Online victimization, womanism, and body esteem among young Black women.: A structural equation modeling approach

Digital media use represents a central part of young adults’ daily life, within which social interactions increasingly center on visual content. While visual content, such as representations of self, may facilitate positive social interactivity, it may also increase susceptibility to harmful social interactions, such as appearance-related online victimization. Black women’s bodies are often the target of gendered racial microaggressions and sexual victimization which can contribute to body image concerns. Still, the online victimization–body esteem link among Black women remains unexamined. This study used structural equation modeling to examine the associations between four categories of online victimization (i.e., general online victimization, online individual racial victimization, online vicarious racial victimization, online sexual victimization) and body esteem. We further examined whether womanism, an identity-based factor, moderated the relationship between online victimization and body esteem. A sample of 1,595 young Black women completed an online survey. Results showed that online sexual victimization was significantly negatively associated with body esteem and that high levels of womanism buffered the harmful impact of general online victimization on body esteem. Future research is needed to examine Black women’s and gender expansive people’s experiences with online gendered racial victimization along with other forms of online intersectional oppressio

Black women’s experiences of gendered racial sexual objectification, body image, and depressive symptoms

Black women navigate unique sexual objectification experiences and concerns about their bodies as a consequence of the race- and gender-based marginalization that they face. However, less is known about the influence of gendered racial sexual objectification experiences on Black women’s mental health (i.e., depressive symptoms) or the contributions of key body image indicators (i.e., body surveillance and current-ideal body image discrepancy) that reflect Black women’s engagement in monitoring and managing their bodies. We surveyed 1595 Black women to test our hypotheses that experiences of gendered racial sexual objectification (i.e., frequency and stress appraisal) would be positively associated with depressive symptoms and that body surveillance and current-ideal body image discrepancy would moderate this association. Analyses showed that more frequent experiences of gendered racial sexual objectification and higher stress appraisal of these experiences were significantly associated with more depressive symptoms. Furthermore, body surveillance and current-ideal body image discrepancy moderated the relation between gendered racial sexual objectification and depressive symptoms. Findings highlight how Black women’s objectification and increased engagement in body monitoring and management practices are associated with their experiences of depressive symptoms, and thus, may negatively influence their mental health

Gendered racial microaggressions scale: Measurement invariance across sexual orientation

Gendered racial microaggressions are often assessed using the Gendered Racial Microaggressions Scale. Despite its use with mixed samples of heterosexual and sexual minority Black women, this instrument has yet to be evaluated for its measurement invariance across sexual orientation. This study evaluated the measurement invariance of the Gendered Racial Microaggressions Scale across sexual orientation (heterosexual [n=1,147] versus lesbian, gay, or bisexual [LGB], n=359) in a sample of 1,506 Black cisgender women ages 18–30 years old. The Gendered Racial Microaggressions Scale’s four-factor structure, including Beauty and Sexual Objectification, Silenced and Marginalized, Strong Black Woman, and Angry Black Woman, was replicated with our sample. Results from the multigroup confirmatory factor analysis indicated the Gendered Racial Microaggressions Scale had configural, metric, and scalar invariance across sexual orientation groups. Strict invariance was not established. Multi-group comparison of latent factor mean scores revealed Black LGB women as having higher Beauty and Sexual Objectification scores than Black heterosexual women on the Gendered Racial Microaggressions stress appraisal scale. The Gendered Racial Microaggressions Scale can be recommended in meaningfully assessing differences in latent factor mean scores among Black heterosexual and LGB women. Practitioners, researchers, and policy makers should seek to address the role of intersectional microaggressions in the lived experiences of sexual and gender minorities of color, including as it relates to systemic disadvantage and health, mental health, and social disparitie

A less-traveled path for data in bioprocess development: From dynamic experiments to dynamic process models

Please click Additional Files below to see the full abstract

The Shapiro Design Lab Residency

A publication documenting the inaugural year of the Shapiro Design Lab Residency.https://deepblue.lib.umich.edu/bitstream/2027.42/142813/1/DesignLabResidency_Publication.pdfDescription of DesignLabResidency_Publication.pdf : PDF of publicatio

Variable levels of drift in tunicate cardiopharyngeal gene regulatory elements.

Background: Mutations in gene regulatory networks often lead to genetic divergence without impacting gene expression or developmental patterning. The rules governing this process of developmental systems drift, including the variable impact of selective constraints on different nodes in a gene regulatory network, remain poorly delineated. Results: Here we examine developmental systems drift within the cardiopharyngeal gene regulatory networks of two tunicate species, Corella inflata and Ciona robusta. Cross-species analysis of regulatory elements suggests that trans-regulatory architecture is largely conserved between these highly divergent species. In contrast, cis-regulatory elements within this network exhibit distinct levels of conservation. In particular, while most of the regulatory elements we analyzed showed extensive rearrangements of functional binding sites, the enhancer for the cardiopharyngeal transcription factor FoxF is remarkably well-conserved. Even minor alterations in spacing between binding sites lead to loss of FoxF enhancer function, suggesting that bound trans-factors form position-dependent complexes. Conclusions: Our findings reveal heterogeneous levels of divergence across cardiopharyngeal cis-regulatory elements. These distinct levels of divergence presumably reflect constraints that are not clearly associated with gene function or position within the regulatory network. Thus, levels of cis-regulatory divergence or drift appear to be governed by distinct structural constraints that will be difficult to predict based on network architectur

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts