Eine unbekannte Schrift von Bernardino Ochino

Recent work on the edition of Heinrich Bullinger’s correspondence from the year 1546 has unearthed an interesting letter by Ambrosius Blarer, the reformer of Constance. In a list of publications connected with the raging Schmalkaldic War, he mentions the pamphlet “Ein gesprech des Teütschen Lands und der hoffnung diese gegenwertige Kriegsleüff betreffend […]”, attributing it to the Italian reformer Bernardino Ochino. This article corroborates Ochino’s hitherto unknown authorship, as well as providing an edition of the pamphlet with a commentary and analysis

Feasibility of the preparation of cochleate suspensions from naturally derived phosphatidylserines

IntroductionCochleates are cylindrical particles composed of dehydrated phospholipid bilayers. They are typically prepared by addition of calcium ions to vesicles composed of negatively charged phospholipids such as phosphatidylserines (PS). Due to their high physical and chemical stability, they provide an interesting alternative over other lipid-based drug formulations for example to improve oral bioavailability or to obtain a parenteral sustained-release formulation.MethodsIn the present study, the feasibility to prepare cochleate suspensions from soy lecithin-derived phosphatidylserines (SPS) was investigated and compared to the “gold standard” dioleoyl-phosphatidylserine (DOPS) cochleates. The SPS lipids covered a large range of purities between 53 and >96% and computer-controlled mixing was evaluated for the preparation of the cochleate suspensions. Electron microscopic investigations were combined with small-angle x-ray diffraction (SAXD) and Laurdan generalized polarization (GP) analysis to characterize particle structure and lipid organization.ResultsDespite some differences in particle morphology, cochleate suspensions with similar internal lipid structure as DOPS cochleates could be prepared from SPS with high headgroup purity (≥96%). Suspensions prepared from SPS with lower purity still revealed a remarkably high degree of lipid dehydration and well-organized lamellar structure. However, the particle shape was less defined, and the typical cochleate cylinders could only be detected in suspensions prepared with higher amount of calcium ions. Finally, the study proves the feasibility to prepare suspensions of cochleates or cochleate-like particles directly from a calcium salt of soy-PS by dialysis

Christine Christ-von Wedel, Die Äbtissin, der Söldnerführer und ihre Töchter. Katharina von Zimmern im politischen Spannungsfeld der Reformationszeit, 2019

No abstract availabl

Conrad Gessner: Mithridate – Mithridates, 2009

No abstract available