DuraSpace's Solution Communities: Marshalling the Resources for Open-source Development

In his opening plenary address to the Open Repositories Conference, James Hilton made the statement that "open-source software is free like a puppy." This statement succinctly summarizes the need for institutions that benefit from freely available software to get involved in its ongoing development, that an investment of resources is always required. Anyone who has worked with information technology in libraries, museums and archives knows that compared with the total cost of buying vendor software and making it actually do the desired job, there can be a great deal of room to save money while making a significant investment of resources in the process

DuraSpace's Solution Communities: Marshalling the Resources for Open-source Development

In his opening plenary address to the Open Repositories Conference, James Hilton made the statement that "open-source software is free like a puppy." This statement succinctly summarizes the need for institutions that benefit from freely available software to get involved in its ongoing development, that an investment of resources is always required. Anyone who has worked with information technology in libraries, museums and archives knows that compared with the total cost of buying vendor software and making it actually do the desired job, there can be a great deal of room to save money while making a significant investment of resources in the process

Project Hydra: Designing & Building a Reusable Framework for Multipurpose, Multifunction, Multi-institutional Repository-Powered Solutions

4th International Conference on Open RepositoriesThis presentation was part of the session : Fedora User Group PresentationsDate: 2009-05-20 03:30 PM – 05:00 PMThere is a clear business need in higher education for a flexible, reusable application framework that can support the rapid development of multiple systems tailored to distinct needs, but powered by a common underlying repository. Recognizing this common need, Stanford University, the University of Hull and the University of Virginia are collaborating on "Project Hydra", a three-year effort to create an application and middleware framework that, in combination with an underlying Fedora repository, will create a reusable environment for running multifunction, multipurpose repository-powered solutions. This paper details the collaborators' functional and technical design for such a framework, and will demonstrate the progress made to date on the initiative.JIS

Sisyphean Task or the Holy Grail? Satisfying Demands of Higher Education through Community-Driven Open Source Projects

What elements are essential to successful community-driven open source projects? How much governance and overhead is required to develop and sustain an open source project? What are the factors that enhance or limit the pace of development, the growth in the development community, community adoption and longevity? Many open source projects don't start out worrying about sustainability or longevity, but successful projects often require considerable effort to succeed over time. This presentation and panel discussion will explore the use of community-driven open source projects to achieve the needs in higher education and review some of the many factors that may influence viability for community-driven open source projects. Specific projects will be discussed, along with a description of incubation strategies, governance approaches, growth challenges, ongoing support models, sustaining vibrant developer communities and lessons learned

Hydra: A Technical and Community Framework For Customized, Reusable, Repository Solutions

While repositories provide obvious benefits in hosting and managing content, it is equally clear that there is no "one size fits all" solution to the range of digital asset management needs at a typical institution, much less across institutions. A system that supports the submission, approval and dissemination of electronic theses and dissertations, for example, has demonstrably different requirements than a digitization workflow solution, an e-science data repository, or media preservation and access system. There is a clear need in the repository community to readily develop and deploy content-, domain-, and institution-specific solutions that integrate the flexibility and richness of customized applications and workflows with the underlying power of repositories for content management, access and preservation. Hydra is a multi-institutional, multi-functional, multi-purpose framework that addresses this need on twin fronts. As a technical framework, it provides a toolkit of reusable components that can be combined and configured in different arrays to meet a diversity of content management needs. As a community framework, Hydra provides like-minded institutions with the mechanism to combine their individual development efforts, resources and priorities into a collective solution with breadth and depth that exceeds the capacity of any single institution to create, maintain or enhance on its own

Hydra: A Technical and Community Framework For Customized, Reusable, Repository Solutions

While repositories provide obvious benefits in hosting and managing content, it is equally clear that there is no "one size fits all" solution to the range of digital asset management needs at a typical institution, much less across institutions. A system that supports the submission, approval and dissemination of electronic theses and dissertations, for example, has demonstrably different requirements than a digitization workflow solution, an e-science data repository, or media preservation and access system. There is a clear need in the repository community to readily develop and deploy content-, domain-, and institution-specific solutions that integrate the flexibility and richness of customized applications and workflows with the underlying power of repositories for content management, access and preservation. Hydra is a multi-institutional, multi-functional, multi-purpose framework that addresses this need on twin fronts. As a technical framework, it provides a toolkit of reusable components that can be combined and configured in different arrays to meet a diversity of content management needs. As a community framework, Hydra provides like-minded institutions with the mechanism to combine their individual development efforts, resources and priorities into a collective solution with breadth and depth that exceeds the capacity of any single institution to create, maintain or enhance on its own

Genetic and seasonal determinants of vitamin D status in Confederated Salish and Kootenai Tribes (CSKT) participants

Background: Vitamin D is a hormone produced in the skin upon ultraviolet B (UVB) radiation. Vitamin D is a crucial regulator of calcium and phosphate levels for bone mineralization and other physiological roles. Vitamin D levels vary globally in human populations due to genetics, geography, and other demographic factors. It is estimated that 20-85 % of the variability in vitamin D levels is driven by genetic variation. To improve our understanding of contributors to vitamin D levels, we conducted a candidate-gene study in partnership with the Confederated Salish and Kootenai Tribes (CSKT). Methods: We recruited 472 CSKT study participants on the Flathead Reservation in Montana. Demographic factors included age, BMI, and gender (185 male and 287 female; ≥ 18 years old). Genomic DNA and plasma were isolated from whole blood. We sequenced 14 vitamin D regulatory candidate genes: CASR, CUBN, CYP2R1, CYP3A4,CYP24A1, CYP27B1, DHCR7, GC, RXRA, RXRB, RXRG, SULT2A1, UGT1A4, and VDR. We also measured plasma levels of vitamin D and vitamin D metabolites by liquid chromatography/mass-spectrometry (LC/MS), including the clinical marker of vitamin D status, 25-hydroxyvitamin D3 [25(OH)D3]. We tested demographic factors as well as common and rare genetic variants for statistical associations with vitamin D levels using bioinformatics software and R statistical programming language code. Results: We identified 7,370 total genetic variants with 8% (n = 585) of them being novel. We identified 60 genetic variants that may be of clinical significance (disease associated or predicted to influence medication response). Vitamin D levels were below sufficiency [25(OH)D3 + 25(OH)D2 levels \u3c 20 ng/mL] in 56 % of CSKT participants across the year. We observed seasonal vitamin D and metabolite level fluctuations in a seasonal, sinusoidal statistical model with peak concentrations in June – August and trough concentrations in December – February. In linear regression analysis, we found that age, BMI, season, and 5 variants in CUBN and CYP3A4 were significantly associated with 25(OH)D3 concentration (p-value\u3c 0.05). In logistic regression, we found that 4 variants in CUBN, CYP3A4, and UGT1A4 were associated with 25(OH)D sufficiency status [25(OH)D3 + 25(OH)D2 levels of 20 ng/mL] (p-value\u3c 0.05). Multivariate linear regression analysis revealed that genetic variation alone explained ~13% of the variability in 25(OH)D3 concentration in CSKT participants. Genetic variation and environmental factors together explained ~23 % of the variability in 25(OH)D3 concentration in CSKT participants. It is likely that genetic variation in additional genes and other environmental factors (e.g., dietary vitamin D intake) that were not included in this study explain the remaining variability in 25(OH)D3 concentration. Conclusion: This research addresses the need for increased inclusion of American Indian and Alaska Natives in precision medicine health research. We are the first to describe the contribution of season and genetics to vitamin D levels in an American Indian population. Our next steps will be to use these findings to perform mechanistic studies and develop interventional strategies for the CSKT people