Transgender Care within Family Medicine: Focusing on Feminizing Hormone Therapy

Transgender populations experience health disparities and barriers related to gender identity or expression. Many people who identify as transgender avoid or delay care because of perceived or real transphobia and discrimination by health care providers and institutions. Providers may benefit from easy access to information about people who identify as transgender and their health needs.https://scholarworks.uvm.edu/fmclerk/1857/thumbnail.jp

Afterglow

Stellar Kim is a fiction writer whose short stories have won several awards, including from The Atlantic Monthly, Iowa Review, and Ontario Review. Her recent work appears in The Best American Short Stories 2007, published by Houghton Mifflin and guest edited by Stephen King. Winner, The Cater V. Cooper Memorial Prize for Fiction, the Ontario Review, 2007

Awe and Wonder in Scientific Practice: Implications for the Relationship Between Science and Religion

This paper examines the role of awe and wonder in scientific practice. Drawing on evidence from psychological research and the writings of scientists and science communicators, I argue that awe and wonder play a crucial role in scientific discovery. They focus our attention on the natural world, encourage open-mindedness, diminish the self (particularly feelings of self-importance), help to accord value to the objects that are being studied, and provide a mode of understanding in the absence of full knowledge. I will flesh out implications of the role of awe and wonder in scientific discovery for debates on the relationship between science and religion. Abraham Heschel argued that awe and wonder are religious emotions because they reduce our feelings of self-importance, and thereby help to cultivate the proper reverent attitude towards God. Yet metaphysical naturalists such as Richard Dawkins insist that awe and wonder need not lead to any theistic commitments for scientists. The awe some scientists experience can be regarded as a form of non-theistic spirituality, which is neither a reductive naturalism nor theism. I will attempt to resolve the tension between these views by identifying some common ground

Evaluating Bahasa Inggris Maritim dan Perikanan Paket Keahlian Teknika Kapal Penangkapan Ikan Kelas X

This study would like to find out the extent to which the ESP textbooks Bahasa Inggris Maritim dan Perikanan Paket Keahlian: Teknika Kapal Penangkapan Ikan Kelas X Semester I (BIMP I) and Bahasa Inggris Maritim dan Perikanan Paket Keahlian: Teknika Kapal Penangkapan Ikan Kelas X Semester II (BIMP II) met the criterions of ESP textbooks evaluation proposed by Cunningsworth (1995). Content analysis was used to analyze the textbooks. It was found that one of the textbooks’ objectives was to enable students to use English as a communication tool. Both ESP textbooks presented vocabulary and discourse structures, covered relevant skills, encouraged learning activities relevant to student’s real life, and acknowledged student’s subject specific knowledge. The presentation of language items and language skills, however, were not fully in balance, and both ESP textbooks did cover speaking activities which replicated genuine English communication

Developing Models To Investigate Mechanisms Of Genomic Imprinting

Genomic imprinting is a conserved, essential process in mammalian development that regulates the expression of a small number of genes in a monoallelic, parent-or-origin-specific manner. Misregulation of imprinted genes is associated with imprinting disorders including Beckwith-Wiedemann syndrome (BWS) and Silver-Russell syndrome (SRS) that exhibit abnormal growth phenotypes. These disorders are associated with aberrant regulation of the imprinted loci in human 11p15 including the H19/IGF2 locus. Finding various alterations of 11p15 associated with BWS and SRS inspires investigation of imprinting mechanisms in human, which could provide insights into therapeutics. Mouse models have been fundamental to the study of mechanisms of imprinting, serving as a proxy for the orthologous human locus. However, elements that regulate genomic imprinting, the imprinting control regions (ICRs), often diverge across species. Thus, it is essential to first understand whether the diverged ICR has a species-specific role in regulating imprinting. In Chapter 2, we generated a mouse in which the human ICR sequence replaces the orthologous mouse ICR at the H19/Igf2 locus. We show that the imprinting mechanism has partially diverged between mouse and human, depending on the parental origin of the human ICR sequence in mouse. Additionally, we find that this mouse model is optimal for studying specific alterations associated with BWS and SRS. The partially diverging imprinting mechanism between mouse and human suggests that entirely human models are compelling alternatives. In Chapter 3, we demonstrate the derivation of induced pluripotent stem cells (iPSCs) from BWS patient fibroblasts. We find that the iPSCs exhibit proper epigenetic and transcriptional signatures of BWS. Although we find that certain aspect of epigenetic perturbation is inevitable in our iPSCs, the consequence of this perturbation remains unknown. Therefore, we propose that the iPSCs can be differentiated into clinically-relevant cell types to elucidate molecular mechanisms leading to BWS. Overall, the work in this dissertation underscores the versatile and complementary use of different model systems in investigating imprinting mechanisms. In addition to serving as platforms to model imprinting disorders, these models provide insights into the evolutionary perspective of imprinting as well as the significance of various epigenetic mechanisms that regulate imprinting

Prototype theory and emotion semantic change

An elaborate repertoire of emotions is one feature that dis-tinguishes humans from animals. Language offers a criticalform of emotion expression. However, it is unclear whetherthe meaning of an emotion word remains stable, and what fac-tors may underlie changes in emotion meaning. We hypothe-size that emotion word meanings have changed over time andthat the prototypicality of an emotion term drives this changebeyond general factors such as word frequency. We developa vector-space representation of emotion and show that thismodel replicates empirical findings on prototypicality judg-ments and basic categories of emotion. We provide evidencethat more prototypical emotion words have undergone lesschange in meaning than peripheral emotion words over the pastcentury, and that this trend holds within each family of emo-tion. Our work extends synchronic theories of emotion to itsdiachronic development and offers a computational character-ization of emotion semantics in natural language use