235 research outputs found
Effects of Composite Restorations on the Periodontal Membrane in Monkeys
We evaluated the histopathological response of the periodontal membrane to intentionolly-replanted teeth carrying composite (experimental) and silver amalgam (control) restorations in the middle third of each root. The study revealed that the amalgam produced, in the periodontal tissues, an initial localized inflammation that subsided with the subsequent formation of a fibrous capsule. However, the periodontal membrane adjacent to the composite resin restorations demonstrated chronic inflammation. It was concluded that the composite evoked chronic inflammatory responses of the periodontal tissues in monkeys.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67994/2/10.1177_00220345830620011801.pd
HPV-18 transformed cells fail to arrest in G1 in response to quercetin treatment
Previous work with primary human keratinocytes demonstrated that quercetin, a potent mutagen found in high levels in bracken fern (Pteridium aquilinum), arrested cells in G1 with concomitant elevation of the cyclin-dependent kinase inhibitor (cdki) p27Kip1. Expression of the human papillomavirus type 16 (HPV-16) E6 and E7 oncoproteins, under transcriptional control of a heterologous promoter, in transformed keratinocytes failed to abrogate this arrest [Beniston, R., Campo, M.S., 2003. Quercetin elevates p27(Kip1) and arrests both primary and HPV-16 E6/E7 transformed human keratinocytes in G1. Oncogene 22, 5504–5514]. Given the link between papillomavirus infection, bracken fern in the diet and cancer of the oesophagus in humans, we wished to investigate further whether cells transformed by the whole genome of HPV-16 or HPV-18, with E6 and E7 under the transcriptional control of their respective homologous promoters, would be similarly arrested in G1 by quercetin. In agreement with earlier work, quercetin arrested HPV-16 transformed cells in G1 with an increase in the cyclin-dependent kinase inhibitor p27Kip1. However, HPV-18 transformed cells did not arrest after quercetin treatment. The failure of HPV-18 transformed cells to arrest in G1 was linked to the up-regulation of the HPV-18 long control region (LCR) by quercetin, maintaining high expression of the viral transforming proteins. Transcriptional up-regulation of the HPV-18 LCR was mediated by a “quercetin responsive element” homologous to the one identified previously in the bovine papillomavirus type 4 (BPV-4) LCR
Continuum theory of vacancy-mediated diffusion
We present and solve a continuum theory of vacancy-mediated diffusion (as
evidenced, for example, in the vacancy driven motion of tracers in crystals).
Results are obtained for all spatial dimensions, and reveal the strongly
non-gaussian nature of the tracer fluctuations. In integer dimensions, our
results are in complete agreement with those from previous exact lattice
calculations. We also extend our model to describe the vacancy-driven
fluctuations of a slaved flux line.Comment: 25 Latex pages, subm. to Physical Review
Strong-coupling expansions for chiral models of electroweak symmetry breaking
We consider chiral models with fermions in the limit of
infinitely large local bare Yukawa coupling. When the scalar field is subject
to non-linear constraint, phase transitions in these models are seen to be
identical to those in the corresponding purely bosonic ones. Relaxing the
non-linear constraint, we compute the seventh-order strong-coupling series for
the susceptibility in these models and analyze them numerically for the
case. We find that in four dimensions the approach to the
phase transition follows to a good accuracy the mean-field critical behavior,
indicating the absence of non-trivial fixed points at strong coupling and being
consistent with the first-order nature of the transition. In three dimensions,
the strongly-coupled bosonic model (without gauge fields) has
a first-order transition strong enough to accommodate electroweak baryogenesis
only for a narrow region of the bare parameter space.Comment: 11 pages, latex, no figure
Transfer Matrices and Partition-Function Zeros for Antiferromagnetic Potts Models. V. Further Results for the Square-Lattice Chromatic Polynomial
We derive some new structural results for the transfer matrix of
square-lattice Potts models with free and cylindrical boundary conditions. In
particular, we obtain explicit closed-form expressions for the dominant (at
large |q|) diagonal entry in the transfer matrix, for arbitrary widths m, as
the solution of a special one-dimensional polymer model. We also obtain the
large-q expansion of the bulk and surface (resp. corner) free energies for the
zero-temperature antiferromagnet (= chromatic polynomial) through order q^{-47}
(resp. q^{-46}). Finally, we compute chromatic roots for strips of widths 9 <=
m <= 12 with free boundary conditions and locate roughly the limiting curves.Comment: 111 pages (LaTeX2e). Includes tex file, three sty files, and 19
Postscript figures. Also included are Mathematica files data_CYL.m and
data_FREE.m. Many changes from version 1: new material on series expansions
and their analysis, and several proofs of previously conjectured results.
Final version to be published in J. Stat. Phy
Transfer matrices and partition-function zeros for antiferromagnetic Potts models. VI. Square lattice with special boundary conditions
We study, using transfer-matrix methods, the partition-function zeros of the
square-lattice q-state Potts antiferromagnet at zero temperature (=
square-lattice chromatic polynomial) for the special boundary conditions that
are obtained from an m x n grid with free boundary conditions by adjoining one
new vertex adjacent to all the sites in the leftmost column and a second new
vertex adjacent to all the sites in the rightmost column. We provide numerical
evidence that the partition-function zeros are becoming dense everywhere in the
complex q-plane outside the limiting curve B_\infty(sq) for this model with
ordinary (e.g. free or cylindrical) boundary conditions. Despite this, the
infinite-volume free energy is perfectly analytic in this region.Comment: 114 pages (LaTeX2e). Includes tex file, three sty files, and 23
Postscript figures. Also included are Mathematica files data_Eq.m,
data_Neq.m,and data_Diff.m. Many changes from version 1, including several
proofs of previously conjectured results. Final version to be published in J.
Stat. Phy
Light-Front Holography, Light-Front Wavefunctions, and Novel QCD Phenomena
Light-Front Holography, a remarkable feature of the AdS/CFT correspondence,
maps amplitudes in anti-de Sitter (AdS) space to frame-independent light-front
wavefunctions of hadrons in physical space-time. The model leads to an
effective confining light-front QCD Hamiltonian and a single-variable
light-front Schrodinger equation which determines the eigenspectrum and the
light-front wavefunctions of hadrons for general spin and orbital angular
momentum. The coordinate z in AdS space is identified with a Lorentz-invariant
coordinate zeta which measures the separation of the constituents within a
hadron at equal light-front time and determines the off-shell dynamics of the
bound-state wavefunctions and the fall-off in the invariant mass of the
constituents. The soft-wall holographic model, modified by a positive-sign
dilaton metric, leads to a remarkable one-parameter description of
nonperturbative hadron dynamics -- a semi-classical frame-independent first
approximation to the spectra and light-front wavefunctions of meson and
baryons. The model predicts a Regge spectrum of linear trajectories with the
same slope in the leading orbital angular momentum L of hadrons and the radial
quantum number n. The hadron eigensolutions projected on the free Fock basis
provides the complete set of valence and non-valence light-front Fock state
wavefunctions which describe the hadron's momentum and spin distributions
needed to compute measures of hadron structure at the quark and gluon level.
The effective confining potential also creates quark- antiquark pairs. The
AdS/QCD model can be systematically improved by using its complete orthonormal
solutions to diagonalize the full QCD light-front Hamiltonian or by applying
the Lippmann-Schwinger method to systematically include the QCD interaction
terms. A new perspective on quark and gluon condensates is also presented.Comment: Presented at LIGHTCONE 2011, 23 - 27 May, 2011, Dallas, T
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