A Unique Radiation Scheme for the Treatment of High-Grade Non-Metastatic Soft Tissue Sarcoma: The Detroit Medical Center Experience

Purpose:This is the initial report on the utilization of combined photon irradiation followed by a neutron boost irradiation for the initial management of patients with high-grade non-metastatic soft tissue sarcoma (STS). We present data on local control, complications, disease-free survival and overall survival in patients at high risk for local relapse

Development of enteric coated sustained release minitablets containing mesalamine

The aim of this study was to develop and evaluate a multiparticulate modified release system, composed of minitablets with a sustained release matrix system coated with a pH-dependent release polymer, using mesalamine as a model drug. Polyox® WSR 1105 was the polymer used in the matrix system and Eudragit® L30D55 was used as a pH-dependent polymer. The minitablets (with 20%, 30% or 40% Polyox® concentration) were prepared by dry granulation, which led to good quality minitablets. The developed minitablets were coated in a fluidized bed at 8% of the coating level. Dissolution studies were performed in media that simulated the gastrointestinal tract (pH 1.4, 6.0 and 7.2) and showed that formulations with higher Polyox® concentrations were capable of retaining the drug release in pH 1.4. All formulations prolonged the drug release and presented zero-order kinetic behaviour. The Korsmeyer-Peppas model demonstrated that formulations with 20% or 30% of polymer exhibited anomalous transport behaviour, whilst the 40% sample exhibited super case II model transportation. Dissolution efficiency showed that only the formulations containing 20% and 40% polymer could be considered statistically different

Fürstengräber, Luxushäuser und Delphine - Archäologische Neuentdeckungen im daunischen Arpi (Nordapulien)

L'articolo esamina nuove scoperte nella zona urbana e nelle necropoli di Arpi in Daunia soprattutto del IV e III sec.a.C.: Tombe princcipesche (parzialmente dipinte), case di lusso con mosaici, statuette di delfin

Le ville romane dell'Italia e del Mediterraneo antico. Academic Meeting at the University of Tokyo, 1996

Il volume include una serie di contributi di colleghi italiani, tedeschi, americani e giapponesi su vari aspetti ed esempi di ville romane in Italia e nel Mediterraneo

Nella terra delle origini degli Etruschi

Vengono descritte varie zone dell'Etruria - soprattutto la zona delle necropoli rupestri all'interno dell'Etruria meridionale.

Bestimmung der Wasserdampf-Durchlaessigkeit von Baustoffen

With 10 tabs.SIGLETIB: RN 4625(1983,14) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman