364 research outputs found
Motion cue effects on pilot tracking
The results of two successive experimental investigations of the effects of motion cues on manual control tracking tasks are reported. The first of these was an IFR single-axis VTOL roll attitude control task. Describing function data show the dominant motion feedback quantity to be angular velocity. The second experimental task was multiaxis, that of precision hovering of a VTOL using separated instrument displays with reduced motion amplitude scaling. Performance data and pilot opinion show angular position to be the dominant cue when simulator linear motion is absent
Wetlands Mitigation: Retroactive Application of Clean Water Act Requirements to Property Destroyed by Natural Disasters
Complementary transcriptomic, lipidomic, and targeted functional genetic analyses in cultured Drosophila cells highlight the role of glycerophospholipid metabolism in Flock House virus RNA replication
Abstract Background Cellular membranes are crucial host components utilized by positive-strand RNA viruses for replication of their genomes. Published studies have suggested that the synthesis and distribution of membrane lipids are particularly important for the assembly and function of positive-strand RNA virus replication complexes. However, the impact of specific lipid metabolism pathways in this process have not been well defined, nor have potential changes in lipid expression associated with positive-strand RNA virus replication been examined in detail. Results In this study we used parallel and complementary global and targeted approaches to examine the impact of lipid metabolism on the replication of the well-studied model alphanodavirus Flock House virus (FHV). We found that FHV RNA replication in cultured Drosophila S2 cells stimulated the transcriptional upregulation of several lipid metabolism genes, and was also associated with increased phosphatidylcholine accumulation with preferential increases in lipid molecules with longer and unsaturated acyl chains. Furthermore, targeted RNA interference-mediated downregulation of candidate glycerophospholipid metabolism genes revealed a functional role of several genes in virus replication. In particular, we found that downregulation of Cct1 or Cct2, which encode essential enzymes for phosphatidylcholine biosynthesis, suppressed FHV RNA replication. Conclusion These results indicate that glycerophospholipid metabolism, and in particular phosphatidylcholine biosynthesis, plays an important role in FHV RNA replication. Furthermore, they provide a framework in which to further explore the impact of specific steps in lipid metabolism on FHV replication, and potentially identify novel cellular targets for the development of drugs to inhibit positive-strand RNA viruses.http://deepblue.lib.umich.edu/bitstream/2027.42/78268/1/1471-2164-11-183.xmlhttp://deepblue.lib.umich.edu/bitstream/2027.42/78268/2/1471-2164-11-183-S3.XLShttp://deepblue.lib.umich.edu/bitstream/2027.42/78268/3/1471-2164-11-183-S2.XLShttp://deepblue.lib.umich.edu/bitstream/2027.42/78268/4/1471-2164-11-183.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/78268/5/1471-2164-11-183-S4.XLShttp://deepblue.lib.umich.edu/bitstream/2027.42/78268/6/1471-2164-11-183-S1.XLSPeer Reviewe
Digital and social media: the panacea of transformative engagement with young people; rhetoric or reality? Qualitative based research exploring police led digital and social media engagement with young people in Nottinghamshire
The disengagement of young people from community participation is a debate that pervades the literature and is a concern for UK policing whose strategic aim is to secure the efficient and effective engagement of young people in an operational landscape that is shaped by austerity. Digital and Social Media is seen as offering immense potential to deliver enhanced participation at a fraction of the cost of traditional engagement, but there is a distinct lack of empirical research associated with the police use of digital and social media to engage young people. The aim of this research is to allow young people to shape the way Nottinghamshire Police engage with them via digital and social media. To this end, a 40-point engagement framework based on the principles of ‘Quid Pro Quo’ reciprocal engagement is offered as the product of this youthful insight. The theoretical positioning of the research is within the Interpretivist paradigm and social control theory and procedural justice theory justify why engaging young people is so important to the survival of the British style of policing. A qualitative methodology frames the research design, which includes the use of the semi-structured interview and four focus groups involving young people. The thesis suggests that young people are not disinterested, lackadaisical or apathetic when it comes to police engagement, they are simply disconnected from the police engagement framework, which appears to have failed historically to understand how and why young people wish to participate in policing. Whilst participants felt that Nottinghamshire Police’s digital offer is suitable for young people, it is concluded that digital and social media is not the ‘Holy Grail’ or indeed the panacea for police engagement and therefore young people may not yet be ready to accept such technology and swap physical visibility and accessibility for their virtual counterparts
Alien Registration- Stapleford, Blanche E. (South Portland, Cumberland County)
https://digitalmaine.com/alien_docs/20488/thumbnail.jp
Alien Registration- Stapleford, Blanche E. (South Portland, Cumberland County)
https://digitalmaine.com/alien_docs/20488/thumbnail.jp
Years of teaching experience and descriptions of educational situations
This study examined the relationship between years of teaching experience and the type of descriptions given of educational situations. Participants were certified teachers with 1 to 27 years of teaching experience and preservice teachers with 0 years of teaching experience. A coding system was developed as an objective method for extracting participants\u27 descriptions of actions and consequences pertaining to student and teacher behavior. Results did not support the original hypothesis that a relationship would be found between years of teaching experience and the descriptions made. However, several other relationships among certain characteristics of the descriptions were found.;The typical description made by participants was found to (1) focus descriptions of causal relationships on student actions and consequences rather than on teacher actions and consequences and (2) involve more complete and detailed descriptions of student action than of teacher action
Alien Registration- Stapleford, William P. (South Portland, Cumberland County)
https://digitalmaine.com/alien_docs/20489/thumbnail.jp
Experiments and a model for pilot dynamics with visual and motion inputs
Multimodality pilot model for visual and motion feedbacks derived from simulator progra
Pilot describing function measurements in a multiloop task
Pilot describing function measurements in multiloop control system tracking tas
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