Working with Ambivalence: Finding a Positive Identity for HIV/AIDS in South Africa.

Psychoanalytic theory draws attention to the way in which a positive identity can be asserted as a defence against underlying anxieties. Focusing specifically on the South African context, this paper highlights the way in which people attempt to forge a positive self-concept in the face of a stigmatised and self threatening HIV identity. In-depth interviews were conducted with twelve women living with HIV in a black South African township. Discursive and psychoanalytic understandings were used to explore the emotional experience of HIV/AIDS and its impact on both the participants of the study and ourselves as researchers. We elucidate the process by which our interviewees vacillated between conflicting notions of health and sickness; empowerment and disempowerment; strength and weakness; purity and contagion; and death and continuity. We argue that a more resilient self can be formed through recognition of both the positive and negative implications of an HIV diagnosis. We also maintain that it is necessary to move beyond the individualizing tendencies of mainstream psychology to recognise the social context and discursive practices which exacerbate stigma and influence the experience of those living with HIV/AIDS

Mental health is integral to public health: a call to scale up evidence-based services and develop mental health research

The Global Burden of Disease studies documented the challenges posed by mental illness. Mental illness comprised an estimated 12% of the global burden of disease in 2000, and is predicted to rise to 15% by 2020. Mental disorders comprise 5 of the 10 leading causes of health disability; it is predicted that, by 2030, unipolar depression will be the world's second most disabling health condition

SEROLOGICAL EVIDENCE OF LEPTOSPIRA SPP. IN THE LAMI TUCO-TUCO RODENTS (CTENOMYS LAMI)

Although rodents are reportedly the major reservoirs of Leptospira spp. in the wildlife of Brazil, the role of the widely distributed native tuco-tuco rodent (Ctenomys lami) has yet to be determined. Accordingly, a total of 40 serum and eight urine samples from wild C. lami were collected from June to September 2008 in the city of Porto Alegre, Southern Brazil. The serum samples were screened using the Microscopic Agglutination Test against 13 Leptospira spp. pathogenic serovars. A polymerase chain reaction (PCR) was performed to detect the presence of leptospiral DNA in the urine samples. Five (12.5%) of the serum samples had >100 antibody titer levels against one or more of the serovars. None of the urine samples yielded a positive PCR amplification; however, all of the source animals were also negative. In conclusion, although C. lami may be exposed to Leptospira spp., infection may be occasional because no detectable leptospiruria was found

Genetic deletion of hepatic NCOR1 protects from atherosclerosis by promoting alternative bile acid-metabolism and sterol excretion

BACKGROUND The nuclear receptor corepressor 1 (NCOR1) plays an important role in the regulation of gene expression in immunometabolic conditions by connecting chromatin-modifying enzymes, coregulators and transcription factors. NCOR1 has been shown to be involved in cardiometabolic diseases. Recently, we demonstrated that the deletion of macrophage NCOR1 aggravates atherosclerosis by promoting CD36-triggered foam cell formation via PPARG derepression. PURPOSE Since NCOR1 modulates the function of several key regulators involved in hepatic lipid and bile acid metabolism, we hypothesized that its deletion in hepatocytes alters lipid metabolism and atherogenesis. METHODS To test this hypothesis, we generated hepatocyte-specific Ncor1 knockout mice on a Ldlr-/- background. Besides assessing the progression of the disease in thoracoabdominal aortae en face, we analyzed hepatic cholesterol and bile acid metabolism at expression and functional levels. RESULTS Our data demonstrate that liver-specific Ncor1 knockout mice on an atherosclerosis-prone background develop less atherosclerotic lesions than controls. Interestingly, under chow diet, plasma cholesterol levels of liver-specific Ncor1 knockout mice were slightly higher compared to control, but strongly reduced compared to control mice after feeding them an atherogenic diet for 12 weeks. Moreover, the hepatic cholesterol content was decreased in liver-specific Ncor1 knockout compared to control mice. Our mechanistic data revealed that NCOR1 reprograms the synthesis of bile acids towards the alternative pathway, which in turn reduce bile hydrophobicity and enhances fecal cholesterol excretion. CONCLUSIONS Our data suggest that hepatic Ncor1 deletion in mice decreases atherosclerosis development by reprograming bile acid metabolism and enhancing fecal cholesterol excretion

ALICE: Study of Financial Hardship-Michigan

Through a series of new, standardized measurements, the United Way ALICE Reports present a broad picture of financial insecurity at the county and town level, and the reasons for why. What we found was startling -- the size of the workforce in each state that is struggling financially is much higher than traditional federal poverty guidelines suggest. The United Way ALICE Project is a grassroots movement stimulating a fresh, nonpartisan national dialogue about how to reverse the trend and improve conditions for this growing population of families living paycheck to paycheck

ALICE: Study of Financial Hardship-Indiana

Through a series of new, standardized measurements, the United Way ALICE Reports present a broad picture of financial insecurity at the county and town level, and the reasons for why. What we found was startling -- the size of the workforce in each state that is struggling financially is much higher than traditional federal poverty guidelines suggest. The United Way ALICE Project is a grassroots movement stimulating a fresh, nonpartisan national dialogue about how to reverse the trend and improve conditions for this growing population of families living paycheck to paycheck

ALICE: Study of Financial Hardship-Connecticut

Through a series of new, standardized measurements, the United Way ALICE Reports present a broad picture of financial insecurity at the county and town level, and the reasons for why. What we found was startling -- the size of the workforce in each state that is struggling financially is much higher than traditional federal poverty guidelines suggest. The United Way ALICE Project is a grassroots movement stimulating a fresh, nonpartisan national dialogue about how to reverse the trend and improve conditions for this growing population of families living paycheck to paycheck

Genomic resources for a historical collection of cultivated two-row European spring barley genotypes

Barley genomic resources are increasing rapidly, with the publication of a barley pangenome as one of the latest developments. Two-row spring barley cultivars are intensely studied as they are the source of high-quality grain for malting and distilling. Here we provide data from a European two-row spring barley population containing 209 different genotypes registered for the UK market between 1830 to 2014. The dataset encompasses RNA-sequencing data from six different tissues across a range of barley developmental stages, phenotypic datasets from two consecutive years of field-grown trials in the United Kingdom, Germany and the USA; and whole genome shotgun sequencing from all cultivars, which was used to complement the RNA-sequencing data for variant calling. The outcomes are a filtered SNP marker file, a phenotypic database and a large gene expression dataset providing a comprehensive resource which allows for downstream analyses like genome wide association studies or expression associations.</p

Identification of common variants associated with human hippocampal and intracranial volumes

Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer\u27s disease and is reduced in schizophrenia, major depression and mesial temporal lobe epilepsy. Whereas many brain imaging phenotypes are highly heritable, identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonance imaging (MRI) have led to underpowered studies. Here we report genome-wide association meta-analyses and replication for mean bilateral hippocampal, total brain and intracranial volumes from a large multinational consortium. The intergenic variant rs7294919 was associated with hippocampal volume (12q24.22; N = 21,151; P = 6.70 × 10(-16)) and the expression levels of the positional candidate gene TESC in brain tissue. Additionally, rs10784502, located within HMGA2, was associated with intracranial volume (12q14.3; N = 15,782; P = 1.12 × 10(-12)). We also identified a suggestive association with total brain volume at rs10494373 within DDR2 (1q23.3; N = 6,500; P = 5.81 × 10(-7))

Common genetic variants influence human subcortical brain structures

The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour and disease. To investigate how common genetic variants affect the structure of these brain regions, here we conduct genome-wide association studies of the volumes of seven subcortical regions and the intracranial volume derived from magnetic resonance images of 30,717 individuals from 50 cohorts. We identify five novel genetic variants influencing the volumes of the putamen and caudate nucleus. We also find stronger evidence for three loci with previously established influences on hippocampal volume and intracranial volume. These variants show specific volumetric effects on brain structures rather than global effects across structures. The strongest effects were found for the putamen, where a novel intergenic locus with replicable influence on volume (rs945270; P = 1.08 × 10(-33); 0.52% variance explained) showed evidence of altering the expression of the KTN1 gene in both brain and blood tissue. Variants influencing putamen volume clustered near developmental genes that regulate apoptosis, axon guidance and vesicle transport. Identification of these genetic variants provides insight into the causes of variability in human brain development, and may help to determine mechanisms of neuropsychiatric dysfunction