History of clinical transplantation

How transplantation came to be a clinical discipline can be pieced together by perusing two volumes of reminiscences collected by Paul I. Terasaki in 1991-1992 from many of the persons who were directly involved. One volume was devoted to the discovery of the major histocompatibility complex (MHC), with particular reference to the human leukocyte antigens (HLAs) that are widely used today for tissue matching.1 The other focused on milestones in the development of clinical transplantation.2 All the contributions described in both volumes can be traced back in one way or other to the demonstration in the mid-1940s by Peter Brian Medawar that the rejection of allografts is an immunological phenomenon.3,4 © 2008 Springer New York

Cryogenic target development for fast ignition with Z-pinch-driven fuel assembly

We are developing an alternative approach to indirect-drive fast ignition fusion targets in which a liquid cryogenic fuel layer is condensed in situ from a low pressure external gas supply and confined between a thick outer ablator shell and a thin inner shell. The shape and surface quality of the liquid fuel layer is determined entirely by the characteristics of the bounding shells. Liquid fuel targets of this type have a number of potential advantages including greatly reduced temperature control requirements and drastically reduced cost and complexity of the cryogenic support system compared to $\beta$-layed DT targets. This liquid fuel concept is particularly appropriate for a hemispherical capsule configuration with single-sided x-ray drive by a z-pinch source. Technology issues for concentric-shell liquid cryogenic target development and progress in thin inner hemispherical shell fabrication are discussed

RNA profiling in grey and white matter tissue yields clues towards multiple sclerosis etiology

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