Additional file 1 of Needs of amyloidosis patients and their care providers: design & first results of the AMY-NEEDS research and care program

Additional file 1. Table 1: Categories

Additional file 1: of Control of cardiovascular risk factors and its determinants in the general population– findings from the STAAB cohort study

Table S1. Definition of uncontrolled cardiovascular risk factors. Definition of the six uncontrolled cardiovascular risk factors (blood pressure, glycemic control, LDL cholesterol, tabaco abuse, physically inactive, overweight) and their subgroups (PDF 337kb

Additional file 2: of Control of cardiovascular risk factors and its determinants in the general population– findings from the STAAB cohort study

Table S2. Sensitivity analysis according to sex. Odds ratios (OR) (95%-CI) for 3–6 (referent: 0–2) insufficiently controlled cardiovascular risk factors adjusted for sociodemographic status stratified by sex (PDF 343 kb

Typical cardiac magnetic resonance imaging (cMRI) (A) and echocardiography (B) of patients with normal sphericity index (SI; right row) and elevated SI (left row).

<p>Note the pathological late enhancement (LE; white arrow) in the cMRI and the more spherical shape of the LV in the left row. SI; sphericity index, EDV; end-diastolic volume.</p

ROC curves of different echocardiographic parameters to identify patients with fast progression of late enhancement (LE).

<p>Parameters in the legend are ordered by the AUC. EDV, End-diastolic volume; EF, Ejection fraction; FS, Fractional shortening; LA, Left atrial diameter; SBP, Systolic blood pressure; SI, Sphericity index.</p

Scatter plot of annual progression rate of myocardial fibrosis versus the alterations in geometry.

<p>On the x-axis values of the sphericity index (SI, parameter for geometry) and on the y-axis the annual progression of late enhancement (LE, parameter for fibrosis) is displayed. The size of the red dots represents the systolic blood pressure (SBP) at baseline. The vertical line indicates the pathological value of the SI. Note the appearance of high SI in combination with elevated SBP and high progression rate. EDV; End-diastolic volume.</p

Data_Sheet_1_Profiles of cognitive impairment in chronic heart failure—A cluster analytic approach.pdf

BackgroundCognitive impairment is a major comorbidity in patients with chronic heart failure (HF) with a wide range of phenotypes. In this study, we aimed to identify and compare different clusters of cognitive deficits.MethodsThe prospective cohort study “Cognition.Matters-HF” recruited 147 chronic HF patients (aged 64.5 ± 10.8 years; 16.2% female) of any etiology. All patients underwent extensive neuropsychological testing. We performed a hierarchical cluster analysis of the cognitive domains, such as intensity of attention, visual/verbal memory, and executive function. Generated clusters were compared exploratively with respect to the results of cardiological, neurological, and neuroradiological examinations without correction for multiple testing.ResultsDendrogram and the scree plot suggested three distinct cognitive profiles: In the first cluster, 42 patients (28.6%) performed without any deficits in all domains. Exclusively, the intensity of attention deficits was seen in the second cluster, including 55 patients (37.4%). A third cluster with 50 patients (34.0%) was characterized by deficits in all cognitive domains. Age (p = 0.163) and typical clinical markers of chronic HF, such as ejection fraction (p = 0.222), 6-min walking test distance (p = 0.138), NT-proBNP (p = 0.364), and New York Heart Association class (p = 0.868) did not differ between clusters. However, we observed that women (p = 0.012) and patients with previous cardiac valve surgery (p = 0.005) prevailed in the “global deficits” cluster and the “no deficits” group had a lower prevalence of underlying arterial hypertension (p = 0.029). Total brain volume (p = 0.017) was smaller in the global deficit cluster, and serum levels of glial fibrillary acidic protein were increased (p = 0.048).ConclusionApart from cognitively healthy and globally impaired HF patients, we identified a group with deficits only in the intensity of attention. Women and patients with previous cardiac valve surgery are at risk for global cognitive impairment when suffering HF and could benefit from special multimodal treatment addressing the psychosocial condition.</p

Multivariate logistic regression analysis for correlation with rapid progression of late enhancement.

<p>SI, sphericity index</p><p>SBP, systolic blood pressure</p><p>LA, left atrial diameter</p><p>IVST, interventricular septal thickness</p><p>EF, ejection fraction</p><p>EDV, end-diastolic volume</p><p>FS, fractional shortening</p><p>NT-proBNP, n-terminal propeptide of brain natriuretic peptide</p><p>OR, odds ratio</p><p>CI, confidence interval</p><p>AUC, area under the curve</p><p>* p-value <0.05 for ROC-analysis.</p><p>Multivariate logistic regression analysis for correlation with rapid progression of late enhancement.</p

Baseline characteristics of study participants in the total sample and stages of Fabry cardiomyopathy.

<p>Data in parenthesis are % of total</p><p>ACR, Albumine-creatinine-ratio</p><p>CM, cardiomyopathy</p><p>GI, gastrointestinal</p><p>TIA, transient ischemic attack</p><p>SBP, systolic blood pressure</p><p>DBP, diastolic blood presssure</p><p>AT, angiotensin</p><p>ACE, angiotensin converting enzyme</p><p>GFR, glomerular filtration rate</p><p>NYHA, New York Heart assosiation</p><p>NT-proBNP, N-terminal of brain natriuretic peptide</p><p>Hb, haemoglobin.</p><p>Significance at level 0.05 is indicated by</p><p>* for early vs. intermediate stage</p><p>† for intermediate vs. severe stage</p><p>‡ for early vs. severe stage</p><p>Baseline characteristics of study participants in the total sample and stages of Fabry cardiomyopathy.</p

Overview of presumed factors and their interrelation influencing the progression of Fabry cardiomyopathy.

<p>BNP, Brain-natriuretic peptide; EDV, End-diastolic volume; GB3, globotriaosylceramide; LA, Left atrium; LV, Left ventricle.</p