5,122 research outputs found
Fully automated segmentation and tracking of the intima media thickness in ultrasound video sequences of the common carotid artery
AbstractâThe robust identification and measurement of the intima media thickness (IMT) has a high clinical relevance because it represents one of the most precise predictors used in the assessment of potential future cardiovascular events. To facilitate the analysis of arterial wall thickening in serial clinical investigations, in this paper we have developed a novel fully automatic algorithm for the segmentation, measurement, and tracking of the intima media complex (IMC) in B-mode ultrasound video sequences. The proposed algorithm entails a two-stage image analysis process that initially addresses the segmentation of the IMC in the first frame of the ultrasound video sequence using a model-based approach; in the second step, a novel customized tracking procedure is applied to robustly detect the IMC in the subsequent frames. For the video tracking procedure, we introduce a spatially coherent algorithm called adaptive normalized correlation that prevents the tracking process from converging to wrong arterial interfaces. This represents the main contribution of this paper and was developed to deal with inconsistencies in the appearance of the IMC over the cardiac cycle. The quantitative evaluation has been carried out on 40 ultrasound video sequences of the common carotid artery (CCA) by comparing the results returned by the developed algorithm with respect to ground truth data that has been manually annotated by clinical experts. The measured IMTmean ± standard deviation recorded by the proposed algorithm is 0.60 mm ± 0.10, with a mean coefficient of variation (CV) of 2.05%, whereas the corresponding result obtained for the manually annotated ground truth data is 0.60 mm ± 0.11 with a mean CV equal to 5.60%. The numerical results reported in this paper indicate that the proposed algorithm is able to correctly segment and track the IMC in ultrasound CCA video sequences, and we were encouraged by the stability of our technique when applied to data captured under different imaging conditions. Future clinical studies will focus on the evaluation of patients that are affected by advanced cardiovascular conditions such as focal thickening and arterial plaques
Behavioural compensation by drivers of a simulator when using a vision enhancement system
Technological progress is suggesting dramatic changes to the tasks of the driver, with the general aim of making driving environment safer. Before any of these technologies are implemented, empirical research is required to establish if these devices do, in fact, bring about the anticipated improvements. Initially, at least, simulated driving environments offer a means of conducting this research. The study reported here concentrates on the application of a vision enhancement (VE) system within the risk homeostasis paradigm. It was anticipated, in line with risk homeostasis theory, that drivers would compensate for the reduction in risk by increasing speed. The results support the hypothesis although, after a simulated failure of the VE system, drivers did reduce their speed due to reduced confidence in the reliability of the system
Vibrational Satellites of CS, CS, and CS: Microwave Spectral Taxonomy as a Stepping Stone to the Millimeter-Wave Band
We present a microwave spectral taxonomy study of several hydrocarbon/CS
discharge mixtures in which more than 60 distinct chemical species, their more
abundant isotopic species, and/or their vibrationally excited states were
detected using chirped-pulse and cavity Fourier-transform microwave
spectroscopies. Taken together, in excess of 85 unique variants were detected,
including several new isotopic species and more than 25 new vibrationally
excited states of CS, CS, and CS, which have been assigned on the
basis of published vibration-rotation interaction constants for CS, or
newly calculated ones for CS and CS. On the basis of these precise,
low-frequency measurements, several vibrationally exited states of CS and
CS were subsequently identified in archival millimeter-wave data in the
253--280 GHz frequency range, ultimately providing highly accurate catalogs for
astronomical searches. As part of this work, formation pathways of the two
smaller carbon-sulfur chains were investigated using C isotopic
spectroscopy, as was their vibrational excitation. The present study
illustrates the utility of microwave spectral taxonomy as a tool for complex
mixture analysis, and as a powerful and convenient `stepping stone' to higher
frequency measurements in the millimeter and submillimeter bands.Comment: Accepted in PCC
The Composition of Human Milk and Infant Faecal Microbiota Over the First Three Months of Life: A Pilot Study
peer-reviewedHuman milk contains a diverse array of bioactives and is also a source of bacteria for the developing infant gut. The aim of this study was to characterize the bacterial communities in human milk and infant faeces over the first 3 months of life, in 10 mother-infant pairs. The presence of viable Bifidobacterium and Lactobacillus in human milk was also evaluated. MiSeq sequencing revealed a large diversity of the human milk microbiota, identifying over 207 bacterial genera in milk samples. The phyla Proteobacteria and Firmicutes and the genera Pseudomonas, Staphylococcus and Streptococcus were the predominant bacterial groups. A core of 12 genera represented 81% of the microbiota relative abundance in milk samples at week 1, 3 and 6, decreasing to 73% at week 12. Genera shared between infant faeces and human milk samples accounted for 70â88% of the total relative abundance in infant faecal samples, supporting the hypothesis of vertical transfer of bacteria from milk to the infant gut. In addition, identical strains of Bifidobacterium breve and Lactobacillus plantarum were isolated from the milk and faeces of one mother-infant pair. Vertical transfer of bacteria via breastfeeding may contribute to the initial establishment of the microbiota in the developing infant intestine
Mediation, translation and local ecologies: understanding the impact of policy levers on FE colleges
This article reports the views of managers and tutors on the role of policy âleversâ on teaching, learning, and inclusion in colleges of Further Education (FE) in our research project, âThe impact of policy on learning and inclusion in the Learning and Skills Sector (LSS)â.i Using data from five research visits conducted over two years in eight FE learning sites, we explore the processes by which colleges âmediateâ and âtranslateâ national policy levers and how this affects their ability to respond to local need. The paper tentatively develops three related concepts/metaphors to explain the complexity of the policy/college interface â âthe process of mediationâ, âacts of translationâ and âlocal ecologiesâ. We found that policy levers interacted with a complex set of national, local and institutional factors as colleges responded to pressures from the external environment and turned these into internal plans, systems and practices. We conclude by suggesting that national policy-makers, who design national policy levers, may not be fully aware of these complexities and we make the case for the benefits of greater local control over policy levers, where these interactions are better understood
A New Approach toward Transition State Spectroscopy
Chirped-Pulse millimetre-Wave (CPmmW) rotational spectroscopy provides a new
class of information about photolysis transition state(s). Measured intensities
in rotational spectra determine species-isomer-vibrational populations,
provided that rotational populations can be thermalized. The formation and
detection of S0 vinylidene is discussed in the limits of low and high initial
rotational excitation. CPmmW spectra of 193 nm photolysis of Vinyl Cyanide
(Acrylonitrile) contain J=0-1 transitions in more than 20 vibrational levels of
HCN, HNC, but no transitions in vinylidene or highly excited local-bender
vibrational levels of acetylene. Reasons for the non-observation of the
vinylidene co-product of HCN are discussed.Comment: Accepted by Faraday Discussion
A field study of team working in a new human supervisory control system
This paper presents a case study of an investigation into team behaviour in an energy distribution company. The main aim was to investigate the impact of major changes in the company on system performance, comprising human and technical elements. A socio-technical systems approach was adopted. There were main differences between the teams investigated in the study: the time of year each control room was studied (i.e. summer or winter),the stage of development each team was in (i.e. 10 months), and the team structure (i.e. hierarchical or heterarchical). In all other respects the control rooms were the same: employing the same technology and within the same organization. The main findings were: the teams studied in the winter months were engaged in more `planningâ and `awarenessâ type of activities than those studies in the summer months. Newer teams seem to be engaged in more sharing of information than older teams, which maybe indicative of the development process. One of the hierarchical teams was engaged in more `system-drivenâ activities than the heterarchical team studied at the same time of year. Finally, in general, the heterarchical team perceived a greater degree of team working culture than its hierarchical counterparts. This applied research project confirms findings from laboratory research and emphasizes the importance of involving ergonomics in the design of team working in human supervisory control
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