra of aqueous solutions to the Fermi level and
quantitatively assign surfactant concentration-dependent spectral shifts to
competing work function and electronic-structure effects, the latter
determining, e.g., (electro)chemical reactivity. We describe the extension of
liquid-jet PES to quantitatively access concentration-dependent surface
descriptors that have so far been restricted to solid-phase measurements. These
studies thus mark the beginning of a new era in the characterization of the
interfacial electronic structure of aqueous solutions and liquids more
generally.Comment: Main manuscript: 26 pages, 7 figures. Supporting information: 5
pages, 5 figure
A randomized, placebo-controlled, double-blind, prospective trial to evaluate the effect of vildagliptin in new-onset diabetes mellitus after kidney transplantation
<p>Abstract</p> <p>Background</p> <p>New-onset diabetes mellitus after transplantation (NODAT), a frequent and serious complication after transplantation, is associated with decreased graft and patient survival. Currently, it is diagnosed and treated primarily according to existing guidelines for type II diabetes. To date, only a few trials have studied antidiabetic drugs in patients with NODAT. Vildagliptin is a novel dipeptidyl peptidase-4 (DPP-4) inhibitor that improves pancreatic islet function by enhancing both α- and ÎČ-cell responsiveness to increased blood glucose. Experimental data show potential protective effects of DPP-4 inhibitors on islet function after exogenous stress stimuli including immunosuppressants. Therefore, the therapy of NODAT with this class of compounds seems attractive. At present, vildagliptin is used to treat type II diabetes as monotherapy or in combination with other antidiabetic drugs, since that it efficiently decreases glycated hemoglobin (HbA1c) values. Additionally, vildagliptin has been shown to be safe in patients with moderately impaired kidney function. This study will evaluate the safety and efficacy of vildagliptin monotherapy in renal transplant recipients with recently diagnosed NODAT.</p> <p>Methods/Design</p> <p>This study is a randomized, placebo-controlled, double-blind, prospective phase II trial. Using the results of routinely performed oral glucose tolerance tests (OGTT) in stable renal transplant patients at our center, we will recruit patients without a history of diabetes and a 2 h glucose value surpassing 200 mg/dl (11.1 mmol/l). They are randomized to receive either 50 mg vildagliptin or placebo once daily. A total of 32 patients with newly diagnosed NODAT will be included. The primary endpoint is the difference in the 2 h glucose value between baseline and the repeated OGTT performed 3 months after treatment start, compared between the vildagliptin- and the placebo-group. Secondary endpoints include changes in HbA1c and fasting plasma glucose (FPG). The safety of vildagliptin in renal transplant patients will be assessed by the number of symptomatic hypoglycemic episodes (glucose <72 mg/dl or 4 mmol/l), the number of adverse events, and possible medication-associated side-effects.</p> <p>Discussion</p> <p>NODAT is a severe complication after kidney transplantation. Few trials have assessed the safety and efficacy of antidiabetic drugs for these patients. The purpose of this study is to assess the safety and efficacy of vildagliptin in renal transplant patients with NODAT.</p> <p>Trial Registration</p> <p>ClinicalTrials.gov NCT00980356</p
A Chirality-Based Quantum Leap
There is increasing interest in the study of chiral degrees of freedom occurring in matter and in electromagnetic fields. Opportunities in quantum sciences will likely exploit two main areas that are the focus of this Review: (1) recent observations of the chiral-induced spin selectivity (CISS) effect in chiral molecules and engineered nanomaterials and (2) rapidly evolving nanophotonic strategies designed to amplify chiral light-matter interactions. On the one hand, the CISS effect underpins the observation that charge transport through nanoscopic chiral structures favors a particular electronic spin orientation, resulting in large room-temperature spin polarizations. Observations of the CISS effect suggest opportunities for spin control and for the design and fabrication of room-temperature quantum devices from the bottom up, with atomic-scale precision and molecular modularity. On the other hand, chiral-optical effects that depend on both spin- and orbital-angular momentum of photons could offer key advantages in all-optical and quantum information technologies. In particular, amplification of these chiral light-matter interactions using rationally designed plasmonic and dielectric nanomaterials provide approaches to manipulate light intensity, polarization, and phase in confined nanoscale geometries. Any technology that relies on optimal charge transport, or optical control and readout, including quantum devices for logic, sensing, and storage, may benefit from chiral quantum properties. These properties can be theoretically and experimentally investigated from a quantum information perspective, which has not yet been fully developed. There are uncharted implications for the quantum sciences once chiral couplings can be engineered to control the storage, transduction, and manipulation of quantum information. This forward-looking Review provides a survey of the experimental and theoretical fundamentals of chiral-influenced quantum effects and presents a vision for their possible future roles in enabling room-temperature quantum technologies.ISSN:1936-0851ISSN:1936-086
Recommended from our members
Spin Selectivity in Photoemission from Self-Assembled Monolayers of Chiral Molecules
Spin-selective interactions between electrons and chiral molecules, described collectively by the chiral-induced spin selectivity (CISS) effect, have garnered increasing attention. The history of this burgeoning field, the predominant experimental techniques that have been employed to study the CISS effect, and the state of theoretical efforts to model this unexpected behavior are briefly reviewed. Herein, we demonstrate the use of ultraviolet photoelectron spectroscopy â a widely accessible and broadly applicable technique â to characterize the CISS effect in photoemission from self-assembled monolayers of peptides and proteins on ferromagnetic substrates. We subsequently report that the magnitude of the CISS effect in self-assembled monolayers of DNA can be enhanced through incorporation of heavy coordinating species within the chiral molecular framework, and moreover that the sign of the effect can be reversed by inverting the DNA molecular handedness. The relevance of the CISS effect as it pertains to both the development of highly effective room-temperature spintronic devices and to the elucidation of the origins of biomolecular homochirality and chirality dependent biochemical reactivity are discussed
Organic Semiconducing Thin Films: Device Applications and Beyond
Thesis (Master's)--University of Washington, 2016-06Organic semiconductors show great promise for device applications, particularly as organic thin film transistors (OTFTs) and organic photovoltaics (OPVs), due to their potential for low cost, high volume fabrication when compared to traditional inorganic semiconductors. While the performance of organic devices generally lags behind the more established inorganic devices, significant growth in the field of organic semiconductors has led to rapid improvements. In this thesis, device operation and characterization of OTFT and OPV systems are explained, the dramatic effects of fabrication procedures on the charge transport performance of OTFTs are demonstrated, and the reproducibility issues inherent to OPVs are explored. The potential for self-healing behavior in organic semiconductors is also investigated
Recommended from our members
Spin Selectivity in Photoemission from Self-Assembled Monolayers of Chiral Molecules
Spin-selective interactions between electrons and chiral molecules, described collectively by the chiral-induced spin selectivity (CISS) effect, have garnered increasing attention. The history of this burgeoning field, the predominant experimental techniques that have been employed to study the CISS effect, and the state of theoretical efforts to model this unexpected behavior are briefly reviewed. Herein, we demonstrate the use of ultraviolet photoelectron spectroscopy â a widely accessible and broadly applicable technique â to characterize the CISS effect in photoemission from self-assembled monolayers of peptides and proteins on ferromagnetic substrates. We subsequently report that the magnitude of the CISS effect in self-assembled monolayers of DNA can be enhanced through incorporation of heavy coordinating species within the chiral molecular framework, and moreover that the sign of the effect can be reversed by inverting the DNA molecular handedness. The relevance of the CISS effect as it pertains to both the development of highly effective room-temperature spintronic devices and to the elucidation of the origins of biomolecular homochirality and chirality dependent biochemical reactivity are discussed
Differential Charging in Photoemission from Mercurated DNA Monolayers on Ferromagnetic Films
Recommended from our members
Chemical Lift-Off Lithography of Metal and Semiconductor Surfaces
Chemical lift-off lithography (CLL) is a subtractive soft-lithographic technique that uses polydimethylsiloxane (PDMS) stamps to pattern self-assembled monolayers of functional molecules for applications ranging from biomolecule patterning to transistor fabrication. A hallmark of CLL is preferential cleavage of Au-Au bonds, as opposed to bonds connecting the molecular layer to the substrate, i.e., Au-S bonds. Herein, we show that CLL can be used more broadly as a technique to pattern a variety of substrates composed of coinage metals (Pt, Pd, Ag, Cu), transition and reactive metals (Ni, Ti, Al), and a semiconductor (Ge) using straightforward alkanethiolate self-assembly chemistry. We demonstrate high-fidelity patterning in terms of precise features over large areas on all surfaces investigated. We use patterned monolayers as chemical resists for wet etching to generate metal microstructures. Substrate atoms, along with alkanethiolates, were removed as a result of lift-off, as previously observed for Au. We demonstrate the formation of PDMS-stamp-supported bimetallic monolayers by performing CLL on two different metal surfaces using the same PDMS stamp. By expanding the scope of the surfaces compatible with CLL, we advance and generalize CLL as a method to pattern a wide range of substrates, as well as to produce supported metal monolayers, both with broad applications in surface and materials science
Recommended from our members
Spin-Dependent Ionization of Chiral Molecular Films
Spin selectivity in photo-emission from ferromagnetic substrates functionalized with chiral organic films was analyzed by ultraviolet photoelectron spectroscopy at room temperature. Using radiation with photon energy greater than the ionization potential of the adsorbed molecules, photoelectrons were collected that originated from both underlying ferromagnetic substrates and the organic films, with kinetic energies in the range of ca. 0-18 eV. We investigated chiral organic films composed of self-assembled monolayers of α-helical peptides and electrostatically adsorbed films of the protein, bovine serum albumin, with different α-helix and ÎČ-sheet contents. Ultraviolet photoelectron spectral widths were found to depend on substrate magnetization orientation and polarization, which we attribute to helicity-dependent molecular ionization cross sections arising from photoelectron impact, possibly resulting in spin-polarized holes. These interactions between spin-polarized photoelectrons and chiral molecules are physically manifested as differences in the measured photoionization energies of the chiral molecular films. Substrate magnetization-dependent ionization energies and work function values were deconvoluted using surface charge neutralization techniques, permitting the measurement of relative spin-dependent energy barriers to transmission through chiral organic films
How to measure work functions from aqueous solutions
The recent application of concepts from condensed-matter physics to photoelectron spectroscopy (PES) of volatile, liquid-phase systems has enabled the measurement of electronic energetics of liquids on an absolute scale. Particularly, vertical ionization energies, VIEs, of liquid water and aqueous solutions, both in the bulk and at associated interfaces, can now be accurately, precisely, and routinely determined. These IEs are referenced to the local vacuum level, which is the appropriate quantity for condensed matter with associated surfaces, including liquids. In this work, we connect this newly accessible energy level to another important surface property, namely, the solution work function, . We lay out the prerequisites for and unique challenges of determining of aqueous solutions and liquids in general. We demonstrate â for a model aqueous solution with a tetra-n-butylammonium iodide (TBAI) surfactant solute â that concentration-dependent work functions, associated with the surface dipoles generated by the segregated interfacial layer of TBA and I ions, can be accurately measured under controlled conditions. We detail the nature of surface potentials, uniquely tied to the nature of the flowing-liquid sample, which must be eliminated or quantified to enable such measurements. This allows us to refer aqueous-phase spectra to the Fermi level and to quantitatively assign surfactant-concentration-dependent spectral shifts to competing work function and electronic-structure effects, where the latter are typically associated with soluteâsolvent interactions in the bulk of the solution which determine, e.g., chemical reactivity. The present work describes the extension of liquid-jet PES to quantitatively access concentration-dependent surface descriptors that have so far been restricted to solid-phase measurements. Correspondingly, these studies mark the beginning of a new era in the characterization of the interfacial electronic structure of aqueous solutions and liquids more generally