91 research outputs found
Mortality in kittens is associated with a shift in ileum mucosa-associated enteroccoci from E. hirae to biofilm-forming E. faecalis and adherent E. coli
Approximately ~15% of foster kittens die before 8-wks of age with most of these kittens demonstrating clinical signs or post-mortem evidence of enteritis. While a specific cause of enteritis is not determined in most cases; these kittens are often empirically administered probiotics that contain enterococci. The enterococci are members of the commensal intestinal microbiota but can also function as opportunistic pathogens. Given the complicated role of enterococci in health and disease, it would be valuable to better understand what constitutes a “healthy” enterococcal community in these kittens and how this microbiota is impacted by severe illness. In this study, we characterize the ileum mucosa-associated enterococcal community of 50 apparently healthy and 50 terminally ill foster kittens. In healthy kittens, E. hirae was the most common species of ileum mucosa-associated enterococci and was often observed to adhere extensively to the small intestinal epithelium. These E. hirae isolates generally lacked virulence traits. In contrast, non-E. hirae enterococci, notably E. faecalis, were more commonly isolated from the ileum mucosa of kittens with terminal illness. Isolates of E. faecalis had numerous virulence traits and multiple antimicrobial resistance. Moreover, attachment of E. coli to the intestinal epithelium was significantly associated with terminal illness and was not observed in any kitten with adherent E. hirae. These findings identify a significant difference in species of enterococci cultured from the ileum mucosa of kittens with terminal illness compared to healthy kittens. In contrast to prior case studies that associate enteroadherent E. hirae with diarrhea in young animals, these controlled studies identified E. hirae as more often isolated from healthy kittens and adherence of E. hirae as more common and extensive in healthy compared to sick kittens
Non-Markovian Persistence and Nonequilibrium Critical Dynamics
The persistence exponent \theta for the global order parameter, M(t), of a
system quenched from the disordered phase to its critical point describes the
probability, p(t) \sim t^{-\theta}, that M(t) does not change sign in the time
interval t following the quench. We calculate \theta to O(\epsilon^2) for model
A of critical dynamics (and to order \epsilon for model C) and show that at
this order M(t) is a non-Markov process. Consequently, \theta is a new
exponent. The calculation is performed by expanding around a Markov process,
using a simplified version of the perturbation theory recently introduced by
Majumdar and Sire [Phys. Rev. Lett. _77_, 1420 (1996); cond-mat/9604151].Comment: 4 pages, Revtex, no figures, requires multicol.st
Percolation theory applied to measures of fragmentation in social networks
We apply percolation theory to a recently proposed measure of fragmentation
for social networks. The measure is defined as the ratio between the
number of pairs of nodes that are not connected in the fragmented network after
removing a fraction of nodes and the total number of pairs in the original
fully connected network. We compare with the traditional measure used in
percolation theory, , the fraction of nodes in the largest cluster
relative to the total number of nodes. Using both analytical and numerical
methods from percolation, we study Erd\H{o}s-R\'{e}nyi (ER) and scale-free (SF)
networks under various types of node removal strategies. The removal strategies
are: random removal, high degree removal and high betweenness centrality
removal. We find that for a network obtained after removal (all strategies) of
a fraction of nodes above percolation threshold, . For fixed and close to percolation threshold
(), we show that better reflects the actual fragmentation. Close
to , for a given , has a broad distribution and it is
thus possible to improve the fragmentation of the network. We also study and
compare the fragmentation measure and the percolation measure
for a real social network of workplaces linked by the households of the
employees and find similar results.Comment: submitted to PR
Influence of the intestinal microbiota on disease susceptibility in kittens with experimentally-induced carriage of atypical enteropathogenic Escherichia coli
Typical enteropathogenic E. coli (tEPEC) carries the highest hazard of death in children with diarrhea and atypical EPEC (aEPEC) was recently identified as significantly associated with diarrheal mortality in kittens. In both children and kittens there is a significant association between aEPEC burden and diarrheal disease, however the infection can be found in individuals with and without diarrhea. It remains unclear to what extent, under what conditions, or by what mechanisms aEPEC serves as a primary pathogen in individuals with diarrhea. It seems likely that a combination of host and bacterial factors enable aEPEC to cause disease in some individuals and not in others. The purpose of this study was to determine the impact of aEPEC on intestinal function and diarrhea in kittens following experimentally-induced carriage and the influence of a disrupted intestinal microbiota on disease susceptibility. Results of this study identify aEPEC as a potential pathogen in kittens. In the absence of disruption to the intestinal microbiota, kittens are resistant to clinical signs of aEPEC carriage but demonstrate significant occult changes in intestinal absorption and permeability. Antibiotic-induced disruption of the intestinal microbiota prior to infection increases subsequent intestinal water loss as determined by % fecal wet weight. Enrichment of the intestinal microbiota with a commensal member of the feline mucosa-associated microbiota, Enterococcus hirae, ameliorated the effects of aEPEC experimental infection on intestinal function and water loss. These observations begin to unravel the mechanisms by which aEPEC infection may be able to exploit susceptible hosts.Peer reviewe
Search for Interstellar Water in the Translucent Molecular Cloud toward HD 154368
We report an upper limit of 9 x 10^{12} cm-2 on the column density of water
in the translucent cloud along the line of sight toward HD 154368. This result
is based upon a search for the C-X band of water near 1240 \AA carried out
using the Goddard High Resolution Spectrograph of the Hubble Space Telescope.
Our observational limit on the water abundance together with detailed chemical
models of translucent clouds and previous measurements of OH along the line of
sight constrain the branching ratio in the dissociative recombination of H_3O+
to form water. We find at the level that no more than 30% of
dissociative recombinations of H_3O+ can lead to H_2O. The observed spectrum
also yielded high-resolution observations of the Mg II doublet at 1239.9 \AA
and 1240.4 \AA, allowing the velocity structure of the dominant ionization
state of magnesium to be studied along the line of sight. The Mg II spectrum is
consistent with GHRS observations at lower spectral resolution that were
obtained previously but allow an additional velocity component to be
identified.Comment: Accepted by ApJ, uses aasp
On the relevance of percolation theory to the vulcanization transition
The relationship between vulcanization and percolation is explored from the
perspective of renormalized local field theory. We show rigorously that the
vulcanization and percolation correlation functions are governed by the same
Gell--Mann-Low renormalization group equation. Hence, all scaling aspects of
the vulcanization transition are reigned by the critical exponents of the
percolation universality class.Comment: 9 pages, 2 figure
Domain Growth in a 1-D Driven Diffusive System
The low-temperature coarsening dynamics of a one-dimensional Ising model,
with conserved magnetisation and subject to a small external driving force, is
studied analytically in the limit where the volume fraction \mu of the minority
phase is small, and numerically for general \mu. The mean domain size L(t)
grows as t^{1/2} in all cases, and the domain-size distribution for domains of
one sign is very well described by the form P_l(l) \propto
(l/L^3)\exp[-\lambda(\mu)(l^2/L^2)], which is exact for small \mu (and possibly
for all \mu). The persistence exponent for the minority phase has the value 3/2
for \mu \to 0.Comment: 8 pages, REVTeX, 7 Postscript figures, uses multicol.sty and
epsf.sty. Submitted to Phys. Rev.
Diluted Networks of Nonlinear Resistors and Fractal Dimensions of Percolation Clusters
We study random networks of nonlinear resistors, which obey a generalized
Ohm's law, . Our renormalized field theory, which thrives on an
interpretation of the involved Feynman Diagrams as being resistor networks
themselves, is presented in detail. By considering distinct values of the
nonlinearity r, we calculate several fractal dimensions characterizing
percolation clusters. For the dimension associated with the red bonds we show
that at least to order {\sl O} (\epsilon^4),
with being the correlation length exponent, and , where d
denotes the spatial dimension. This result agrees with a rigorous one by
Coniglio. Our result for the chemical distance, d_{\scriptsize min} = 2 -
\epsilon /6 - [ 937/588 + 45/49 (\ln 2 -9/10 \ln 3)] (\epsilon /6)^2 + {\sl O}
(\epsilon^3) verifies a previous calculation by one of us. For the backbone
dimension we find D_B = 2 + \epsilon /21 - 172 \epsilon^2 /9261 + 2 (- 74639 +
22680 \zeta (3))\epsilon^3 /4084101 + {\sl O} (\epsilon^4), where , in agreement to second order in with a two-loop
calculation by Harris and Lubensky.Comment: 29 pages, 7 figure
Algebraic Self-Similar Renormalization in Theory of Critical Phenomena
We consider the method of self-similar renormalization for calculating
critical temperatures and critical indices. A new optimized variant of the
method for an effective summation of asymptotic series is suggested and
illustrated by several different examples. The advantage of the method is in
combining simplicity with high accuracy.Comment: 1 file, 44 pages, RevTe
Critical Dynamics of Gelation
Shear relaxation and dynamic density fluctuations are studied within a Rouse
model, generalized to include the effects of permanent random crosslinks. We
derive an exact correspondence between the static shear viscosity and the
resistance of a random resistor network. This relation allows us to compute the
static shear viscosity exactly for uncorrelated crosslinks. For more general
percolation models, which are amenable to a scaling description, it yields the
scaling relation for the critical exponent of the shear
viscosity. Here is the thermal exponent for the gel fraction and
is the crossover exponent of the resistor network. The results on the shear
viscosity are also used in deriving upper and lower bounds on the incoherent
scattering function in the long-time limit, thereby corroborating previous
results.Comment: 34 pages, 2 figures (revtex, amssymb); revised version (minor
changes
- …