Predicting the year of birth by the ¹⁴C of eye lens crystallines.

<p>The year of birth of a person may be predicted from the ¹⁴C content of the eye-lens crystallines. In an over-simplistic picture the eye lens crystallines are formed at the birth year of the individual. The year of birth predicted in that way (red circles, showing only the centre value of the 95% confidence interval) is close to the actual yeat but evidently different, in particular for the oldest individuals. More accurate results are obtained by using our model, because it takes into account that the crystallines grow later in life too: The resulting predictions (black vertical bars, showing the 95% confidence interval) are in agreement with the actual values in all cases. The two ways of predicting the year of birth correspond to using the black (atmospheric) or the red (eye-lens model) curve in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001529#pone-0001529-g001" target="_blank">Fig. 1</a>, respectively. The red line shows the ideal 1∶1 ratio between the predicted and actual year of birth.</p

The formation of eye lens crystallines determined by ¹⁴C.

<p>Nuclear bomb tests during 1955–63 produced large amounts of ¹⁴C, which after this period has declined exponentially (thin, grey line). Comparing the amount of ¹⁴C in eye-lens crystallines (red circles, plotted as a function of the year of birth) with the atmospheric concentration in units of pmC (percent modern Carbon) has made it possible to investigate the timing of the formation process. The red curve shows the output from our resulting lens-formation model, which provides the basis for predicting the year of birth accurately (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001529#pone-0001529-g002" target="_blank">Fig. 2</a>).</p

Design of low power and low area passive sigma delta modulators for audio applications

This book presents the study, design, modulation, optimization and implementation of low power, passive DT-ΣΔMs for use in audio applications. The high gain and bandwidth amplifier normally used for integration in ΣΔ modulation, is replaced by passive, switched-capacitor branches working under the Ultra Incomplete Settling (UIS) condition, leading to a reduction of the consumed power. The authors describe a design process that uses high level models and an optimization process based in genetic algorithms to achieve the desired performance

Applied graphic work of the painter Jiří Balcar

The Bachelor thesis Applied graphic work of the painter Jiří Balcar aims to discover and summarize Balcar's applied work throughout his life. The thesis is divided into two main parts: the first deals with the layout of books and periodicals, the second one looks at the design of film posters. The chapter on designing the book outlines the problem of illustration. The main focus of this study was to find a connection between Balcar's paintings and applied art. The same way as in Balcar's graphics and paintings, he goes through applied arts from expressionist depiction of a man in the city over lettristic Decrees to abstraction. After 1965 he returns again to figuration and to a man, surrounded by artifacts, referring to the modern contemporary world. However, in addition to this broad similarity, making posters and some graphic design publications shows another dimension of his work that does not appear in the paintings and graphics. This thesis is primarily a monograph; the Czech environment and the global context had to be completely removed due to the limited scope of this work

Minor allele frequency (MAF) and odds ratio (OR) of <i>MC1R</i> variants in melanoma cases/families compared to the Danish population.

<p>Minor allele frequency (MAF) and odds ratio (OR) of <i>MC1R</i> variants in melanoma cases/families compared to the Danish population.</p

Age at first melanoma in <i>CDKN2A</i> mutation carriers compared to age of first melanoma in individuals with melanoma and no <i>CDKN2A</i> mutation.

<p>Families with a <i>BAP1</i> mutation are not included, nor are individuals with UM.</p><p>Age at first melanoma in <i>CDKN2A</i> mutation carriers compared to age of first melanoma in individuals with melanoma and no <i>CDKN2A</i> mutation.</p

Characteristics of the 13 individuals/families with identified <i>CDKN2A</i> mutations.

<p>SCC: squamous cell carcinoma</p><p>CLL: chronic lymphocytic leukemia</p><p>RCC: renal cell carcinoma</p><p>Characteristics of the 13 individuals/families with identified <i>CDKN2A</i> mutations.</p

Flow-chart of melanoma cases included in the study.

<p>Flow-chart of melanoma cases included in the study.</p

sj-docx-1-msj-10.1177_13524585231200720 – Supplemental material for Microfibrillar-associated protein 4 as a potential marker of acute relapse in inflammatory demyelinating diseases of the central nervous system: Pathological and clinical aspects

Supplemental material, sj-docx-1-msj-10.1177_13524585231200720 for Microfibrillar-associated protein 4 as a potential marker of acute relapse in inflammatory demyelinating diseases of the central nervous system: Pathological and clinical aspects by Sara Samadzadeh, Mads Nikolaj Olesen, Martin Wirenfeldt, Sören Möller, Tatsuro Misu, Kerstin Soelberg, Jette Lautrup Frederiksen, Steffen Heegaard, Sara Mariotto, Kazuo Fujihara, Klemens Ruprecht, Thomas Levin Andersen, Romain Marignier, Søren Thue Lillevang, Eoin P Flanagan, Sean J Pittock, Ho Jin Kim, Jeffrey L Bennett, Friedemann Paul, Grith Lykke Sorensen, Brian G Weinshenker, Hans Lassmann and Nasrin Asgari in Multiple Sclerosis Journal</p

MAF and OR of <i>MITF</i> p.E318K in this study compared to the Danish population, and compared to other cohorts of CM patients.

<p>MAF and OR of <i>MITF</i> p.E318K in this study compared to the Danish population, and compared to other cohorts of CM patients.</p