Development of the German A-4 guidance and control system, 1939 - 1945: A memoir

The development by 1943 of a fully inertial navigational system for the German A-4 (V-2) missile is detailed. This flight control system used a triple-axis stabilized platform with two longitudinal accelerometers and one lateral accelerometer

Importance of the use of extraterrestrial resources to the economy of space flight beyond near-earth orbit

Importance of use of extraterrestrial resources to economy of space flight beyond near earth orbi

Fourth post-Newtonian effective-one-body Hamiltonians with generic spins

In a compact binary coalescence, the spins of the compact objects can have a significant effect on the orbital motion and gravitational-wave (GW) emission. For generic spin orientations, the orbital plane precesses, leading to characteristic modulations of the GW signal. The observation of precession effects is crucial to discriminate among different binary formation scenarios, and to carry out precise tests of General Relativity. Here, we work toward an improved description of spin effects in binary inspirals, within the effective-one-body (EOB) formalism, which is commonly used to build waveform models for LIGO and Virgo data analysis. We derive EOB Hamiltonians including the complete fourth post-Newtonian (4PN) conservative dynamics, which is the current state of the art. We place no restrictions on the spin orientations or magnitudes, or on the type of compact object (e.g., black hole or neutron star), and we produce the first generic-spin EOB Hamiltonians complete at 4PN order. We consider multiple spinning EOB Hamiltonians, which are more or less direct extensions of the varieties found in previous literature, and we suggest another simplified variant. Finally, we compare the circular-orbit, aligned-spin binding-energy functions derived from the EOB Hamiltonians to numerical-relativity simulations of the late inspiral. While finding that all proposed Hamiltonians perform reasonably well, we point out some interesting differences, which could guide the selection of a simpler, and thus faster-to-evolve EOB Hamiltonian to be used in future LIGO and Virgo inference studies

Canonical formulation of self-gravitating spinning-object systems

Based on the Arnowitt-Deser-Misner (ADM) canonical formulation of general relativity, a canonical formulation of gravitationally interacting classical spinning-object systems is given to linear order in spin. The constructed position, linear momentum and spin variables fulfill standard Poisson bracket relations. A spatially symmetric time gauge for the tetrad field is introduced. The achieved formulation is of fully reduced form without unresolved constraints, supplementary, gauge, or coordinate conditions. The canonical field momentum is not related to the extrinsic curvature of spacelike hypersurfaces in standard ADM form. A new reduction of the tetrad degrees of freedom to the Einstein form of the metric field is suggested.Comment: 6 pages. v2: extended version; identical to the published one. v3: corrected misprints in (24) and (39); improved notation; added note regarding a further reference

Reduced Hamiltonian for next-to-leading order Spin-Squared Dynamics of General Compact Binaries

Within the post Newtonian framework the fully reduced Hamiltonian (i.e., with eliminated spin supplementary condition) for the next-to-leading order spin-squared dynamics of general compact binaries is presented. The Hamiltonian is applicable to the spin dynamics of all kinds of binaries with self-gravitating components like black holes and/or neutron stars taking into account spin-induced quadrupolar deformation effects in second post-Newtonian order perturbation theory of Einstein's field equations. The corresponding equations of motion for spin, position and momentum variables are given in terms of canonical Poisson brackets. Comparison with a nonreduced potential calculated within the Effective Field Theory approach is made.Comment: 11 pages, minor changes to match published version at CQ

Clin. Dev. Immunol.

The transcription factors of the Rel/NF-kappa B family function as key regulators of innate and adoptive immunity. Tightly and temporally controlled activation of NF-kappa B-signalling pathways ensures prevention of harmful immune cell dysregulation, whereas a loss of control leads to pathological conditions such as severe inflammation, autoimmune disease, and inflammation-associated oncogenesis. Five family members have been identified in mammals: RelA (p65), c-Rel, RelB, and the precursor proteins NF kappa B1 (p105) and NF-kappa B2 (p100), that are processed into p50 and p52, respectively. While RelA-containing dimers are present in most cell types, c-Rel complexes are predominately found in cells of hematopoietic origin. In T-cell lymphocytes, certain genes essential for immune function such as Il2 and Foxp3 are directly regulated by c-Rel. Additionally, c-Rel-dependent IL-12 and IL-23 transcription by macrophages and dendritic cells is crucial for T-cell differentiation and effector functions. Accordingly, c-Rel expression in T cells and antigen-presenting cells (APCs) controls a delicate balance between tolerance and immunity. This review gives a selective overview on recent progress in understanding of diverse roles of c-Rel in regulating adaptive immunity

Non-Relativistic Gravitation: From Newton to Einstein and Back

We present an improvement to the Classical Effective Theory approach to the non-relativistic or Post-Newtonian approximation of General Relativity. The "potential metric field" is decomposed through a temporal Kaluza-Klein ansatz into three NRG-fields: a scalar identified with the Newtonian potential, a 3-vector corresponding to the gravito-magnetic vector potential and a 3-tensor. The derivation of the Einstein-Infeld-Hoffmann Lagrangian simplifies such that each term corresponds to a single Feynman diagram providing a clear physical interpretation. Spin interactions are dominated by the exchange of the gravito-magnetic field. Leading correction diagrams corresponding to the 3PN correction to the spin-spin interaction and the 2.5PN correction to the spin-orbit interaction are presented.Comment: 10 pages, 3 figures. v2: published version. v3: Added a computation of Einstein-Infeld-Hoffmann in higher dimensions within our improved ClEFT which partially confirms and partially corrects a previous computation. See notes added at end of introductio

Conservative and radiative dynamics in classical relativistic scattering and bound systems

As recent work continues to demonstrate, the study of relativistic scattering processes leads to valuable insights and computational tools applicable to the relativistic bound-orbit two-body problem. This is particularly relevant in the post-Minkowskian approach to the gravitational two-body problem, where the field has only recently reached a full description of certain physical observables for scattering orbits, including radiative effects, at the third post-Minkowskian (3PM) order. As an historically instructive simpler example, we consider here the analogous problem in electromagnetism in flat spacetime. We compute for the first time the changes in linear momentum of each particle and the total radiated linear momentum, in the relativistic classical scattering of two point-charges, at sixth order in the charges (analogous to 3PM order in gravity). We accomplish this here via direct iteration of the classical equations of motion, while making comparisons where possible to results from quantum scattering amplitudes, with the aim of contributing to the elucidation of conceptual issues and scalability on both sides. We also discuss further extensions to radiative quantities of recently established relations which analytically continue certain observables from the scattering regime to the regime of bound orbits, applicable for both the electromagnetic and gravitational cases

Radiation-reaction force and multipolar waveforms for eccentric, spin-aligned binaries in the effective-one-body formalism

While most binary inspirals are expected to have circularized before they enter the LIGO/Virgo frequency band, a small fraction of those binaries could have non-negligible orbital eccentricity depending on their formation channel. Hence, it is important to accurately model eccentricity effects in waveform models used to detect those binaries, infer their properties, and shed light on their astrophysical environment. We develop a multipolar effective-one-body (EOB) eccentric waveform model for compact binaries whose components have spins aligned or anti-aligned with the orbital angular momentum. The waveform model contains eccentricity effects in the radiation-reaction force and gravitational modes through second post-Newtonian (PN) order, including tail effects, and spin-orbit and spin-spin couplings. We recast the PN-expanded, eccentric radiation-reaction force and modes in factorized form so that the newly derived terms can be directly included in the state-of-the-art, quasi-circular--orbit EOB model currently used in LIGO/Virgo analyses (i.e., the {\tt SEOBNRv4HM} model)