Repeatability, Drift, and Aftereffect of Three Types of Aircraft Altimeters

In a series of laboratory tests of a number of sensitive altimeters 5 (Air Force type C-12 and C-13) and of precision altimeters (Air Force 8 type MA-1), the repeatability was determined for the full range of each type of instrument the drift characteristics were determined during 1-hour periods at various altitudes, and the drift and aftereffect were measured for a variety of simulated flights representative of some civil and military operations. For comparable altitude ranges, the repeatability errors of the C-12 and C-13 types were generally of the same order while those of the MA-1 type were somewhat smaller. The drift and aftereffect of the C-12 instruments were smaller than those of the C-13 instruments, and the drift and aftereffect of the MA-1 altimeters were considerably smaller than those of both types of the sensitive instruments. The drift of each of the three types of altimeters was found to increase with altitude and the drift of the precision type was found to increase with increasing rate of altitude change preceding the drift test

Exome sequencing of Finnish isolates enhances rare-variant association power.

Exome-sequencing studies have generally been underpowered to identify deleterious alleles with a large effect on complex traits as such alleles are mostly rare. Because the population of northern and eastern Finland has expanded considerably and in isolation following a series of bottlenecks, individuals of these populations have numerous deleterious alleles at a relatively high frequency. Here, using exome sequencing of nearly 20,000 individuals from these regions, we investigate the role of rare coding variants in clinically relevant quantitative cardiometabolic traits. Exome-wide association studies for 64 quantitative traits identified 26 newly associated deleterious alleles. Of these 26 alleles, 19 are either unique to or more than 20 times more frequent in Finnish individuals than in other Europeans and show geographical clustering comparable to Mendelian disease mutations that are characteristic of the Finnish population. We estimate that sequencing studies of populations without this unique history would require hundreds of thousands to millions of participants to achieve comparable association power

Ethnicity in discourse: the interactional negotiation of ethnic boundaries in post-apartheid Namibia

To what extent can ethnic boundaries be transcended in interethnic interactions? We are tackling this question in reference to Namibia, a post-apartheid society marked by a legacy of ethnic and racial divisions. Relying on discourse as a source of data, we identify the strategies employed by Namibians in a range of interview data and semi-experimental interethnic interactions for either accentuating or attenuating interethnic boundaries. We identify these strategies at the levels of ethnic categorization, language choice/variation and the management of speaker turns, and place them in the perspective of the participants’ perspectives on ethnic Others. Our findings suggest that ethnic categories are salient in our data, although they do not exclude identification with superordinate categories in specific contexts. Our findings also show that patterns of categorization are reflected in language choice and turn management in the interactional context.Research grant awarded in 2012 to the authors by the French Institute of South Africa.http://www.tandfonline.com/loi/rers202016-09-30hb2016Afrikaan

Exome sequencing of Finnish isolates enhances rare-variant association power.

Exome-sequencing studies have generally been underpowered to identify deleterious alleles with a large effect on complex traits as such alleles are mostly rare. Because the population of northern and eastern Finland has expanded considerably and in isolation following a series of bottlenecks, individuals of these populations have numerous deleterious alleles at a relatively high frequency. Here, using exome sequencing of nearly 20,000 individuals from these regions, we investigate the role of rare coding variants in clinically relevant quantitative cardiometabolic traits. Exome-wide association studies for 64 quantitative traits identified 26 newly associated deleterious alleles. Of these 26 alleles, 19 are either unique to or more than 20 times more frequent in Finnish individuals than in other Europeans and show geographical clustering comparable to Mendelian disease mutations that are characteristic of the Finnish population. We estimate that sequencing studies of populations without this unique history would require hundreds of thousands to millions of participants to achieve comparable association power

Impact of SARS-CoV-2 pandemic on pancreatic cancer services and treatment pathways: United Kingdom experience.

INTRODUCTION The SARS-CoV-2 pandemic presented healthcare providers with an extreme challenge to provide cancer services. The impact upon the diagnostic and treatment capacity to treat pancreatic cancer is unclear. This study aimed to identify national variation in treatment pathways during the pandemic. METHODS A survey was distributed to all United Kingdom pancreatic specialist centres, to assess diagnostic, therapeutic and interventional services availability, and alterations in treatment pathways. A repeating methodology enabled assessment over time as the pandemic evolved. RESULTS Responses were received from all 29 centres. Over the first six weeks of the pandemic, less than a quarter of centres had normal availability of diagnostic pathways and a fifth of centres had no capacity whatsoever to undertake surgery. As the pandemic progressed services have gradually improved though most centres remain constrained to some degree. One third of centres changed their standard resectable pathway from surgery-first to neoadjuvant chemotherapy. Elderly patients, and those with COPD were less likely to be offered treatment during the pandemic. CONCLUSION The COVID-19 pandemic has affected the capacity of the NHS to provide diagnostic and staging investigations for pancreatic cancer. The impact of revised treatment pathways has yet to be realised