5 research outputs found
Serous borderline tumor of the fallopian tube presented as hematosalpinx: a case report
BACKGROUND: Compared with their ovarian counterparts, serous borderline tumors of the fallopian tube are uncommon, with limited experience about their clinical behaviour. We present a case of serous borderline tumor of the fallopian tube with unusual presentation and summarise all the published cases to date. CASE PRESENTATION: A case of serous borderline tumor of the fallopian tube in a 34-year old patient is presented, incidentally found during routine gynecologic examination. At laparoscopy the tumor was unusualy presented as hematosalpinx and was treated by salpingectomy. Cell-cycle analysis of the tumor tissue revealed a diploid DNA content and a low S-phase fraction. There was no evidence of the disease during the follow-up period of 4.6 years. CONCLUSION: The current case and review of the literature suggest salpingectomy as the optimal treatment for patients with serous borderline tumor of the fallopian tube
Optimization of fast three-electrode spark gaps isolated with a SF6 and he mix ture
This paper considered the possibility of reducing the dissipation of the trigger time of the three-electrode spark gaps with a separated triggered electrode. The work is of a theoretical, numerical and of experimental nature. The experiments were performed on a spark gap model under well-controlled laboratory conditions. It was determined that the results obtained with the model can be applied to the spark gap prototype. Unlike the previous research in this area, the computer-designed spark gap that was used can be triggered with one mechanism only. Also, as opposed to the previous study, a mixture of SF6 and He gases and the third electrode with a double ionization effect were used. The obtained results showed the optimal combination of the construction solution, insulation gas, triggered impulse, and the triggered electrode's shape, reduce the stochastic dissipation of a random variable far in the sub-microsecond field. This result is of great significance for the parallel triggering of current and voltage generators to obtain the best superposition signals
Chemo-protective and regenerative effects of diarylheptanoids from the bark of black alder (Alnus glutinosa) in human normal keratinocytes
Medicinal plants are recognized from ancient times as a source of diverse therapeutic agents and many of them are used as dietary supplements. Comprehensive approaches are needed that would identify bioactive components with evident activity against specific indications and provide a better link between science (ethno-botany, chemistry, biology and pharmacology) and market Recently, the bark of black alder (Alnus glutinosa) appeared at market in the form of food supplement for treatment of different skin conditions. This study aimed to evaluate protective effects of two diarylheptanoids isolated from the bark of black alder: platyphylloside, 5(S)-1,7-di(4-hydroxyphenyl)-3-heptanone-5-O-beta-D-glucopyranoside (1) and its newly discovered analog 5(S)-1,7-di(4-hydroxyphenyl)-5-O-beta-D-[6-(E-p-coumaroylglucopyranosyl)]heptane-3-one (2) towards doxorubicin damaging activity. To that end, we employed HaCaT cells, non-cancerous human keratinocytes commonly used for skin regenerative studies. Diarylheptanoids significantly antagonized the effects of doxorubicin by lowering the sensitivity of HaCaT cells to this drug. Compound 2 prevented doxorubicin-induced cell death by activating autophagy. Both land 2 protected HaCaT cells against doxorubicin-induced DNA damage. They significantly promoted migration and affected F-actin distribution. These results indicate that chemo-protective effects of diarylheptanoids may occur at multiple subcellular levels. Therefore, diarylheptanoids 1 and 2 could be considered as protective agents for non-cancerous dividing cells during chemotherapy.Accepted version: [http://cer.ihtm.bg.ac.rs/handle/123456789/3185
Serous borderline tumor of the fallopian tube presented as hematosalpinx: a case report-0
<p><b>Copyright information:</b></p><p>Taken from "Serous borderline tumor of the fallopian tube presented as hematosalpinx: a case report"</p><p>BMC Cancer 2005;5():129-129.</p><p>Published online 7 Oct 2005</p><p>PMCID:PMC1282573.</p><p>Copyright Ā© 2005 Krasevic et al; licensee BioMed Central Ltd.</p>re is no invasion into the wall of the tube (top). Stratification and budding of the epithelium with focal nuclear atypia (high magnification)
Association of gene variants in TLR4 and IL-6 genes with Perthes disease
Uvod Pertesova bolest je idiopatska avaskularna osteonekroza proksimalne epifize femura koja se javlja kod dece. Etiologija ove bolesti je nepoznata. Tokom razvoja Pertesove bolesti zastupljen je proces zapaljenja, za koji je pokazano da utiÄe na remodelovanje koÅ”tanog tkiva. Cilj rada S obzirom na to da genetiÄki faktori koji utiÄu na proces zapaljenja dosad nisu ispitivani kod Pertesove bolesti, cilj ovog istraživanja je bio da se utvrdi povezanost uÄestalosti varijanti u genima koji uÄestvuju u inflamatornom odgovoru, TLR4 (engl. toll-like receptor 4) i IL-6 (interleukin 6), i ove bolesti. Metode rada Ispitano je 37 dece s Pertesovom boleÅ”Äu i 50 zdravih osoba. Metodom PCR-RFLP odreÄeni su polimorfizmi medijatora zapaljenja TLR4 (Asp299Gly, Thr399Ile) i IL-6 (G-174C, G-597A). Rezultati Pokazano je da su polimorfizmi IL-6 G-174C i G-597A u naÅ”em ispitivanju bili u potpunoj gametskoj neravnoteži vezanosti. U kontrolnoj grupi je bilo statistiÄki znaÄajno viÅ”e nosilaca heterozigotnog genotipa IL-6 G-174C/G-597A u poreÄenju sa grupom ispitanika s Pertesovom boleÅ”Äu (p=0,047; OR=2,49; 95% CI=1,00-6,21). TakoÄe, grupa bolesnika nije bila u Hardi- Vajnbergovoj ravnoteži za polimorfizme IL-6 G-174C/G-597A. Nije primeÄena statistiÄki znaÄajna razlika u raspodeli genotipova za polimorfizme analizirane u TLR4 genu. Raspodela genotipova meÄu grupama bolesnika formiranih na osnovu uzrasta kada se bolest pojavila nije pokazala statistiÄki znaÄajnu povezanost s analiziranim polimorfizmima. ZakljuÄak NaÅ”e istraživanje je pokazalo da su nosioci heterozigotnog genotipa za IL-6 G-174C/G-597A polimorfizme bili znaÄajno ÄeÅ”Äi u kontrolnoj grupi nego u grupi dece obolele od Pertesove bolesti. Na osnovu toga zakljuÄili smo da je kod dece koja su nosioci heterozigotnog genotipa za ove polimorfizme manja verovatnoÄa za razvoj Pertesove bolesti nego kod nosilaca oba homozigotna genotipa.Introduction Perthes disease is idiopathic avascular osteonecrosis of the hip in children, with unknown etiology. Inflammation is present during development of Perthes disease and it is known that this process influences bone remodeling. Objective Since genetic studies related to inflammation have not been performed in Perthes disease so far, the aim of this study was to analyze the association of frequencies of genetic variants of immune response genes, toll-like receptor 4 (TLR4) and interleukin-6 (IL-6), with this disease. Methods The study cohort consisted of 37 patients with Perthes disease and 50 healthy controls. Polymorphisms of well described inflammatory mediators: TLR4 (Asp299Gly, Thr399Ile) and IL-6 (G-174C, G- 597A) were determined by polymerase chain reaction restriction fragment length polymorphism method. Results IL-6 G-174C and G-597A polymorphisms were in complete linkage disequilibrium. A statistically significant increase of heterozygote subjects for IL-6 G-174C/G-597A was found in controls in comparison to Perthes patient group (p=0.047, OR=2.49, 95% CI=1.00-6.21). Also, the patient group for IL-6 G-174C/G- 597A polymorphisms was not in Hardy-Weinberg equilibrium. No statistically significant differences were found between patient and control groups for TLR4 analyzed polymorphisms. A stratified analysis by the age at disease onset also did not reveal any significant difference for all analyzed polymorphisms. Conclusion Our study revealed that heterozygote subjects for the IL-6 G-174C/G-597A polymorphisms were significantly overrepresented in the control group than in the Perthes patient group. Consequently, we concluded that children who are heterozygous for these polymorphisms have a lower chance of developing Perthes disease than carriers of both homozygote genotypes