183 research outputs found
Romualdo Trifone: giurista, storico e legislatore
The essay traces a profile of Romualdo Trifone, underlining the plan style, the anti-dogmatic
approach, the attention to the sources and, in particular, to the custom. It is demonstrated in which
way, in Trofone's view, law is conceived as a social product, submitted to the influence of essential
space-time variables
Tamoxifen in treatment of hepatocellular carcinoma: a randomised controlled trial
Background Results from small randomised trials on tamoxifen in the treatment of hepatocellular carcinoma (HCC) are conflicting, We studied whether the addition of tamoxifen to best supportive care prolongs survival of patients with HCC.
Methods Patients with any stage of HCC were eligible, irrespective of locoregional treatment. Randomisation was centralised, with a minimisation procedure accounting for centre, evidence of disease, and time from diagnosis. Patients were randomly allocated best supportive care alone or in addition to tamoxifen, Tamoxifen was given orally, 40 mg per day, from randomisation until death.
Results 496 patients from 30 institutions were randomly allocated treatment from January, 1995, to January, 1997. Information was available for 477 patients. By Sept 15, 1997, 119 (50%) of 240 and 130 (55%) of 237 patients had died in the control and tamoxifen arms, respectively. Median survival was 16 months and 15 months (p=0.54), respectively, No differences were found within subgroups defined by prognostic variables. Relative hazard of death for patients receiving tamoxifen was 1.07 (95% CI 0.83-1.39).
Interpretation Our findings show that tamoxifen is not effective in prolonging survival of patients with HCC
La condotta del ginecologo e dell'ostetrico nel caleidoscopio della responsabilitĂ medica
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