Gauge Coupling Beta Functions in the Standard Model to Three Loops

In this paper we compute the three-loop corrections to the beta functions of the three gauge couplings in the Standard Model of particle physics using the minimal subtraction scheme and taking into account Yukawa and Higgs self couplings.Comment: 4 pages, 1 figure, v2: minor changes, references adde

Renormalization constants and beta functions for the gauge couplings of the Standard Model to three-loop order

We compute the beta functions for the three gauge couplings of the Standard Model in the minimal subtraction scheme to three loops. We take into account contributions from all sectors of the Standard Model. The calculation is performed using both Lorenz gauge in the unbroken phase of the Standard Model and background field gauge in the spontaneously broken phase. Furthermore, we describe in detail the treatment of $\gamma_5$ and present the automated setup which we use for the calculation of the Feynman diagrams. It starts with the generation of the Feynman rules and leads to the bare result for the Green's function of a given process.Comment: 44 pages, 9 figures; v2: sign in eq.(29) corrected; final result unchange

Finite top quark mass effects in NNLO Higgs boson production at LHC

We present next-to-next-to-leading order corrections to the inclusive production of the Higgs bosons at the CERN Large Hadron Collider (LHC) including finite top quark mass effects. Expanding our analytic results for the partonic cross section around the soft limit we find agreement with a very recent publication by Harlander and Ozeren \cite{Harlander:2009mq}.Comment: 15 page

Reconstruction of metabolic networks from high-throughput metabolite profiling data: in silico analysis of red blood cell metabolism

We investigate the ability of algorithms developed for reverse engineering of transcriptional regulatory networks to reconstruct metabolic networks from high-throughput metabolite profiling data. For this, we generate synthetic metabolic profiles for benchmarking purposes based on a well-established model for red blood cell metabolism. A variety of data sets is generated, accounting for different properties of real metabolic networks, such as experimental noise, metabolite correlations, and temporal dynamics. These data sets are made available online. We apply ARACNE, a mainstream transcriptional networks reverse engineering algorithm, to these data sets and observe performance comparable to that obtained in the transcriptional domain, for which the algorithm was originally designed.Comment: 14 pages, 3 figures. Presented at the DIMACS Workshop on Dialogue on Reverse Engineering Assessment and Methods (DREAM), Sep 200

Regionalization of the nervous system requires axial allocation prior to neural lineage commitment

Neural induction in vertebrates generates a central nervous system that extends the rostral-caudal length of the body. The prevailing view is that neural cells are initially induced with anterior (forebrain) identity, with caudalising signals then converting a proportion to posterior fates (spinal cord). To test this model, we used chromatin accessibility assays to define how cells adopt region-specific neural fates. Together with genetic and biochemical perturbations this identified a developmental time window in which genome-wide chromatin remodeling events preconfigure epiblast cells for neural induction. Contrary to the established model, this revealed that cells commit to a regional identity before acquiring neural identity. This 'primary regionalization' allocates cells to anterior or posterior regions of the nervous system, explaining how cranial and spinal neurons are generated at appropriate axial positions. These findings prompt a revision to models of neural induction and support the proposed dual evolutionary origin of the vertebrate central nervous system

Content, Social, and Metacognitive Statements: An Empirical Study Comparing Human-Human and Human-Computer Tutorial Dialogue

We present a study which compares human-human computer-mediated tutoring with two computer tutoring systems based on the same materials but differing in the type of feedback they provide. Our results show that there are significant differences in interaction style between human-human and human-computer tutoring, as well as between the two computer tutors, and that different dialogue characteristics predict learning gain in different conditions. We show that there are significant differences in the non-content statements that students make to human and computer tutors, but also to different types of computer tutors. These differences also affect which factors are correlated with learning gain and user satisfaction. We argue that ITS designers should pay particular attention to strategies for dealing with negative social and metacognitive statements, and also conduct further research on how interaction style affects human-computer tutoring. © 2010 Springer-Verlag Berlin Heidelberg

Semileptonic b --> u decays: lepton invariant mass spectrum

We compute O(alpha_s^2) QCD corrections to the lepton invariant mass spectrum in the decay b --> u l nu_l, relevant for the determination of the CKM matrix element |V_{ub}|. Our method can also be used to evaluate moments of the lepton energy distribution with an O(alpha_s^2) accuracy. The abelian part of our result gives the neutrino invariant mass spectrum in the muon decay and, upon integration, the O(alpha^2) correction to the muon lifetime.Comment: 5 pages, revte

Analytic Results for Virtual QCD Corrections to Higgs Production and Decay

We consider the production of a Higgs boson via gluon-fusion and its decay into two photons. We compute the NLO virtual QCD corrections to these processes in a general framework in which the coupling of the Higgs boson to the external particles is mediated by a colored fermion and a colored scalar. We present compact analytic results for these two-loop corrections that are expressed in terms of Harmonic Polylogarithms. The expansion of these corrections in the low and high Higgs mass regimes, as well as the expression of the new Master Integrals which appear in the reduction of the two-loop amplitudes, are also provided. For the fermionic contribution, we provide an independent check of the results already present in the literature concerning the Higgs boson and the production and decay of a pseudoscalar particle.Comment: 19 pages, 3 figures, version accepted by JHE