690 research outputs found
Определение эффективности нейтронного детектора из пластического сцинтиллятора o100?200 мм
Рассчитывается и экспериментально проверяется эффективность детектора. к нейтронам сверхвысоких (десятки и сотни МэВ) энергий
A Bisognano-Wichmann-like Theorem in a Certain Case of a Non Bifurcate Event Horizon related to an Extreme Reissner-Nordstr\"om Black Hole
Thermal Wightman functions of a massless scalar field are studied within the
framework of a ``near horizon'' static background model of an extremal R-N
black hole. This model is built up by using global Carter-like coordinates over
an infinite set of Bertotti-Robinson submanifolds glued together. The
analytical extendibility beyond the horizon is imposed as constraints on
(thermal) Wightman's functions defined on a Bertotti-Robinson sub manifold. It
turns out that only the Bertotti-Robinson vacuum state, i.e. , satisfies
the above requirement. Furthermore the extension of this state onto the whole
manifold is proved to coincide exactly with the vacuum state in the global
Carter-like coordinates. Hence a theorem similar to Bisognano-Wichmann theorem
for the Minkowski space-time in terms of Wightman functions holds with
vanishing ``Unruh-Rindler temperature''. Furtermore, the Carter-like vacuum
restricted to a Bertotti-Robinson region, resulting a pure state there, has
vanishing entropy despite of the presence of event horizons. Some comments on
the real extreme R-N black hole are given
Characterization of the KATRIN cryogenic pumping section
The KArlsruhe TRItium Neutrino (KATRIN) experiment aims to determine the effective anti-electron neutrino mass with a sensitivity of 0.2 eV/c by using the kinematics of tritium -decay. It is crucial to have a high signal rate which is achieved by a windowless gaseous tritium source producing 10 -electrons per second. These are guided adiabatically to the spectrometer section where their energy is analyzed. In order to maintain a low background rate below 0.01 cps, one essential criteria is to permanently reduce the flow of neutral tritium molecules between the source and the spectrometer section by at least 14 orders of magnitude. A differential pumping section downstream from the source reduces the tritium flow by seven orders of magnitude, while at least another factor of 10 is achieved by the cryogenic pumping section where tritium molecules are adsorbed on an approximately 3 K cold argon frost layer. In this paper, the results of the cryogenic pumping section commissioning measurements using deuterium are discussed. The cryogenic pumping section surpasses the requirement for the flow reduction of 10 by more than one order of magnitude. These results verify the predictions of previously published simulations
Neutrino mass from cosmology: Impact of high-accuracy measurement of the Hubble constant
Non-zero neutrino mass would affect the evolution of the Universe in
observable ways, and a strong constraint on the mass can be achieved using
combinations of cosmological data sets. We focus on the power spectrum of
cosmic microwave background (CMB) anisotropies, the Hubble constant H_0, and
the length scale for baryon acoustic oscillations (BAO) to investigate the
constraint on the neutrino mass, m_nu. We analyze data from multiple existing
CMB studies (WMAP5, ACBAR, CBI, BOOMERANG, and QUAD), recent measurement of H_0
(SHOES), with about two times lower uncertainty (5%) than previous estimates,
and recent treatments of BAO from the Sloan Digital Sky Survey (SDSS). We
obtained an upper limit of m_nu < 0.2eV (95% C.L.), for a flat LambdaCDM model.
This is a 40% reduction in the limit derived from previous H_0 estimates and
one-third lower than can be achieved with extant CMB and BAO data. We also
analyze the impact of smaller uncertainty on measurements of H_0 as may be
anticipated in the near term, in combination with CMB data from the Planck
mission, and BAO data from the SDSS/BOSS program. We demonstrate the
possibility of a 5 sigma detection for a fiducial neutrino mass of 0.1eV or a
95% upper limit of 0.04eV for a fiducial of m_nu = 0eV. These constraints are
about 50% better than those achieved without external constraint. We further
investigate the impact on modeling where the dark-energy equation of state is
constant but not necessarily -1, or where a non-flat universe is allowed. In
these cases, the next-generation accuracies of Planck, BOSS, and 1% measurement
of H_0 would all be required to obtain the limit m_nu < 0.05 - 0.06eV (95%
C.L.) for the fiducial of m_nu = 0eV. The independence of systematics argues
for pursuit of both BAO and H_0 measurements.Comment: 22 pages, 6 figures, 12 table
A gene expression-based model predicts outcome in children with intermediate-risk classical Hodgkin lymphoma
Classical Hodgkin lymphoma (cHL) is a common malignancy in children and adolescents. Although cHL is highly curable, treatment with chemotherapy and radiation often come at the cost of long-term toxicity and morbidity. Effective risk-stratification tools are needed to tailor therapy. Here, we used gene expression profiling (GEP) to investigate tumor microenvironment (TME) biology, to determine molecular correlates of treatment failure, and to develop an outcome model prognostic for pediatric cHL. A total of 246 formalin-fixed, paraffin-embedded tissue biopsies from patients enrolled in the Children’s Oncology Group trial AHOD0031 were used for GEP and compared with adult cHL data. Eosinophil, B-cell, and mast cell signatures were enriched in children, whereas macrophage and stromal signatures were more prominent in adults. Concordantly, a previously published model for overall survival prediction in adult cHL did not validate in pediatric cHL. Therefore, we developed a 9-cellular component model reflecting TME composition to predict event-free survival (EFS). In an independent validation cohort, we observed a significant difference in weighted 5-year EFS between high-risk and low-risk groups (75.2% vs 90.3%; log-rank P = .0138) independent of interim response, stage, fever, and albumin. We demonstrate unique disease biology in children and adolescents that can be harnessed for risk-stratification at diagnosis. This trial was registered at www.clinicaltrials.gov as #NCT00025259
The KATRIN Pre-Spectrometer at reduced Filter Energy
The KArlsruhe TRItium Neutrino experiment, KATRIN, will determine the mass of
the electron neutrino with a sensitivity of 0.2 eV (90% C.L.) via a measurement
of the beta-spectrum of gaseous tritium near its endpoint of E_0 =18.57 keV. An
ultra-low background of about b = 10 mHz is among the requirements to reach
this sensitivity. In the KATRIN main beam-line two spectrometers of MAC-E
filter type are used in a tandem configuration. This setup, however, produces a
Penning trap which could lead to increased background. We have performed test
measurements showing that the filter energy of the pre-spectrometer can be
reduced by several keV in order to diminish this trap. These measurements were
analyzed with the help of a complex computer simulation, modeling multiple
electron reflections both from the detector and the photoelectric electron
source used in our test setup.Comment: 22 pages, 12 figure
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